Refine
Year of publication
Document Type
- Article (1527)
- Part of a Book (594)
- Conference Proceeding (482)
- Book (397)
- Moving Images (173)
- Other (164)
- Bachelor Thesis (65)
- Report (42)
- Working Paper (39)
- Part of Periodical (38)
Language
- German (2828)
- English (756)
- Portuguese (7)
- Multiple languages (2)
- Spanish (2)
- French (1)
- Dutch (1)
- Russian (1)
Keywords
- Nachhaltigkeit (23)
- Kommunikation (9)
- Digitalisierung (8)
- Sustainability (8)
- Landschaftsarchitektur (7)
- Logistik (7)
- Building Information Modeling (6)
- Physiotherapie (6)
- Solarthermie (6)
- physiotherapy (6)
Institute
- Fakultät WiSo (2149)
- Fakultät AuL (717)
- Institut für Kommunikationsmanagement (198)
- Institut für Management und Technik (156)
- Institut für Duale Studiengänge (150)
- Fakultät IuI (93)
- Institut für Theaterpädagogik (50)
- Fakultät MKT (39)
- Präsidium Hochschule Osnabrück (27)
- Institut für Musik (9)
Background
In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammation. Epigenetic modifications of the chromatin confer plasticity to the genetic information and give insight into how tissues use the genetic information to adapt to environmental factors. The oral mucosa is particularly exposed to environmental stressors such as a variable microbiota. Likewise, persistent oral inflammation is the most important intrinsic risk factor for the oral inflammatory disease periodontitis and has strong potential to alter DNA-methylation patterns. The aim of the current study was to identify epigenetic changes of the oral masticatory mucosa in response to long-term inflammation that resulted in periodontitis.
Methods and results
Genome-wide CpG methylation of both inflamed and clinically uninflamed solid gingival tissue biopsies of 60 periodontitis cases was analyzed using the Infinium MethylationEPIC BeadChip. We validated and performed cell-type deconvolution for infiltrated immune cells using the EpiDish algorithm. Effect sizes of DMPs in gingival epithelial and fibroblast cells were estimated and adjusted for confounding factors using our recently developed “intercept-method”. In the current EWAS, we identified various genes that showed significantly different methylation between periodontitis-inflamed and uninflamed oral mucosa in periodontitis patients. The strongest differences were observed for genes with roles in wound healing (ROBO2, PTP4A3), cell adhesion (LPXN) and innate immune response (CCL26, DNAJC1, BPI). Enrichment analyses implied a role of epigenetic changes for vesicle trafficking gene sets.
Conclusions
Our results imply specific adaptations of the oral mucosa to a persistent inflammatory environment that involve wound repair, barrier integrity, and innate immune defense.
Background
In DNA methylation analyses like epigenome-wide association studies, effects in differentially methylated CpG sites are assessed. Two kinds of outcomes can be used for statistical analysis: Beta-values and M-values. M-values follow a normal distribution and help to detect differentially methylated CpG sites. As biological effect measures, differences of M-values are more or less meaningless. Beta-values are of more interest since they can be interpreted directly as differences in percentage of DNA methylation at a given CpG site, but they have poor statistical properties. Different frameworks are proposed for reporting estimands in DNA methylation analysis, relying on Beta-values, M-values, or both.
Results
We present and discuss four possible approaches of achieving estimands in DNA methylation analysis. In addition, we present the usage of M-values or Beta-values in the context of bioinformatical pipelines, which often demand a predefined outcome. We show the dependencies between the differences in M-values to differences in Beta-values in two data simulations: a analysis with and without confounder effect. Without present confounder effects, M-values can be used for the statistical analysis and Beta-values statistics for the reporting. If confounder effects exist, we demonstrate the deviations and correct the effects by the intercept method. Finally, we demonstrate the theoretical problem on two large human genome-wide DNA methylation datasets to verify the results.
Conclusions
The usage of M-values in the analysis of DNA methylation data will produce effect estimates, which cannot be biologically interpreted. The parallel usage of Beta-value statistics ignores possible confounder effects and can therefore not be recommended. Hence, if the differences in Beta-values are the focus of the study, the intercept method is recommendable. Hyper- or hypomethylated CpG sites must then be carefully evaluated. If an exploratory analysis of possible CpG sites is the aim of the study, M-values can be used for inference.
Background
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are frequent and serious complications after surgery. We aim to investigate the association between genetic variants in cholinergic candidate genes according to the Kyoto encyclopedia of genes and genomes - pathway: cholinergic neurotransmission with the development of POD or POCD in elderly patients.
Methods
This analysis is part of the European BioCog project (www.biocog.eu), a prospective multicenter observational study with elderly surgical patients. Patients with a Mini-Mental-State-Examination score ≤ 23 points were excluded. POD was assessed up to seven days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method and a patient chart review. POCD was assessed three months after surgery with a neuropsychological test battery. Genotyping was performed on the Illumina Infinium Global Screening Array. Associations with POD and POCD were analyzed using logistic regression analysis, adjusted for age, comorbidities and duration of anesthesia (for POCD analysis additionally for education). Odds ratios (OR) refer to minor allele counts (0, 1, 2).
Results
745 patients could be included in the POD analysis, and 452 in the POCD analysis. The rate of POD within this group was 20.8% (155 patients), and the rate of POCD was 10.2% (46 patients). In a candidate gene approach three genetic variants of the cholinergic genes CHRM2 and CHRM4 were associated with POD (OR [95% confidence interval], rs8191992: 0.61[0.46; 0.80]; rs8191992: 1.60[1.22; 2.09]; rs2067482: 1.64[1.10; 2.44]). No associations were found for POCD.
Conclusions
We found an association between genetic variants of CHRM2 and CHRM4 and POD. Further studies are needed to investigate whether disturbances in acetylcholine release and synaptic plasticity are involved in the development of POD.
A comparison study on modeling of clustered and overdispersed count data for multiple comparisons
(2021)
Data collected in various scientific fields are count data. One way to analyze such data is to compare the individual levels of the factor treatment using multiple comparisons. However, the measured individuals are often clustered – e.g. according to litter or rearing. This must be considered when estimating the parameters by a repeated measurement model. In addition, ignoring the overdispersion to which count data is prone leads to an increase of the type one error rate. We carry out simulation studies using several different data settings and compare different multiple contrast tests with parameter estimates from generalized estimation equations and generalized linear mixed models in order to observe coverage and rejection probabilities. We generate overdispersed, clustered count data in small samples as can be observed in many biological settings. We have found that the generalized estimation equations outperform generalized linear mixed models if the variance-sandwich estimator is correctly specified. Furthermore, generalized linear mixed models show problems with the convergence rate under certain data settings, but there are model implementations with lower implications exists. Finally, we use an example of genetic data to demonstrate the application of the multiple contrast test and the problems of ignoring strong overdispersion.
BACKGROUND:
Intraoperative electroencephalography (EEG) signatures related to the development of postoperative delirium (POD) in older patients are frequently studied. However, a broad analysis of the EEG dynamics including preoperative, postinduction, intraoperative and postoperative scenarios and its correlation to POD development is still lacking. We explored the relationship between perioperative EEG spectra-derived parameters and POD development, aiming to ascertain the diagnostic utility of these parameters to detect patients developing POD.
METHODS:
Patients aged ≥65 years undergoing elective surgeries that were expected to last more than 60 minutes were included in this prospective, observational single center study (Biomarker Development for Postoperative Cognitive Impairment [BioCog] study). Frontal EEGs were recorded, starting before induction of anesthesia and lasting until recovery of consciousness. EEG data were analyzed based on raw EEG files and downloaded excel data files. We performed multitaper spectral analyses of relevant EEG epochs and further used multitaper spectral estimate to calculate a corresponding spectral parameter. POD assessments were performed twice daily up to the seventh postoperative day. Our primary aim was to analyze the relation between the perioperative spectral edge frequency (SEF) and the development of POD.
RESULTS:
Of the 237 included patients, 41 (17%) patients developed POD. The preoperative EEG in POD patients was associated with lower values in both SEF (POD 13.1 ± 4.6 Hz versus no postoperative delirium [NoPOD] 17.4 ± 6.9 Hz; P = .002) and corresponding γ-band power (POD −24.33 ± 2.8 dB versus NoPOD −17.9 ± 4.81 dB), as well as reduced postinduction absolute α-band power (POD −7.37 ± 4.52 dB versus NoPOD −5 ± 5.03 dB). The ratio of SEF from the preoperative to postinduction state (SEF ratio) was ~1 in POD patients, whereas NoPOD patients showed a SEF ratio >1, thus indicating a slowing of EEG with loss of unconscious. Preoperative SEF, preoperative γ-band power, and SEF ratio were independently associated with POD (P = .025; odds ratio [OR] = 0.892, 95% confidence interval [CI], 0.808–0.986; P = .029; OR = 0.568, 95% CI, 0.342–0.944; and P = .009; OR = 0.108, 95% CI, 0.021–0.568, respectively).
CONCLUSIONS:
Lower preoperative SEF, absence of slowing in EEG while transitioning from preoperative state to unconscious state, and lower EEG power in relevant frequency bands in both these states are related to POD development. These findings may suggest an underlying pathophysiology and might be used as EEG-based marker for early identification of patients at risk to develop POD.
Objective:
The cervical mucus plugs are enriched with proteins of known immunological functions. We aimed to characterize the anti-HIV-1 activity of the cervical mucus plugs against a panel of different HIV-1 strains in the contexts of cell-free and cell-associated virus.
Design:
A cohort of consenting HIV-1-negative and HIV-1-positive pregnant women in labour was recruited from Mthatha General Hospital in the Eastern Cape province of South Africa, from whom the cervical mucus plugs were collected in 6 M guanidinium chloride with protease inhibitors and transported to our laboratories at −80 °C.
Methods:
Samples were centrifuged to remove insoluble material and dialysed before freeze--drying and subjecting them to the cell viability assays. The antiviral activities of the samples were studied using luminometric reporter assays and flow cytometry. Time-of-addition and BlaM-Vpr virus-cell fusion assays were used to pin-point the antiviral mechanisms of the cervical mucus plugs, before proteomic profiling using liquid chromatography-tandem mass spectrometry.
Results:
The proteinaceous fraction of the cervical mucus plugs exhibited anti-HIV-1 activity with inter-individual variations and some degree of specificity among different HIV-1 strains. Cell-associated HIV-1 was less susceptible to inhibition by the potent samples whenever compared with the cell-free HIV-1. The samples with high antiviral potency exhibited a distinct proteomic profile when compared with the less potent samples.
Conclusion:
The crude cervical mucus plugs exhibit anti-HIV-1 activity, which is defined by a specific proteomic profile.
Background:
Cardiac surgery patients represent a high-risk cohort in intensive care units (ICUs). Central venous pressure (CVP) measurement seems to remain an integral part in hemodynamic monitoring, especially in cardio-surgical ICUs. However, its value as a prognostic marker for organ failure is still unclear. Therefore, we analyzed postoperative CVP values after adult cardiac surgery in a large cohort with regard to its prognostic value for morbidity and mortality.
Methods:
All adult patients admitted to our ICUs between 2006 and 2019 after cardiac surgery were eligible for inclusion in the study (n = 11,198). We calculated the median initial CVP (miCVP) after admission to the ICU, which returned valid values for 9802 patients. An ROC curve analysis for optimal cut-off miCVP to predict ICU mortality was conducted with consecutive patient allocation into a (a) low miCVP (LCVP) group (≤11 mmHg) and (b) high miCVP (HCVP) group (>11 mmHg). We analyzed the impact of high miCVP on morbidity and mortality by propensity score matching (PSM) and logistic regression.
Results:
ICU mortality was increased in HCVP patients. In addition, patients in the HCVP group required longer mechanical ventilation, had a higher incidence of acute kidney injury, were more frequently treated with renal replacement therapy, and showed a higher risk for postoperative liver dysfunction, parametrized by a postoperative rise of ≥ 10 in MELD Score. Multiple regression analysis confirmed HCVP has an effect on postoperative ICU-mortality and intrahospital mortality, which seems to be independent.
Conclusions:
A high initial CVP in the early postoperative ICU course after cardiac surgery is associated with worse patient outcome. Whether or not CVP, as a readily and constantly available hemodynamic parameter, should promote clinical efforts regarding diagnostics and/or treatment, warrants further investigations.
Preoperative medication use and development of postoperative delirium and cognitive dysfunction
(2021)
Postoperative delirium (POD) and postoperative (neuro-)cognitive disorder (POCD) are frequent and serious complications after operations. We aim to investigate the association between pre-operative polypharmacy and potentially inappropriate medications and the development of POD/POCD in elderly patients. This investigation is part of the European BioCog project (www.biocog.eu), a prospective multicenter observational study with elderly surgical patients. Patients with a Mini-Mental State Examination score less than or equal to 23 points were excluded. POD was assessed up to 7 days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method (for the intensive care unit [ICU]), and a patient chart review. POCD was assessed 3 months after surgery with a neuropsychological test battery. Pre-operative long-term medication was evaluated in terms of polypharmacy (≥5 agents) and potentially inappropriate medication (defined by the PRISCUS and European list of potentially inappropriate medications [EU(7)-PIM] lists), and associations with POD and POCD were analyzed using logistic regression analysis. Eight hundred thirty-seven participants were included for analysis of POD and 562 participants for POCD. Of these, 165 patients (19.7%) fulfilled the criteria of POD and 60 (10.7%) for POCD. After adjusting for confounders, pre-operative polypharmacy and intake of potentially inappropriate medications could not be shown to be associated with the development of POD nor POCD. We found no associations between pre-operative polypharmacy and potentially inappropriate medications and development of POD and POCD. Future studies should focus on the evaluation of drug interactions to determine whether patients benefit from a pre-operative adjustment.
Background:
Etomidate is typically used as an induction agent in cardiac surgery because it has little impact on hemodynamics. It is a known suppressor of adrenocortical function and may increase the risk for post-operative infections, sepsis, and mortality. The aim of this study was to evaluate whether etomidate increases the risk of postoperative sepsis (primary outcome) and infections (secondary outcome) compared to propofol.
Methods:
This was a retrospective before–after trial (IRB EA1/143/20) performed at a tertiary medical center in Berlin, Germany, between 10/2012 and 01/2015. Patients undergoing cardiac surgery were investigated within two observation intervals, during which etomidate and propofol were the sole induction agents.
Results:
One-thousand, four-hundred, and sixty-two patients, and 622 matched pairs, after caliper propensity-score matching, were included in the final analysis. Sepsis rates did not differ in the matched cohort (etomidate: 11.5% vs. propofol: 8.2%, p = 0.052). Patients in the etomidate interval were more likely to develop hospital-acquired pneumonia (etomidate: 18.6% vs. propofol: 14.0%, p = 0.031).
Conclusion:
Our study showed that a single-dose of etomidate is not statistically associated with higher postoperative sepsis rates after cardiac surgery, but is associated with a higher incidence of hospital-acquired pneumonia. However, there is a notable trend towards a higher sepsis rate.
The benzodiazepine, midazolam, is one of the most frequently used sedatives in intensive care medicine, but it has an unfavorable pharmacokinetic profile when continuously applied. As a consequence, patients are frequently prolonged and more deeply sedated than intended. Due to its distinct pharmacological features, including a cytochrome P450-independent metabolization, intravenous lormetazepam might be clinically advantageous compared to midazolam. In this retrospective cohort study, we compared patients who received either intravenous lormetazepam or midazolam with respect to their survival and sedation characteristics. The cohort included 3314 mechanically ventilated, critically ill patients that received one of the two drugs in a tertiary medical center in Germany between 2006 and 2018. A Cox proportional hazards model with mortality as outcome and APACHE II, age, gender, and admission mode as covariates revealed a hazard ratio of 1.75 [95% CI 1.46–2.09; p < 0.001] for in-hospital mortality associated with the use of midazolam. After additionally adjusting for sedation intensity, the HR became 1.04 [95% CI 0.83–1.31; p = 0.97]. Thus, we concluded that excessive sedation occurs more frequently in critically ill patients treated with midazolam than in patients treated with lormetazepam. These findings require further investigation in prospective trials to assess if lormetazepam, due to its ability to maintain light sedation, might be favorable over other benzodiazepines for sedation in the ICU.
Many people across the world suffer from iodine (I) deficiency and related diseases. The I content in plant-based foods is particularly low, but can be enhanced by agronomic biofortification. Therefore, in this study two field experiments were conducted under orchard conditions to assess the potential of I biofortification of apples and pears by foliar fertilization. Fruit trees were sprayed at various times during the growing season with solutions containing I in different concentrations and forms. In addition, tests were carried out to establish whether the effect of I sprays can be improved by co-application of potassium nitrate (KNO3) and sodium selenate (Na2SeO4). Iodine accumulation in apple and pear fruits was dose-dependent, with a stronger response to potassium iodide (KI) than potassium iodate (KIO3). In freshly harvested apple and pear fruits, 51% and 75% of the biofortified iodine was localized in the fruit peel, respectively. The remaining I was translocated into the fruit flesh, with a maximum of 3% reaching the core. Washing apples and pears with running deionized water reduced their I content by 14%. To achieve the targeted accumulation level of 50–100 μg I per 100 g fresh mass in washed and unpeeled fruits, foliar fertilization of 1.5 kg I per hectare and meter canopy height was required when KIO3 was applied. The addition of KNO3 and Na2SeO4 to I-containing spray solutions did not affect the I content in fruits. However, the application of KNO3 increased the total soluble solids content of the fruits by up to 1.0 °Brix compared to the control, and Na2SeO4 in the spray solution increased the fruit selenium (Se) content. Iodine sprays caused leaf necrosis, but without affecting the development and marketing quality of the fruits. Even after three months of cold storage, no adverse effects of I fertilization on general fruit characteristics were observed, however, I content of apples decreased by 20%.
Äpfel besitzen mehrere Allergene, die beim Essen innerhalb von 5–10 min zu Symptomen im Mundbereich führen – und deshalb von Apfelallergikern nicht gegessen werden können. In Deutschland haben rund 7,5 Mio. Menschen spezifische Antikörper gegen das Hauptallergen (Mal d 1) in Äpfeln entwickelt und sind damit sensibilisiert. Mindestens 3,5 Mio. von ihnen entwickeln die teilweise erheblichen allergischen Symptome als Ausdruck eines Oralen Allergie-Syndroms. Es gibt bisher keine medikamentöse Therapie gegen diese Allergie.
Apfelallergiker können daher nur auf Äpfel ganz verzichten, oder vorher erhitzte Äpfel essen oder Sorten suchen, die wenig Allergene enthalten und deshalb als allergikerfreundliche Apfelsorten bezeichnet werden können.
Alleinige Bestimmungen von Allergenen im Labor können nicht voraussagen, ob ein Apfel ohne allergische Symptome von Apfelallergikern gegessen werden kann; dazu bedarf es klinischer Prüfungen.
Wir beschreiben eine standardisierte klinische, orale Provokationstestung, die zur Charakterisierung eines allergenarmen, allergikerfreundlichen Apfels bzw. Apfelsorte benutzt werden kann.. Die Ergebnisse solcher mindestens dreijährigen Tests können zur Verleihung des ECARF-Siegels für allergikerfreundliche Produkte genutzt werden.
Background: In longitudinal studies, observations are made over time. Hence, the single observations at each time point are dependent, making them a repeated measurement. In this work, we explore a different, counterintuitive setting: At each developmental time point, a lethal observation is performed on the pregnant or nursing mother. Therefore, the single time points are independent. Furthermore, the observation in the offspring at each time point is correlated with each other because each litter consists of several (genetically linked) littermates. In addition, the observed time series is short from a statistical perspective as animal ethics prevent killing more mother mice than absolutely necessary, and murine development is short anyway. We solve these challenges by using multiple contrast tests and visualizing the change point by the use of confidence intervals.
Results: We used linear mixed models to model the variability of the mother. The estimates from the linear mixed model are then used in multiple contrast tests.There are a variety of contrasts and intuitively, we would use the Changepoint method. However, it does not deliver satisfying results. Interestingly, we found two other contrasts, both capable of answering different research questions in change point detection: i) Should a single point with change direction be found, or ii) Should the overall progression be determined? The Sequen contrast answers the first, the McDermott the second. Confidence intervals deliver effect estimates for the strength of the potential change point. Therefore, the scientist can define a biologically relevant limit of change depending on the research question.
Conclusion: We present a solution with effect estimates for short independent time series with observations nested at a given time point. Multiple contrast tests produce confidence intervals, which allow determining the position of change points or to visualize the expression course over time. We suggest to use McDermott’s method to determine if there is an overall significant change within the time frame, while Sequen is better in determining specific change points. In addition, we offer a short formula for the estimation of the maximal length of the time series.
Background
There is no consensus on the instruments for diagnosis of post-intensive care syndrome (PICS). We present a proposal for a set of outcome measurement instruments of PICS in outpatient care.
Methods
We conducted a three-round, semi-structured consensus-seeking process with medical experts, followed each by exploratory feasibility investigations with intensive care unit survivors (n1 = 5; n2 = 5; n3 = 7). Fourteen participants from nine stakeholder groups participated in the first and second consensus meeting. In the third consensus meeting, a core group of six clinical researchers refined the final outcome measurement instrument set proposal.
Results
We suggest an outcome measurement instrument set used in a two-step process. First step: Screening with brief tests covering PICS domains of (1) mental health (Patient Health Questionnaire-4 (PHQ-4)), (2) cognition (MiniCog, Animal Naming), (3) physical function (Timed Up-and-Go (TUG), handgrip strength), and (4) health-related quality of life (HRQoL) (EQ-5D-5L). Single items measure subjective health before and after the intensive care unit stay. If patients report new or worsened health problems after intensive care unit discharge and show relevant impairment in at least one of the screening tests, a second extended assessment follows: (1) Mental health (Patient Health Questionnaire-8 (PHQ-8), Generalized Anxiety Disorder Scale-7 (GAD-7), Impact of Event Scale – revised (IES-R)); (2) cognition (Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Trail Making Test (TMT) A and B); (3) physical function (2-Minute Walk Test (2-MWT), handgrip strength, Short Physical Performance Battery (SPPB)); and (4) HRQoL (EQ-5D-5L, 12-Item WHO Disability Assessment Schedule (WHODAS 2.0)).
Conclusions
We propose an outcome measurement instrument set used in a two-step measurement of PICS, combining performance-based and patient-reported outcome measures. First-step screening is brief, free-of-charge, and easily applicable by health care professionals across different sectors. If indicated, specialized healthcare providers can perform the extended, second-step assessment. Usage of the first-step screening of our suggested outcome measurement instrument set in outpatient clinics with subsequent transfer to specialists is recommended for all intensive care unit survivors. This may increase awareness and reduce the burden of PICS.
Background
A pre-existing neurocognitive disorder (NCD) is a relevant factor for the outcome of surgical patients. To improve understanding of these conditions, we investigated the association between parameters of the cholinergic system and NCD.
Method
This investigation is part of the BioCog project (www.biocog.eu), which is a prospective multicenter observational study including patients aged 65 years and older scheduled for elective surgery. Patients with a Mini-Mental State Examination (MMSE) score ≤23 points were excluded. Neurocognitive disorder was assessed according to the fifth Diagnostic and Statistical Manual of Mental Disorders criteria. The basal forebrain cholinergic system volume (BFCSV) was assessed with magnetic resonance imaging, the peripheral cholinesterase (ChE) activities with point-of-care measurements, and anticholinergic load by analyzing the long-term medication with anticholinergic scales (Anticholinergic Drug Scale [ADS], Anticholinergic Risk Scale [ARS], Anticholinergic Cognitive Burden Scale [ACBS]). The associations of BFCSV, ChE activities, and anticholinergic scales with NCD were studied with logistic regression analysis, adjusting for confounding factors.
Results
A total of 797 participants (mean age 72 years, 42% females) were included. One hundred and eleven patients (13.9%) fulfilled criteria for mild NCD and 82 patients (10.3%) for major NCD criteria. We found that AcetylChE activity was associated with major NCD (odds ratio [95% confidence interval]: [U/gHB] 1.061 [1.010, 1.115]), as well as ADS score ([points] 1.353 [1.063, 1.723]) or ARS score, respectively ([points] 1.623 [1.100, 2.397]) with major NCD. However, we found no association between BFCSV or ButyrylChE activity with mild or major NCD.
Conclusions
AcetylChE activity and anticholinergic load were associated with major NCD. Future research should focus on the association of the cholinergic system and the development of postoperative delirium and postoperative NCD.
Acute post-operative delirium (POD) and long-term post-operative cognitive dysfunction (POCD) are frequent and associated with increased mortality, dependency on care giving and institutionalization rates. The POCD-related cost burden on the German long-term care insurance provides an indication for the savings potential from risk-adapted treatment schemes. Comprehensive estimates have not been assessed or published so far.
A model-based cost-analysis was designed to estimate POCD-related costs in the long-term care insurance. Comprehensive analysis of inpatient operations and procedures (OPS-codes) served as the base for case number calculations, which were then used as input to the actual cost model. POCD-incidence rates were obtained from the BioCog study. Various sensitivity analyses were performed to assess uncertainty of the model results.
Total POCD related annual costs in the German long-term care insurance account for approximately 1.6 billion EUR according to the base case of our analysis. Total annual costs for all POCD cases depend on surgery numbers, incidence rates, other assumptions, and uncertain input parameters.
The financial burden to the long-term care insurance is substantial, even in a conservative scenario of the cost model. Variability of results stems from uncertain assumptions, POCD-incidence rates and from uncertain patient numbers who are undergoing surgery and are therefore at risk to develop POCD.
The effect of pulsed electric field (PEF) and ultrasound (US) on the frying behavior of potato chips was investigated. For this purpose, a special fryer with a window was designed to enable the investigation of water evaporation by the characterization of bubble formation during frying. The number of water vapor bubbles and the bubble volume distribution were analyzed in order to gain an insight into heat and mass transfer affected by PEF and US treatment. Quality parameters of the potato chips such as moisture, fat and acrylamide content were measured. Overall, the results of this study show for the first time impacting effects on the frying process that can be achieved by combining PEF as a volumetric cell disintegration technology and ultrasound as a mean to affect interface phenomena. The obtained results can be used to further optimize frying processes used for the production of chips and other products.
While the Food and Biotechnology industries often use unit operations that have been known for some time, sometimes these processes are not efficient or sustainable. The need to develop more efficient processing lines to obtain higher quality products is of utmost importance. Over the last years, pulsed electric fields (PEF) processing has attracted the interest of numerous researchers and companies due to its ability to reduce processing time, preserve thermolabile compounds, which are responsible for the aroma, nutritional and bioactive properties of food products.
Therefore, in this article, some of the most important studies regarding the application of PEF technology in food and biotechnology processing is discussed.
Background and Objectives
Despite the long-standing consensus on the importance of tumor size, tumor number and carcinoembryonic antigen (CEA) levels as predictors of long-term outcomes among patients with colorectal liver metastases (CRLM), optimal prognostic cut-offs for these variables have not been established.
Methods
Patients who underwent curative-intent resection of CRLM and had available data on at least one of the three variables of interest above were selected from a multi-institutional dataset of patients with known KRAS mutational status. The resulting cohort was randomly split into training and testing datasets and recursive partitioning analysis was employed to determine optimal cut-offs. The concordance probability estimates (CPEs) for these optimal cut offs were calculated and compared to CPEs for the most widely used cut-offs in the surgical literature.
Results
A total of 1643 patients who met eligibility criteria were identified. Following recursive partitioning analysis in the training dataset, the following cut-offs were identified: 2.95 cm for tumor size, 1.5 for tumor number and 6.15 ng/ml for CEA levels. In the entire dataset, the calculated CPEs for the new tumor size (0.52), tumor number (0.56) and CEA (0.53) cut offs exceeded CPEs for other commonly employed cut-offs.
Conclusion
The current study was able to identify optimal cut-offs for the three most commonly employed prognostic factors in CRLM. While the per variable gains in discriminatory power are modest, these novel cut-offs may help produce appreciable increases in prognostic performance when combined in the context of future risk scores.
Background
Postoperative delirium (POD) is a frequent and serious complication after surgery. Evidence of a relationship between anticholinergic medication and the development of delirium is inconclusive, but studies on POD are rare.
Objectives
The objective of this study was to evaluate the anticholinergic load of preoperative medication in older adult patients and its association with the development of POD.
Methods
This investigation was part of the European BioCog project (http://www.biocog.eu), a prospective multicenter observational study in older adult surgical patients (ClinicalTrials.gov identifier: NCT02265263, 15 October 2014). Patients with a Mini–Mental State Examination score ≤ 23 points were excluded. POD was assessed up to 7 days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method and a patient chart review. The preoperative anticholinergic load was calculated using the Anticholinergic Drug Scale (ADS), the Anticholinergic Risk Scale (ARS) and the Anticholinergic Cognitive Burden Scale (ACBS), and associations with POD were analyzed using logistic regression analysis adjusting for age, comorbidities, duration of anesthesia and number of drugs used.
Results
In total, 837 participants were included for analysis, and 165 patients (19.7%) fulfilled the criteria of POD. After adjusting for confounders, we found no association between preoperative anticholinergic load and the development of POD (ADS [points] odds ratio [OR] 0.928; 95% confidence interval [CI] 0.749–1.150; ARS [points] OR 0.832; 95% CI 0.564–1.227; ACBS [points] OR 1.045; 95% CI 0.842–1.296).
Conclusion
This study found no association between the anticholinergic load of drugs used preoperatively and the development of POD in older adult patients without severe preexisting cognitive impairment. Future analyses should examine the influence of intra- and postoperative administration of anticholinergic drugs as well as dosages of and interactions between medications.
This chapter provides an overview of the gender aspects that are relevant to Talent Management, acknowledging gender as a social construction of the purportedly adequate behaviors and traits exhibited by males and females as the result of education and socialization processes. It discusses gendered perspectives and the needs of current and future key players, such as work–family balance and dual-career challenges, because they influence the decisions of talent to join, remain with, or leave organizations. The chapter focuses on well-qualified female professionals who are willing to invest in themselves and value their significant involvement in their work. By applying a gender lens, it addresses a gap in the Talent Management discussion and aims to contribute to the development of Talent Management on both the theoretical and practical level. If Talent Mangement systematically includes employees in mid- and late career and enables them to learn throughout their careers, it will expand its target groups.
Der vorliegende Expertenstandard ist eine Zusammenführung des Expertenstandard "Schmerzmanagement in der Pflege bei akuten Schmerzen, 1. Aktualisierung 2011" und des Expertenstandards "Schmerzmanagement in der Pflege bei chronischen Schmerzen, Entwicklung - Konsentierung - Implementierung" im Rahmen der gemeinsamen Aktualisierung.
Background
Diabetes mellitus is a major global health issue with a growing prevalence. In this context, the number of diabetic complications is also on the rise, such as diabetic foot ulcers (DFU), which are closely linked to the risk of lower extremity amputation (LEA). Statistical prediction tools may support clinicians to initiate early tertiary LEA prevention for DFU patients. Thus, we designed Bayesian prediction models, as they produce transparent decision rules, quantify uncertainty intuitively and acknowledge prior available scientific knowledge.
Method
A logistic regression using observational collected according to the standardised PEDIS classification was utilised to compute the six-month amputation risk of DFU patients for two types of LEA: 1.) any-amputation and 2.) major-amputation. Being able to incorporate information which is available before the analysis, the Bayesian models were fitted following a twofold strategy. First, the designed prediction models waive the available information and, second, we incorporated the a priori available scientific knowledge into our models. Then, we evaluated each model with respect to the effect of the predictors and validity of the models. Next, we compared the performance of both models with respect to the incorporation of prior knowledge.
Results
This study included 237 patients. The mean age was 65.9 (SD 12.3), and 83.5% were male. Concerning the outcome, 31.6% underwent any- and 12.2% underwent a major-amputation procedure. The risk factors of perfusion, ulcer extent and depth revealed an impact on the outcomes, whereas the infection status and sensation did not. The major-amputation model using prior information outperformed the uninformed counterpart (AUC 0.765 vs AUC 0.790, Cohen’s d 2.21). In contrast, the models predicting any-amputation performed similarly (0.793 vs 0.790, Cohen’s d 0.22).
Conclusions
Both of the Bayesian amputation risk models showed acceptable prognostic values, and the major-amputation model benefitted from incorporating a priori information from a previous study. Thus, PEDIS serves as a valid foundation for a clinical decision support tool for the prediction of the amputation risk in DFU patients. Furthermore, we demonstrated the use of the available prior scientific information within a Bayesian framework to establish chains of knowledge.
Warum engagieren sich manche Menschen für Flüchtlinge, während andere sich gegen die Flüchtlingsaufnahme einsetzen? Auf der Suche nach einer Antwort führen die Autor/innen deutschlandweit Interviews mit Engagierten beider Seiten und erhalten tiefergehenden Einblick in deren Tätigkeiten. Mit offener Haltung werden Motive und Ziele beider Seiten erforscht, aufgezeigt und verglichen. Um dabei ein besseres Verständnis der individuellen Sichtweisen zu ermöglichen, werden die Ergebnisse in einem psychologischen Kontext betrachtet. Es wird deutlich, dass beide Seiten verschiedene Strategien für den Umgang mit Unsicherheit, die die Flüchtlingsthematik mit sich bringt, verfolgen. Obwohl sich beide Seiten eigentlich einen fairen Dialog miteinander wünschen, sind sie durch negative Erfahrungen oder Vorurteile sehr in ihrer Position festgefahren. Aber neben den offensichtlichen Unterschieden zwischen beiden Engagementorientierungen werden auch überraschende Ähnlichkeiten und Dialogmöglichkeiten aufgedeckt. Dieses Buch ist der erste von zwei Bänden zu diesem Forschungsprojekt und bietet den Leser/innen einen spannenden Einblick in das Denken und Handeln der Engagierten.
In der Schriftenreihe „Voneinander Lehren lernen“, die vom LearningCenter der Hochschule Osnabrück herausgegeben wird, werden anwendungsbezogene Beiträge zur Qualitätsentwicklung in Studium und Lehre publiziert. Die Schriftenreihe ist an das hochschuldidaktische Konzept des „Scholarship of Teaching and Learning“ angelehnt. Demnach soll sie insbesondere den Fachlehrenden verschiedener Studiengänge als Plattform dienen, um ihre eigenen Erfahrungen, Ideen und Konzepte zur Lehr- und Studiengangentwicklung systematisch zu reflektieren und entsprechende Erkenntnisse für andere nutzbar zu machen. Ziel ist es, den Diskurs über hochschuldidaktische Themen in die Fächer zu tragen und so nachhaltig zu einer hohen Qualität der Lehr-Lernprozesse in den Studiengängen beizutragen. Ergänzt werden die Texte der Fachlehrenden zum Teil durch Beiträge von Mitarbeiter*innen der im Bereich Studium und Lehre tätigen Organisationseinheiten. Bislang ist die Schriftenreihe eng an das Lehrkolleg der Hochschule Osnabrück gekoppelt. Dabei handelt es sich um ein Angebotsformat des LearningCenters, in dem Professor*innen und Lehrkräfte für besondere Aufgaben die Möglichkeit haben, unter hochschuldidaktischer Begleitung innovative Lehrentwicklungsprojekte in ihren eigenen Lehrveranstaltungen und Modulen umzusetzen. Dieser zweite Band der Schriftenreihe enthält Beiträge von Teilnehmer*innen des Lehrkollegs 2019/20, in dessen Rahmen verschiedene Maßnahmen zum Thema „Projekte im Studium“ umgesetzt und evaluiert wurden.
Die meisten börsennotierten Gesellschaften haben ein Risikofrüherkennungssystem, das vom Abschlussprüfer ohne den Verweis auf schwerwiegende Mängel testiert wird. Tatsächlich zeigen Studien, dass die in der Praxis implementierten Systeme häufig ungeeignet sind, um an sich erkennbare bestandsgefährdende Entwicklungen zu identifizieren. Dies liegt an methodischen Schwächen, z. B. an einer fehlenden Betrachtung der Liquiditätswirkung von Risiken, einer vernachlässigten Analyse von Extremrisiken und insb. am Fehlen einer Risikoaggregation, die auch Kombinationseffekte berücksichtigt. Bei Insolvenzen, wie hier im Beispiel von Gerry Weber, lässt sich bei Betrachtung des dokumentierten Risikomanagementsystems erkennen, dass die gesetzlichen Anforderungen nicht erfüllt wurden. Um solche „überraschenden Insolvenzen“ zu vermeiden, ist es erforderlich, bessere Verfahren zu implementieren und durch Prüfer testieren zu lassen, was bisher nicht konsequent geschieht. Der Beitrag schlägt ein einfaches aber umfassendes Prüfschema für Risikofrüherkennungssysteme vor, das sowohl intern als auch von externen Prüfern verwendet werden kann.
Die folgende Studie wurde vor dem Hintergrund der zunehmenden Relevanz von ökologisch nachhaltigem Handeln in unserer Gesellschaft aufgrund von wachsenden erlebbaren Auswirkungen durch unsere Lebensweise und den Klimawandel durchgeführt. Für die folgende qualitative Studie wurden fünf Studierende und fünf Berufstätige zu den Hintergründen ihres ökologisch nachhaltigen Handelns befragt. Es wurden zehn Einflussfaktoren identifiziert, welche ökologisch nachhaltiges Handeln von Studierenden und Berufstätigen beeinflussen: Wissen & Informationen; Persönliche Relevanz; empfundene Wichtigkeit & Interesse; Erlebnisse & Erfahrungen (auch ehrenamtliches Engagement); Soziale Umfelder (persönliches, studentisches und berufliches Umfeld); Beeinflussung durch Andere (auch Beeinflussung durch Medien); Positiver Nutzen; Abwägung; Gewohnheiten; Gefühle; Möglichkeiten zur Umsetzung. Als theoretische Basis zur Untersuchung von beeinflussenden Faktoren wurde das psychologische Modell zur Erklärung nachhaltigen Handelns von Hamann, Baumann und Löschinger (2016) hinzugezogen. Des Weiteren wurden drei Aspekte zur positiven Auswirkung von ökologisch nachhaltigem Handeln zur Förderung ökologisch nachhaltigen Handelns in der Gesellschaft gefunden: fortlaufender Prozess; Beeinflussung von Anderen; Ideen zur Förderung von ökologisch nachhaltigem Handeln. Weitere Maßnahmenvorschläge und Handlungsempfehlungen wurden v. a. für die Kontexte Beruf, Studium, Schule und Medien aus den Erkenntnissen der Studie abgeleitet.
Durch die Verbreitung von VR und den möglichen Potenzialen für die Landschaftsarchitektur, gewinnt die Auseinandersetzung mit der Verwendung als Präsentationsmedium an Relevanz. Aufgrund der geringen Anzahl an Fallstudien zu dieser Thematik, war es das Ziel dieser Arbeit, eine vollständige und praxisnahe VR-Erfahrung anhand eines Beispielprojekts zu erstellen. Hierfür wurde das Wohnbauprojekt „Teilerhöfe“ in Hannover ausgewählt.
Im Rahmen der Arbeit konnte ein Arbeitsablauf für die Erstellung einer VR-Erfahrung aufgestellt und erfolgreich durchgeführt werden. Das Ergebnis bildet eine auf der Unreal Engine basierende virtuelle Echtzeit-Umgebung, die durch ein VR-Headset erkundet werden kann. Trotz einiger notwendiger Kompromisse konnten alle Inhalte des Entwurfs angemessen dargestellt werden. Auf dieser Basis werden mögliche Potenziale und Grenzen für den Einsatz in der Landschaftsarchitektur diskutiert. Hieraus resultiert die Erkenntnis, das VREs einen erheblichen Mehrwert bieten können, aber mit Bedacht eingesetzt werden sollten.
Various overoxidized poly(1H-pyrrole) (PPy), poly(N-methylpyrrole) (PMePy) or poly(3,4-ethylenedioxythiophene) (PEDOT) membranes incorporated into an acrylate-based solid polymer electrolyte matrix (SPE) were directly electrosynthesized by a two-step in situ procedure. The aim was to extend and improve fundamental properties of pure SPE materials. The polymer matrix is based on the cross-linking of glycerol propoxylate (1PO/OH) triacrylate (GPTA) with poly(ethylene glycol) diacrylate (PEGDA) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) as a conducting salt. A self-standing and flexible polymer electrolyte film is formed during the UV-induced photopolymerization of the acrylate precursors, followed by an electrochemical polymerization of the conducting polymers to form a 3D-IPN. The electrical conductivity of the conducting polymer is destroyed by electrochemical overoxidation in order to convert the conducting polymer into an ion-exchange membrane by introduction of electron-rich groups onto polymer units. The resulting polymer films were characterized by scanning electron microscopy, cyclic voltammetry, electrochemical impedance spectroscopy, differential scanning calorimetry, thermal analysis and infrared spectroscopy. The results of this study show that the combination of a polyacrylate-matrix with ion selective properties of overoxidized CPs leads to new 3D materials with higher ionic conductivity than SPEs and separator or selective ion-exchange membrane properties with good stability by facile fabrication.
The simulation of the residual stress field achieved by shot peening cannot be carried out on component-large models. Hence, an efficient unit cell model for the simulation of the shot peening process is developed. The model allows both, the simple inclusion of a pre-stress and the evaluation of the up-arching of the Almen strip. For this purpose, generalized coupling constraints for the periodic boundaries of the unit cell are developed. These allow for displacement and rotation of the coupled boundaries relative to each other. In the coupling constraints, this is accomplished by respective variables, which can either be prescribed to the analysis or read out as a result from the analysis. Hence, the unit cell can expand, shear, bend and twist under driving forces like, e. g., residual stresses or thermal effects. At the same time, deformations of the cell’s periodic boundary pairs are kept congruent by the generalized coupling. The ability to cover expansion is novel regarding known periodic boundary conditions. Also, the application of a generalized unit cell to shot peening is new.
Results obtained with the generalized unit cell are displayed, demonstrating its capabilities: A fundamental analysis of the residual stress field from shot peening shows inhomogeneities at a fatigue relevant level to be inevitable. A validation of the model was done by comparison with experimental Almen strip shot peening tests reported in literature. Shot peening under pre-stress is demonstrated and its results in terms of residual stress are evaluated. The application of the generalized unit cell is not limited to shot peening.
Der britische Historiker und Soziologe Cyril Northcote Parkinson hat vor mehr als sechzig Jahren die ersten nach ihm benannten Gesetze veröffentlicht. Es liegt die Annahme nahe, dass Parkinsons Gesetze auf fundamentalen Bias-Formen, also systematischen Urteilsfehlern des Menschen, basieren, die erst später im Rahmen der Verhaltenspsychologie beschrieben wurden. Diese Verbindung zwischen Soziologie und Psychologie wird auf Grundlage der Recherche erstmals gezogen und belegt. Für sechs von Parkinsons Gesetze werden knapp drei Dutzend Biases und andere Formen von Urteilsfehlern benannt.
Diese mehr als dreißig Verzerrungen erweisen sich als eine fundierte Begründung für die fortgesetzte Gültigkeit der Gesetze. Sie zeigen, dass Parkinsons Gesetze ihren Ursprung in ganz erheblichem Maße in intrapersonellen Denkfehlern haben. Dass Parkinsons Gesetze nicht deterministisch wirken, zeigen die vorgeschlagenen Maßnahmen zum Ende der Arbeit.Gleichwohl die Botschaften von Parkinson auf Dauer gültig sein werden, kann ihnen aktiv begegnet werden, um die Folgen zu minimieren.
In der vorliegenden Arbeit wurde die Frage diskutiert, ob die Kommunikation der Regierung beziehungsweise der Gesundheitsministerien in einer Pandemie ausschlaggebend sind für die Zufrieden-heit der Bürger in der Krisensituation. Hierfür wurde die Kommunikation der Gesundheitsministe-rien der Länder Deutschland, Großbritannien und der USA untersucht. Kommunikation in der Krisensituation zeichnet sich vor allem durch ihren akuten und reagierenden Charakter aus. Der Zeit-raum des Ausbruchs der COVID-19-Pandemie, Ende des Jahres 2019 bis zum 31.03.2020, wurde zur Untersuchung gewählt. Die Länder und die Kommunikation wurden vorgestellt und die Kommunikationen, anhand einer Orientierung an den Kategorien der Krisenkommunikation der WHO, eingeordnet. Diese Einordnung hat die Kommunikationen vergleichbarer und übersichtlicher gestaltet. Im weiteren Verlauf wurde die Zufriedenheit mit der Reaktion der Regierung auf die COVID-19-Pandemie hinzugezogen. Großbritannien hatte die meisten Kommunikationen und hat am frühesten das COVID-19-Virus thematisiert. Die USA folgten zeitlich und hatten bereits weniger als die Hälfte der Kommunikationen von Großbritannien getätigt. Deutschland berichtete am spätesten und hat etwas mehr als die Hälfte der Kommunikationen von den USA getätigt. Ein kausaler Zusammenhang von Anzahl der Kommunikationen und Zufriedenheit ist für die Gesundheitsministerien nicht zu erkennen. Die Zufriedenheit lag gegen Ende des Beobachtungszeitraumes durchschnittlich in Großbritannien am höchsten, danach folgte Deutschland. Amerikaner waren deutlich unzufriedener. Inhaltlich ließen sich teilweise parallelen und interessante Unterschiede herausarbeiten. Weitere Untersuchungen zu der Krisenkommunikation in der Pandemie sind notwendig.
Die vorliegende Arbeit ist eine Untersuchung zweier Gitarrenschulen der Klassik mit dem Ziel, damalige pädagogische Ansichten mit heutigen zu vergleichen und festzustellen, inwiefern diese heute noch brauchbar sind. Um zunächst ein Bild dieser Zeit und dieser Epoche zu bekommen, werden wesentliche Merkmale der Klassik zusammengetragen. Dabei soll es um gesellschaftliche Umbrüche und die sich daraus verändernde Bedeutung der Musik gehen. Nach der Vorstellung der beiden Komponisten Fernando Sor und Matteo Carcassi werden die von ihnen geschriebenen Gitarrenschulen auf Unterschiede und Gemeinsamkeiten hin untersucht. Anschließend folgt eine Vorstellung der modernen Gitarrenschule von Jens Kienbaum „Abenteuer Gitarre“. Im Hauptteil dieser Arbeit werden die Ziele sowie die sich daraus ergebenden Inhalte und verwendeten Methoden der historischen Schulen mit der modernen verglichen. Danach wird mithilfe vorher gewonnener Erkenntnisse bewertet, ob und inwiefern die beiden historischen Schulen im heutigen Unterricht noch praktikabel sein könnten. Als Vergleichsobjekt dient der Unterricht mit erwachsenen Laien.
Keywords: Gitarre, Klassik, Gitarrenschule, Pädagogik, Didaktik, Inhalte, Methoden, Fernando Sor, Matteo Carcassi, Jens Kienbaum
Mit welchen Erwartungen blicken die Fridays for Future Osnabrück auf die Hochschule? Wie steht es um die Akzeptanz des autonomen Fahrens? Welche Themen prägen die Debatten um die Landwirtschaft der Zukunft? Und wie gehen Start-ups mit den Herausforderungen der Corona-Pandemie um? Diesen und vielen weiteren Fragen widmet sich der neue Forschungsbericht: „Wie wir die Welt von morgen nachhaltig mitgestalten“.
WIR Journal | Juni 2020
(2020)
Wie hat es Niedersachsens größte Fachhochschule geschafft, aufgrund der Corona-Pandemie von einem Tag auf den anderen von der Präsenz- in die Online-Lehre zu wechseln? Und was bedeutet das eigentlich für Studierende, Lehrende und Mitarbeitende? Diese Frage prägt die aktuelle Ausgabe des WIR-Journals der Hochschule Osnabrück. Prägend für die Hochschule sind und bleiben aber auch Themen wie gesellschaftliches Engagement, innovative Forschungsprojekte und das praxisnahe Studium. Lesen Sie, wie sich die Hochschul-Studierenden Felice Susan Amini und Latim Nobert in Afghanistan und Uganda engagieren, wie Osnabrücker Forscher*innen an einer neuen Apfelsorte oder am Mobilstall der Zukunft arbeiten oder wie studentische Abschlussarbeiten Unternehmen der Region bei ihrer Weiterentwicklung helfen können.
Kugelstrahlen ist ein im Maschinenbau eingesetztes Verfahren zur Steigerung der Ermüdungsfestigkeit. Es wird z. B. bei hochbelasteten Komponenten in der Luft- und Raumfahrt, der Fahrzeugtechnik, im Turbomaschinenbau und weiteren Industriezweigen angewandt. Die Einstellung der Betriebsparameter der Kugelstrahlanalage findet üblicherweise mit kostenintensiven empirischen Versuchen statt, mit dem Ziel, die vorgegebene Druckeigenspannung zu erreichen. In [1, 2] wird auf der Basis einer dort beschriebenen neuartigen Elementarzelle vorgeschlagen, die Almenstreifenaufbiegung als Mittel zur Spezifikation der Verfestigung heranzuziehen. Dazu ist deren Simulation notwendig, welche sich mit der entwickelten Elementarzelle wirtschaftlich bewerkstelligen lässt. In der hier vorliegenden Veröffentlichung werden die der Elementarzelle zugrundeliegenden Finite-Elemente-Netze (FE-Netze) mithilfe von Einzelbe-schussversuchen validiert. Weiterhin wird eine ähnlichkeitsmechanische Betrachtung des Kugelstrahlprozesses zur vereinfachten Parametereinstellung vorgestellt.
Genderbericht 2019
(2020)
Im Professorinnenprogramm III war die Hochschule Osnabrück
doppelt erfolgreich: Ende 2019 wurde unser Gleichstellungszukunftskonzept positiv bewertet. Darüber hinaus wurden wir für unsere geschlechtergerechte Personalentwicklung und -Gewinnung auf dem Weg zur Professur als eine von zehn Hochschulen mit dem Prädikat „Gleichstellung: ausgezeichnet!“ besonders gewürdigt.
Das zeigt: Wir sind auf einem sehr guten Weg. Zugleich ist uns der
Erfolg sowohl Ansporn als auch Verpflichtung, weiterhin intensiv an
einem Kulturwandel auf dem Weg zu mehr Chancengerechtigkeit zu
arbeiten. Statistische Daten über die Verteilung der Geschlechter
in unterschiedlichen Positionen und Fächern geben dabei wichtige
Hinweise für eine erfolgreiche und passgenaue Gleichstellungspolitik.
Der vorliegende Genderbericht zeigt viele positive Entwicklungen,
hält uns allerdings auch vor Augen, an welchen Stellen wir
noch nachjustieren müssen. So konnte der Frauenanteil im Senat
in den vergangenen zehn Jahren von 15 auf 54 Prozent gesteigert
werden. Gleichzeitig liegen wir in der Gruppe der Professuren mit
22,7 Prozent Frauenanteil unter den niedersächsischen und bundesweiten
Vergleichswerten.
Die Verwirklichung von Gleichstellung in Lehre und Forschung birgt
ein großes Potenzial für die Gesellschaft. Die Hochschule Osnabrück wird sich daher weiterhin für die Verbesserung der Repräsentanz von Frauen auf allen Qualifikationsstufen sowie in Bereichen mit geringen Frauenanteilen einsetzen.
Im Rahmen des Forschungsschwerpunktes „Inklusive Bildung“ der Hochschule Osnabrück wurde eine quantitative Erhebung mittels eines schriftlichen Fragebogens durchgeführt.Die Ergebnisse verweisen in vergleichender Perspektive auf unterschiedliche Handlungs- und Sichtweisen der Berufsgruppen hin. Damit ergeben sich verschiedene Chancen sowie Herausforderungen in der Kooperation der Bildungsbereiche – und die Notwendigkeit einer Systematisierung dieser Prozesse.
The central aim of the investigation at hand is to deal with the problem areas of Human Resource Management, which arise by demographic changes and migration. The paper focuses on mutual relationships. Managers and human resource managers are considered as multipliers. Older employees, migrants and women are important potential. Therefore, following research questions have been investigated: Which competences are necessary to promote to recognise the potential of migrants correctly and to promote them? Do the multipliers have to be more sensitized for the issue diversity? Do they have to develop specific competences to make the system more permeable and to make the entry and promotion of migrants possible? Which competences should be promoted to increase the sensitivity for diversity? The questions were examined by a qualitative investigation to develop hypotheses for a quantitative study. Overall, 30 interviews with managers, human resource managers and diversity representatives of the large DAX companies were conducted. Furthermore, 17 employees with immigration background and 15 employees without an immigration background were interviewed. The data was transcribed and analysed by the qualitative content analysis according to Mayring (2010). Comparative analyses were made with single items with Likert Scales. The investigation of managers and employees is a highly diversified issue. Therefore, the main focus of the project lays on the problem areas, conflicts and competences of human resources managers in demographic-sensitive personnel management. In comparison, employees with and without an immigration background were asked. The results show an interesting field of tension between self-perception and perception of others and the assessment of the relevance of diversity attitudes and measures, competences and their implementation. Furthermore, a contrary perception regarding strains and stresses of person with and without immigration background is determined, which is developed in the consequences of migrations stress and experiences of discrimination. The results indicate the need of promotion of competences, especially regarding intercultural competence. A critical analysis of the results will be presented.