Refine
Year of publication
Document Type
- Article (87)
- Bachelor Thesis (56)
- Master's Thesis (22)
- Book (11)
- Part of a Book (9)
- Report (2)
- Conference Proceeding (1)
- Doctoral Thesis (1)
- Moving Images (1)
- Part of Periodical (1)
Is part of the Bibliography
- no (191) (remove)
Keywords
- Landschaftsarchitektur (5)
- Building Information Modeling (4)
- Pflege (3)
- BIM (2)
- Cognition (2)
- Digitalisierung (2)
- New Work (2)
- 21st century skills (1)
- 3D (1)
- 3D-Modell (1)
Institute
Background
A peripheral venous catheter (PVC) is the most widely used device for obtaining vascular access, allowing the administration of fluids and medication. Up to 25% of adult patients, and 50% of pediatric patients experience a first-attempt cannulation failure. In addition to patient and clinician characteristics, device features might affect the handling and success rates. The objective of the study was to compare the first-attempt cannulation success rate between PVCs with wings and a port access (Vasofix® Safety, B. Braun, abbreviated hereon in as VS) with those without (Introcan® Safety, B. Braun, abbreviated hereon in as IS) in an anesthesiological cohort.
Methods
An open label, multi-center, randomized trial was performed. First-attempt cannulation success rates were examined, along with relevant patient, clinician, and device characteristics with univariate and multivariate analyses. Information on handling and adherence to use instructions was gathered, and available catheters were assessed for damage.
Results
Two thousand three hundred four patients were included in the intention to treat analysis. First-attempt success rate was significantly higher with winged and ported catheters (VS) than with the non-winged, non-ported design (IS) (87.5% with VS vs. 78.2% with IS; PChi < .001). Operators rated the handling of VS as superior (rating of “good” or “very good: 86.1% VS vs. 20.8% IS, PChi < .001). Reinsertion of the needle into the catheter after partial withdrawal—prior or during the catheterization attempt—was associated with an increased risk of cannulation failure (7.909, CI 5.989–10.443, P < .001 and 23.023, CI 10.372–51.105, P < .001, respectively) and a twofold risk of catheter damage (OR 1.999, CI 1.347–2.967, P = .001).
Conclusions
First-attempt cannulation success of peripheral, ported, winged catheters was higher compared to non-ported, non-winged devices. The handling of the winged and ported design was better rated by the clinicians. Needle reinsertions are related to an increase in rates of catheter damage and cannulation failure.
A comparison study on modeling of clustered and overdispersed count data for multiple comparisons
(2021)
Data collected in various scientific fields are count data. One way to analyze such data is to compare the individual levels of the factor treatment using multiple comparisons. However, the measured individuals are often clustered – e.g. according to litter or rearing. This must be considered when estimating the parameters by a repeated measurement model. In addition, ignoring the overdispersion to which count data is prone leads to an increase of the type one error rate. We carry out simulation studies using several different data settings and compare different multiple contrast tests with parameter estimates from generalized estimation equations and generalized linear mixed models in order to observe coverage and rejection probabilities. We generate overdispersed, clustered count data in small samples as can be observed in many biological settings. We have found that the generalized estimation equations outperform generalized linear mixed models if the variance-sandwich estimator is correctly specified. Furthermore, generalized linear mixed models show problems with the convergence rate under certain data settings, but there are model implementations with lower implications exists. Finally, we use an example of genetic data to demonstrate the application of the multiple contrast test and the problems of ignoring strong overdispersion.
Im Rahmen dieser Arbeit sollen anhand der PEFA Bewertung, welche im Jahr 2018 stattfand
und die Qualität des öffentlichen Finanzmanagements der Stadt Osnabrück auf Grundlage von internationalen Standards darstellt, Handlungsempfehlungen zur Verbesserung der Transparenz erarbeitet werden. Die entwickelten Maßnahmen sollen den Grundsätzen der Open Government Partnership entsprechen und die Weiterentwicklung der Stadt Osnabrück,
insbesondere im Bereich der Transparenz, unterstützen. Sie sind somit dem übergeordneten
Begriff Open Data zuzuordnen. Um Handlungsempfehlungen zu erarbeiten, werden aus den insgesamt 31 Leistungsindikatoren mit den verschiedenen Dimensionen, die bewertet wurden, diejenigen ausgesucht, welche schlechter als A bewertet wurden. Die gesamten 31 Leistungsindikatoren wurden im Jahr 2018 von A bis D auf einer vierstufigen Ordinalskala bemessen. Anhand der Leistungsindikatoren, die Verbesserungsbedarf aufweisen, werden Maßnahmen entwickelt, die sowohl die Bewertung der Stadt Osnabrück in der PEFA-Analyse verbessern, als auch die Transparenz, das Bürgerengagement und die Modernisierung der Verwaltung im Mindesten unterstützen, wenn nicht sogar verbessern.
Abschlussbericht zum Ziel.2 NRW-Projekt Veränderte Geschäftsmodelle im Übergang zur Elektromobilität
(2013)
During gestation, the most drastic change in oxygen supply occurs with the onset of ventilation after birth. As the too early exposure of premature infants to high arterial oxygen pressure leads to characteristic diseases, we studied the adaptation of the oxygen sensing system and its targets, the hypoxia-inducible factor- (HIF-) regulated genes (HRGs) in the developing lung. We draw a detailed picture of the oxygen sensing system by integrating information from qPCR, immunoblotting, in situ hybridization, and single-cell RNA sequencing data in ex vivo and in vivo models. HIF1α protein was completely destabilized with the onset of pulmonary ventilation, but did not coincide with expression changes in bona fide HRGs. We observed a modified composition of the HIF-PHD system from intrauterine to neonatal phases: Phd3 was significantly decreased, while Hif2a showed a strong increase and the Hif3a isoform Ipas exclusively peaked at P0. Colocalization studies point to the Hif1a-Phd1 axis as the main regulator of the HIF-PHD system in mouse lung development, complemented by the Hif3a-Phd3 axis during gestation. Hif3a isoform expression showed a stepwise adaptation during the periods of saccular and alveolar differentiation. With a strong hypoxic stimulus, lung ex vivo organ cultures displayed a functioning HIF system at every developmental stage. Approaches with systemic hypoxia or roxadustat treatment revealed only a limited in vivo response of HRGs. Understanding the interplay of the oxygen sensing system components during the transition from saccular to alveolar phases of lung development might help to counteract prematurity-associated diseases like bronchopulmonary dysplasia.
In der digitalisierten Arbeitswelt ermöglichen neue und flexible Informations- und Kommunikationstechnologien (IKT) eine raum- und zeitunabhängige Erreichbarkeit (Albers, 2018). Während die „ständige“ Erreichbarkeit öffentlich kontrovers diskutiert wird, zeigt sich im Bereich des Kommunikationsmanagements, insbesondere hinsichtlich der Untersuchung von Agenturen, eine Forschungslücke (Röttger & Zielmann, 2009). Dieser Beitrag knüpft daran an und liefert empirische sowie praxisnahe Erkenntnisse zur arbeitsbezogenen erweiterten Erreichbarkeit. Mit dem Fokus auf Mitarbeitende in Kommunikationsagenturen wurde untersucht, wie ihre Erreichbarkeit ausfällt und welche Gestaltungsansätze sich im Arbeitskontext daraus ableiten. Zu ihrer Beantwortung wurden qualitative, leitfadengestützte Interviews mit Vollzeitbeschäftigten (n= 10) aus mittelgroßen Agenturen (Größe: 20 bis 50 Beschäftigte, n= 5) durchgeführt und ausgewertet. Die Interviewstudie analysiert Ausmaß, Ursachen, individuelle und betriebliche Umgangsweisen sowie darauf aufbauende Handlungsansätze. Die Ergebnisse verdeutlichen zwei Aspekte der erweiterten Erreichbarkeit in Agenturen: Individualität und Vielfalt. Innerhalb der Untersuchung kann verdeutlicht werden, dass die Erreichbarkeit auf einer Kombination vielfältiger Ursachen beruht. Für die Gestaltung der Erreichbarkeit leiten sich daraus relevante Implikationen ab: Statt verbindlicher Vorschriften sollte ein selbstbestimmtes, flexibles Arbeiten im Vordergrund stehen.
Der Beitrag beschäftigt sich mit dem Rollenverständnis von Lokaljournalisten im Zusammenhang mit dem Stromnetzausbau in Niedersachsen. Diese Akteursgruppe wurde bisher nicht von der Kommunikationswissenschaft beachtet, obwohl ihr eine „Schlüsselrolle“ (Schneider, 2015, S. 67) als Multiplikator im Stromnetzausbau zugeschrieben wird. In der kommunikationswissenschaftlichen Literatur sind keine Erkenntnisse über den Lokaljournalismus vorhanden, die hier deduktiv als Theoriegrundlage dienen könnten. Deshalb stützen sich die Ergebnisse des vorliegenden Beitrags auf acht leitfadengestützte Experteninterviews, die qualitativ ausgewertet wurden. Die befragen Lokaljournalisten sehen sich als anwaltschaftliche Beobachter, die zwar für die Belange ihres lokalen Kommunikationsraums einstehen, sich aber nicht mit Einzelinteressen gemein machen wollen. Sie wollen das Thema Stromnetzausbau umfassend erklären, einordnen und komplexe Inhalte für ihre Rezipienten verständlich aufbereiten. Die Ergebnisse zeigen, dass Lokaljournalisten eine wichtige Akteursgruppe bei Stromnetzausbauprojekten sind, die es weiter zu untersuchen gilt. Die qualitativen Ergebnisse sind nicht generell verallgemeinerbar und bilden nur das Selbstbild der Befragten ab. Eine ergänzende Medieninhaltsanalyse der Berichterstattung sowie eine Ermittlung des Fremdbildes könnte die wissenschaftliche Diskussion weiter anregen.
This qualitative study focuses on assessing the “future readiness” capacity of three Peruvian Higher Education Institutions under the HEInnovate framework. The main question guiding this research is: To what extent can Peruvian universities be considered entrepreneurial and ready
for tackling the Challenges of the Future? The Challenges of the Future are understood as the challenges generated by concepts such as The Future of Work, The Global Skills Gap, Employability and unexpected and destabilizing risks of the environment, such as COVID-19.
Universities were studied based on 4 research sub-questions: 1) How do Peruvian HEIs rate in Entrepreneurial Capacity according to the HEInnovate framework? 2) What are the factors supporting or preventing Peruvian HEIs to accomplish their entrepreneurial potential? 3) What efforts are Peruvian HEIs making for developing 21st century skills, accomplishing Digital Transformation, and enhancing their students Employability? and 4) What measures could Peruvian HEIs take in order to maximize their entrepreneurial and future-proof potential? The research methodology used was mixed, applying first a quantitative assessment, and then
complementing the results with in-depth interviews. After presenting the conclusions, recommendations for policy action and for university management are given.
Background
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are frequent and serious complications after surgery. We aim to investigate the association between genetic variants in cholinergic candidate genes according to the Kyoto encyclopedia of genes and genomes - pathway: cholinergic neurotransmission with the development of POD or POCD in elderly patients.
Methods
This analysis is part of the European BioCog project (www.biocog.eu), a prospective multicenter observational study with elderly surgical patients. Patients with a Mini-Mental-State-Examination score ≤ 23 points were excluded. POD was assessed up to seven days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method and a patient chart review. POCD was assessed three months after surgery with a neuropsychological test battery. Genotyping was performed on the Illumina Infinium Global Screening Array. Associations with POD and POCD were analyzed using logistic regression analysis, adjusted for age, comorbidities and duration of anesthesia (for POCD analysis additionally for education). Odds ratios (OR) refer to minor allele counts (0, 1, 2).
Results
745 patients could be included in the POD analysis, and 452 in the POCD analysis. The rate of POD within this group was 20.8% (155 patients), and the rate of POCD was 10.2% (46 patients). In a candidate gene approach three genetic variants of the cholinergic genes CHRM2 and CHRM4 were associated with POD (OR [95% confidence interval], rs8191992: 0.61[0.46; 0.80]; rs8191992: 1.60[1.22; 2.09]; rs2067482: 1.64[1.10; 2.44]). No associations were found for POCD.
Conclusions
We found an association between genetic variants of CHRM2 and CHRM4 and POD. Further studies are needed to investigate whether disturbances in acetylcholine release and synaptic plasticity are involved in the development of POD.