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Despite normal neurological bedside and electrodiagnostic, some patients with non-specific neck arm pain (NSNAP) have heightened nerve mechanosensitivity upon neurodynamic testing [1, 2]. It remains however unclear whether this is associated with a minor nerve injury. The aim of this study was to evaluate potential differences in somatosensory function among patients with unilateral NSNAP with and without positive neurodynamic tests and healthy controls.
Quantitative sensory testing was performed in 40 patients with unilateral NSNAP; 23 with positive upper limb neurodynamic tests (ULNTPOS) and 17 with negative neurodynamic tests (ULNTNEG). The protocol comprised thermal and mechanical detection and pain thresholds as well as mechanical pain sensitivity, wind-up ratio and dynamic mechanical allodynia. All parameters were measured in the maximal pain area on the affected side as well as over the corresponding area on the unaffected side. Symptom severity, functional deficits, psychological parameters, quality of life and sleep disturbance were also recorded.
Fifty-seven percent of patients with NSNAP had positive neurodynamic tests despite normal bedside neurological integrity tests and nerve conduction parameters. Clinical profiles did not differ between patient groups. Somatosensory profiling revealed a more pronounced loss of function phenotype in ULNTPOS patients compared to healthy controls. Hyperalgesia (cold, heat and pressure pain) was present bilaterally in both NSNAP group. The ULNTNEG subgroup represented an intermediate phenotype between ULNTPOS patients and healthy controls in both thermal and pressure pain thresholds as well as mechanical detection thresholds.
In conclusion, heightened nerve mechanosensitivity was present in over half of patients with NSNAP. Our data suggest that NSNAP presents as a spectrum with some patients showing signs suggestive of a minor nerve dysfunction.
[1] Elvey RL. Physical evaluation of the peripheral nervous system in disorders of pain and dysfunction. J Hand Ther 1997;10:122-129.
[2] van der Heide B, Bourgoin C, Eils G, Garnevall B, Blackmore M. Test-retest reliability and face validity of a modified neural tissue provocation test in patients with cervicobrachial pain syndrome. J Man Manip Ther 2006;14:30-36.
Knowledge of the small-scale nutrient status of arable land is an important basis for optimizing fertilizer use in crop production. A mobile field laboratory opens up the possibility of carrying out soil sampling and nutrient analysis directly on the field. In addition to the benefits of fast data availability and the avoidance of soil material transport to the laboratory, it provides a future foundation for advanced application options, e.g. a high sampling density, sampling of small sub-fields or dynamic adaptation of the sampling line during field sampling. An innovative key component is the NUTRI-STAT ISFET sensor module. It measures values for the ions "NO3- ”, “H2PO4- " and "K+ " as well as the pH. The ISFET sensor module was specially developed for soil nutrient analysis. The phosphorus measurement was further developed for the project "soil2data". First results from the ISFET sensor module show a measurement signal settling time of significantly less than 100 seconds and a further consistent stable measurement signal. The measurement signal dynamics of approx. 58 mV per factor 10 of concentration change is given for the measured variables pH and K+. For the measured quantities of NO3- and H2PO4- , the measurement signal dynamics are lower.
Soil versus foliar iodine fertilization as a biofortification strategy for field-grown vegetables
(2015)
Iodine (I) biofortification of vegetables by means of soil and foliar applications was investigated in field experiments on a sandy loam soil. Supply of iodine to the soil in trial plots fertilized with potassium iodide (KI) and potassium iodate directly before planting (0, 1.0, 2.5, 7.5, and 15 kg I ha-1) increased the iodine concentration in the edible plant parts. The highest iodine accumulation levels were observed in the first growing season: In butterhead lettuce and kohlrabi the desired iodine content [50–100 μg I (100 g FM)-1] was obtained or exceeded at a fertilizer rate of 7.5 kg IO3--I ha-1 without a significant yield reduction or impairment of the marketable quality. In contrast, supplying KI at the same rate resulted in a much lower iodine enrichment and clearly visible growth impairment. Soil applied iodine was phytoavailable only for a short period of time as indicated by a rapid decline of CaCl2-extractable iodine in the top soil. Consequently, long-term effects of a one-time iodine soil fertilization could not be observed. A comparison between the soil and the foliar fertilization revealed a better performance of iodine applied aerially to butterhead lettuce, which reached the desired iodine accumulation in edible plant parts at a fertilizer rate of 0.5 kg I--I ha-1. In contrast, the iodine content in the tuber of sprayed kohlrabi remained far below the targeted range. The results indicate that a sufficient spreading of iodine applied on the edible plant parts is crucial for the efficiency of the foliar approach and leafy vegetables are the more suitable target crops. The low iodine doses needed as well as the easy and inexpensive application may favor the implementation of foliar sprays as the preferred iodine biofortification strategy in practice.
Spinach is a nitrogen (N)-demanding crop characterized by a shallow root architecture. Especially in the first weeks after sowing, significant N uptake is limited to the uppermost few centimetres of the soil. However, base fertilization is usually based on the soil mineral N (Nmin) concentration in the upper 30 cm. Therefore, the objective of this study was to examine whether the soil sample depth for calculating the base N fertilization can be reduced to the 0-15 cm layer. In seven field trials, conducted during spring, summer and autumn seasons, either a low or high base fertilization dose was applied at sowing. Until top dressing, soil samples were frequently taken in the upper 0-15 and 15-30 cm layers to determine the average Nmin concentration in each layer. Top dressing was applied when the first true leaves had unfurled. With this fertilizer application, the total N supply was aligned between both treatments based on the Nmin concentration in the upper 30 cm of the soil. Aboveground fresh and dry masses were determined after reaching a fresh mass yield of 15-20 t ha‑1 and related to the mean Nmin concentration in the first 3 to 4 weeks of cultivation between sowing and top dressing. It was shown that the Nmin concentration in the upper 0-15 cm of the soil highly reflects the base fertilization rate. By contrast, the Nmin concentration in the 15-30 cm layer remained unaffected. However, the Nmin concentration of both top soil layers can affect fresh and dry mass yield at harvest. Therefore, the entire 0-30 cm soil layer should be considered when calculating the base N fertilization rate in field-grown spinach. Measurements revealed that spinach fresh and dry masses were increased until the N availability of between 54 and 59 kg ha‑1 (0-30 cm) was reached at the seedlings stage, respectively.
The break-up of the Soviet Union in 1991 triggered cropland abandonment on a continental scale, which in turn ledto carbon accumulation on abandoned land across Eurasia. Previous studies have estimated carbon accumulationrates across Russia based on large-scale modelling. Studies that assess carbon sequestration on abandoned land basedon robust field sampling are rare. We investigated soil organic carbon (SOC) stocks using a randomized samplingdesign along a climatic gradient from forest steppe to Sub-Taiga in Western Siberia (Tyumen Province). In total, SOCcontents were sampled on 470 plots across different soil and land-use types. The effect of land use on changes in SOCstock was evaluated, and carbon sequestration rates were calculated for different age stages of abandoned cropland.While land-use type had an effect on carbon accumulation in the topsoil (0–5 cm), no independent land-use effectswere found for deeper SOC stocks. Topsoil carbon stocks of grasslands and forests were significantly higher thanthose of soils managed for crops and under abandoned cropland. SOC increased significantly with time sinceabandonment. The average carbon sequestration rate for soils of abandoned cropland was 0.66 Mg C ha1yr1(1–20 years old, 0–5 cm soil depth), which is at the lower end of published estimates for Russia and Siberia. Therewas a tendency towards SOC saturation on abandoned land as sequestration rates were much higher for recentlyabandoned (1–10 years old, 1.04 Mg C ha1yr1) compared to earlier abandoned crop fields (11–20 years old,0.26 Mg C ha1yr1). Our study confirms the global significance of abandoned cropland in Russia for carbonsequestration. Our findings also suggest that robust regional surveys based on a large number of samples advancemodel-based continent-wide SOC prediction.
This chapter examines the integration of Sustainable Development Goal 5 (SDG 5) into identity-based brand management by focusing on Dove’s brand management as a case study. The Dove “Real Beauty” campaign highlights the potential for brands to address gender equality and female empowerment by aligning with pro-female and feminist principles. A narrative literature review shows how the components of identity-based brand management have been observed in scholarly discussions. Despite mixed responses and criticisms, Dove initiated important conversations around beauty standards and gender equality. The chapter emphasizes the need for authenticity, sensitivity, and continuous improvement in integrating SDG 5 into brand management while acknowledging the potential risks and limitations of consumerist therapy and false hopes. Future research could therefore explore diverse brands, industries, and cultural contexts, as well as the role of intersectionality in identity-based brand management.
Social determinants of health that influence the healthy living process in a vulnerable community
(2016)
Small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia
(2018)
Background:
Chemotherapy-induced Peripheral Neuropathy (CIPN) of large-fibers affects up to 20% of survivors of pediatric acute lymphoblastic leukemia (ALL). We aimed to describe small-fiber toxicity and pain sensitization in this group.
Methods:
In a cross-sectional, bicentric study we assessed 46 survivors of pediatric ALL (Mean age: 5.7 ± 3.5 years at diagnosis, median 2.5 years after therapy; males: 28). Inclusion criteria: ≥6 years of age, ≥3 months after last administration of Vincristine, and cumulative dose of Vincristine 12 mg/m2. We used a reduced version of the Pediatric-modified Total Neuropathy Score (Ped-mTNS) as bedside test and Quantitative Sensory Testing (QST) for assessment of small- and large-fiber neuropathy as well as pain sensitization. We employed Nerve Conduction Studies (NCS) as the most accurate tool for detecting large-fiber neuropathy.
Results:
Fifteen survivors (33%) had abnormal rPed-mTNS values (≥4 points) and 5 survivors (11%) reported pain. In QST, the survivor group showed significant (p < 0.001) inferior large-fiber function and pain sensitization when compared to healthy matched peers. We identified deficits of vibration in 33 (72%) and tactile hypoesthesia in 29 (63%), hyperalgesia to blunt pressure in 19 (41%), increased mechanical pain sensitivity in 12 (26%) and allodynia in 16 (35%) of 46 survivors. Only 7 survivors (15%) had pathologic NCS.
Conclusion:
QST is a sensitive tool that revealed signs of large-fiber neuropathy in two thirds, small-fiber neuropathy and pain sensitization in one third of survivors. Prospective studies using QST in pediatric oncology may help to elucidate the pathophysiology of small-fiber neuropathy and pain sensitization as well as their relevance for quality of survival.
Background
The population-based mammography screening program (MSP) was implemented by the end of 2005 in Germany, and all women between 50 and 69 years are actively invited to a free biennial screening examination. However, despite the expected benefits, the overall participation rates range only between 50 and 55 %. There is also increasing evidence that belonging to a vulnerable population, such as ethnic minorities or low income groups, is associated with a decreased likelihood of participating in screening programs. This study aimed to analyze in more detail the intra-urban variation of MSP uptake at the neighborhood level (i.e. statistical districts) for the city of Dortmund in northwest Germany and to identify demographic and socioeconomic risk factors that contribute to non-response to screening invitations.
Methods
The numbers of participants by statistical district were aggregated over the three periods 2007/2008, 2009/2010, and 2011/2012. Participation rates were calculated as numbers of participants per female resident population averaged over each 2-year period. Bayesian hierarchical spatial models extended with a temporal and spatio-temporal interaction effect were used to analyze the participation rates applying integrated nested Laplace approximations (INLA). The model included explanatory covariates taken from the atlas of social structure of Dortmund.
Results
Generally, participation rates rose for all districts over the time periods. However, participation was persistently lowest in the inner city of Dortmund. Multivariable regression analysis showed that migrant status and long-term unemployment were associated with significant increases of non-attendance in the MSP.
Conclusion
Low income groups and immigrant populations are clustered in the inner city of Dortmund and the observed spatial pattern of persistently low participation in the city center is likely linked to the underlying socioeconomic gradient. This corresponds with the findings of the ecological regression analysis manifesting socioeconomically deprived neighborhoods as risk factors for low attendance in the MSP. Spatio-temporal surveillance of participation in cancer screening programs may be used to identify spatial inequalities in screening uptake and plan spatially focused interventions.
Recent real-time networking developments have enabled ultra reliability, very low latency and high data rates in wired networks. Wireless networking developments have also shown that they can achieve very high data rates with consistency, but they still lack in providing ultra reliability and extremely low latency. Time Sensitive Networking (TSN) developments have brought these capabilities in Industry automation and Automotive industry too. Although TSN is standardized for wired networks for a long time, for wireless networks it will be standardized within the IEEE 802.11be standard for Wi-Fi and 3GPP Release 17 for 5G in the near future. This paper provides an overview of TSN in wired and wireless networks with the aim of comparing different simulators and presenting their offered functionality and shortcomings. These tools can be used to make oneself familiar with TSN algorithms, standards, and for the development and testing of time sensitive networks. Afterwards, the paper discusses open research questions for using TSN over wireless networks.
SimBO is a flexible framework for optimizing discrete event-driven simulations (DES) using sequential optimization algorithms. While specifically designed for Bayesian Optimization (BO) in the context of DES, SimBO can be applied to any black-box problem with other optimization algorithms. The framework consists of four encapsulated components - the black-box problem, the sequential optimization algorithm, a database for experiment configuration and results, and a web-based graphical user interface - that communicate via well-defined interfaces. Each component can be run in different environments, allowing for cooperation between different hardware- and software configurations. In our research context, SimBO’s architecture enabled BO algorithms to be run on a high-performance cluster with GPU support, while the simulation is executed on a local Windows machine using the Simio simulation software. The framework’s flexibility also makes it suitable for evolving from a research-focused tool to a production-ready, cloud-based optimization tool for modern algorithms.
Apps have been attested to empower patients regarding disease self-management through numerous studies. However, it is still unclear what factors determine the perception of patients whether an app is a useful tool for this purpose. A multiple regression model that was informed by the Technology Acceptance Model (TAM 2) was tested based on the answers of 235 app users with Diabetes type 1 or 2. The model accounted for 59.2% of the variance of the perceived degree of self-management. Factors belonging to the relevance-usefulness-quality complex as well as factors reflecting the patient’s self-control were found to be significant in the model. Patient demographics, i.e. age, gender, app experience and type of Diabetes did not play any significant role. In conclusion, this study raises the question whether apps should be designed to strengthen self-management in the sense of self-control (e.g. own measurements, diary) as opposed to guiding and advice giving.
Purpose
The purpose of this paper is to provide a deeper understanding of how transformational leadership relates to followers' innovation implementation behavior, the psychological mechanisms of this relationship, and the role of individual perceptions of climate for initiative.
Design/methodology/approach
Perceptual data were collected from 198 employees in lower and middle management positions of a multinational automotive corporation. Relationships were tested using hierarchical regression analysis.
Findings
Results demonstrate that transformational leadership was strongly related to followers' innovation implementation behavior and that the nature of this relationship was moderated by followers' levels of perceived climate for initiative. Additionally, commitment to change fully mediated the relationship between transformational leadership and followers' innovation implementation behavior.
Research limitations/implications
The paper is based on a cross‐sectional design. A causal interpretation requires studies with experimental or longitudinal designs.
Practical implications
Companies should invest in transformational leadership training and in the selection of supervisors with this leadership style before initiating the implementation of innovations. Enhancing contextual factors, such as a perceived climate for initiative, should be promoted by integrating them into organizations' reward systems.
Originality/value
The paper is one of the first to investigate the relationship between transformational leadership and followers' innovation implementation behavior. It specifies the organizational contexts under which transformational leadership is most likely related to innovation implementation behavior, and those in which such a relationship is unlikely to occur.
Background
Forced migration significantly endangers health. Women face numerous health risks, including sexual violence, lack of contraception, sexually transmitted disease, and adverse perinatal outcomes. Therefore, sexual and reproductive healthcare is a significant aspect of women asylum seekers’ health.
Even when healthcare costs of asylum seekers are covered by the government, there may be strong barriers to healthcare access and specific needs may be addressed inadequately. The study’s objectives were a) to assess the accommodation and healthcare services provided to women asylum seekers in standard and specialised health care, b) to assess the organisation of healthcare provision and how it addresses the sexual and reproductive healthcare needs of women asylum seekers.
Methods
The study utilised a multi-method approach, comprising a less-dominant quantitative component and dominant qualitative component. The quantitative component assessed accommodation conditions for women in eight asylum centres using a survey. The qualitative component assessed healthcare provision on-site, using semi-structured interviews with health and social care professionals (n = 9). Asylum centres were selected to cover a wide range of characteristics. Interview analysis was guided by thematic analysis.
Results
The accommodation in the asylum centres provided gender-separate rooms and sanitary infrastructure. Two models of healthcare were identified, which differed in the services they provided and in their organisation: 1) a standard healthcare model characterised by a lack of coordination between healthcare providers, unavailability of essential services such as interpreters, and fragmented healthcare, and 2) a specialised healthcare model specifically tailored to the needs of asylum-seekers. Its organisation is characterised by a network of closely collaborating health professionals. It provided essential services not present in the standard model. We recommend the specialised healthcare model as a guideline for best practise.
Conclusions
The standard, non-specialised healthcare model used in some regions in Switzerland does not fully meet the healthcare needs of women asylum seekers. Specialised healthcare services used in other regions, which include translation services as well as gender and culturally sensitive care, are better suited to address these needs. More widespread use of this model would contribute significantly toward protecting the sexual and reproductive integrity and health of women asylum seekers.
Background: The painDETECT questionnaire (PD-Q) has been used as a tool to characterize sensory abnormalities in patients with persistent pain. This study investigated whether the self-reported sensory descriptors of patients with painful cervical radiculopathy (CxRAD) and patients with fibromyalgia (FM), as characterized by responses to verbal sensory descriptors from PD-Q (sensitivity to light touch, cold, heat, slight pressure, feeling of numbness in the main area of pain), were associated with the corresponding sensory parameters as demonstrated by quantitative sensory testing (QST).
Methods: Twenty-three patients with CxRAD (eight women, 46.3 ± 9.6 years) and 22 patients with FM (20 women, 46.1 ± 11.5 years) completed the PD-Q. Standardized QST of dynamic mechanical allodynia, cold and heat pain thresholds, pressure pain thresholds, mechanical and vibration detection thresholds, was recorded from the maximal pain area. Comparative QST data from 31 age-matched healthy controls (HCs; 15 women) were obtained.
Results: Patients with CxRAD demonstrated a match between their self-reported descriptors and QST parameters for all sensory parameters except for sensitivity to light touch, and these matches were statistically significant compared with HC data (p ≤ 0.006). The FM group demonstrated discrepancies between the PD-Q and QST sensory phenotypes for all sensory descriptors, indicating that the self-reported sensory descriptors did not consistently match the QST parameters (p = ≤0.017).
Conclusion: Clinicians and researchers should be cautious about relying on PD-Q as a stand-alone screening tool to determine sensory abnormalities in patients with FM.
As allergy towards apples is widespread, the evaluation of various cultivation and postharvest influences on the allergenic potential is of great importance. Therefore, the analysis of the Mal d 1 content was the focus of this study, originally dealing with investigating the influence of a selenium biofortification on apple quality. The Mal d 1 content of apples was in most cases reduced when the fruits were biofortified with selenium. Apple variety and climatic conditions were identified as further influencing factors for the Mal d 1 content of the fruits. The separate analysis of the peel and the fruit flesh showed that the content of Mal d 1 in the fruit flesh was significantly lower in the biofortified samples than in the controls. In conclusion, the results indicate that the selenium biofortification of apples and biochemical mechanism behind can reduce the allergenic potential regarding the content of Mal d 1.
Selecting items for Big Five questionnaires : At what sample size do factorloadings stabilize?
(2014)
Researchers often use exploratory factor analysis (EFA) to develop and refine questionnaires assessing theBig Five personality traits. We use sequential sampling and bootstrapping to determine the number ofparticipants needed to yield stable loading patterns for the Big Five Inventory (BFI) and the InternationalPersonality Item Pool Big Five measure (IPIP). Overall 21,350 participants (BFI = 10,285; IPIP = 11,065)participated. In two studies primary factor loadings are highly variable in smaller samples (n< 500)and some primary loadings are not stable with 10,000 participants. Most studies will not have adequatesample size to yield stable loading patterns for Big Five measures such as the BFI and IPIP. Researchersshould assess and report the variability of loading patterns.
Within the frame of the EU Common Agricultural Policy, most countries subsidise the establishment and maintenance of perennial flower strips on arable land within Agri-Environmental Schemes to provide foraging habitats and refuges for wildlife.
In a replicated field experiment, we studied the effects of different types of seed mixtures on the establishment and maintenance of perennial flower strips on fertile arable land in the federal state of Saxony-Anhalt, Germany over seven years. The seed mixtures were commonly applied within recent Common Agricultural Policy funding periods: (1) a low-diversity cultivar standard seed mixture (CULTIVAR), (2) a high-diversity cultivar and native plant mixture (MIX), and (3) a high-diversity native plant mixture (WILDFLOWER). All plots were mulched every year in March and at the beginning of August.
The low success of CULTIVAR triggered the massive encroachment of spontaneously established perennial grasses. In MIX, too, cultivars have disappeared after the first year. Both wildflower variants were successful in maintaining a high cover of sown perennial native forbs and a high ratio of established sown species, even after seven years. WILDFLOWER always tended to show better values than MIX. Furthermore, spontaneously establishing species began to spread their cover in MIX in the fifth year, with a very strongly increasing tendency, whereas in WILDFLOWER cover of spontaneously immigrating species stayed satisfyingly low.
Using native wildflowers to establish perennial wildflower strips was very effective in maintaining high species diversity within the Agri-Environmental Schemes funding period of five years and beyond. WILDFLOWER was especially successful. On the other hand, CULTIVAR failed completely. On fertile soils in regions with rather low yearly precipitation, mulching twice a year supported the maintenance of perennial wildflower strips.
Reconnection of floodplains to rivers to enhance fluvial dynamics is a favored method of floodplain restoration in Europe. It is believed that the restoration of hydrological conditions of the floodplain facilitates natural dispersal of target species, and hence the reestablishment, of typical plant communities. The aim of our study was to investigate whether floodplain target species could reach restoration sites via hydrochorous dispersal. We analyzed seed inflow from the river and seed dispersal in different sectors of a new watercourse in the Danube floodplain. Seeds were captured using 27 seed traps during three sampling periods of 3 weeks each from summer 2011 to spring 2012. After germination seedlings were identified, we detected a total of almost 39,000 seeds of 176 species, including 80 target species of riparian habitats. We found significant differences between seasons (most seeds in autumn/winter) and between stream sectors. Fewer seeds came in from the Danube (2,800 seeds) than were transported within the floodplain. Several new floodplain target species were detected, which had not been found in the aboveground vegetation or soil seed bank before the start of the restoration. Seeds of nonnative species did not disperse further than approximately 1 km. Our results indicated that hydrochorous seed dispersal from upstream habitats along the new watercourse was important for the establishment of target species and hence for the success of floodplain restoration. Technical water diversion weirs must be traversable for seeds, and small donor sectors upstream might enhance the reestablishment of target vegetation along new sectors downstream.
Purpose
Sedentary behaviour (SED) and low level of physical activity (PA) might be associated with the development or worsening of pain. Still, studies assessing physical behaviours by accelerometry in individuals with orofacial pain are limited. This study aims to assess whether women with temporomandibular disorders (TMD) present different patterns of physical behaviours in days with (DWP) or without pain (DWoP).
Methods
Twenty-nine out of forty-four women (mean age 29.21 sd 7.96) were diagnosed with TMD and monitored over seven days using a thigh-worn accelerometer. DWP was determined when subjects presented pain in one of the craniocervical regions (head, jaw and neck) with intensity of at least 3 in the numerical rating scale. To be considered a DWoP, the individual presented less than 3 points in the three regions. Daily time-use compositions were described in terms of SED in short (<30 min) and long (≥30 min) bouts, light PA (LPA), moderate-to-vigorous PA (MVPA), and time-in-bed. Isometric log-ratios (ilr) were calculated to express the ratio of time-in-bed to time spent awake, SED relative to LPA and MVPA, SED in short relative to long bouts, and LPA relative to MVPA. Differences between DWP and DWoP were examined using MANOVA, followed by univariate post-hoc tests of pairwise differences.
Results
During DWP, women with TMD spent more time in SED in short (239 min) and long bouts (419 min), less time in LPA (245 min), MVPA (68 min), and in bed (468 min) compared with DWoP (235, 378, 263, 70 and 493 min, respectively). The MANOVA showed that all sets of ilrs did not differ statistically (ηp2 = 0.19, p = 0.25). Still, the post-hoc tests showed a trend that time spent SED relative to LPA and MVPA was larger in DWP than in DWoP (Cohen’s d = 0.36, p = 0.05).
Conclusions
Women with TMD did not show different patterns of physical behaviours in DWP or DWoP. However, there is a trend of more sedentary behaviour and less physical activity in DWP compared to DWoP. Future studies should consider other pain intensity cut-offs, isolated pain locations, and larger sample sizes to confirm these results.
Scientific Entrepreneurship: Raising A wareness of Entrepreneurship - Strategies ans Experiences
(2011)
In a protein reduction feeding trial (Study 1) on a commercial broiler farm in northern Germany, it was attempted to be shown that research results from station tests on protein reduction can be transferred to agricultural practice. In a second study, the limits of the N reduction were tested in a research facility. In Study 1, commercial standard feeds were fed to the control group (variant 1:210,000 animals; n = 5 barns). In the test group (variant 2:210,000 animals; n = 5 barns), the weighted mean crude protein (CP) content was moderately reduced by 0.3%. The nitrogen reduction in the feed did not affect performance (feed intake (FA), daily gain (DG), feed conversion (FCR)), but nitrogen conversion rate increased from approx. 61% to approx. 63%. The solid litter weight was reduced by 12% and nitrogen excretion by 9% (p < 0.05). Significantly healthier footpads were due to lower water intake (−4%; p < 0.05) and a numerically drier bedding. In Study 2, responses of treatments (1250 broiler per variant; n = 5) showed that sharper N-lowering (−1.5% CP; weighted average) did not impair performance either, but N-conversion improved and N-excretions decreased significantly. Converted to a protein reduction of one percentage point, the N excretions were able to be reduced by 22% in Study 1 and 18% in Study 2. Feeding trials in the commercial sector, such as the present Study 1, should convince feed mills and farmers to allow the latest scientific results to be used directly and comprehensively in commercial ration design.
After foundation of the Wadden Sea National Park, grazing and artificial drainage was ceased or reduced on large areas of the salt marshes at the Schleswig-Holstein mainland coast (Northern Germany). The effect of grazing cessation versus intensive and moderate grazing on vegetation diversity was studied on small (plant species richness on plots between 0.01 and 100 m2) and large scale (vegetation type richness per hectare) over 18 to 20 years by analysing data from long-term monitoring programs. Plant species richness and vegetation type richness increased strongly over time in all management regimes, because grazing-sensitive species increased first in ungrazed marshes and later dispersed to and established in intensively grazed marshes. Dominance of the tall, late-successional grass Elymus athericus on 7% to 52% of all moderately and ungrazed (primarily high marsh) plots led to a decrease in species richness. After 18 to 20 years, species richness was highest in moderately and intensively grazed high marshes. Differences were significant only on small plots of up to 4 m2. On the large scale, vegetation type richness in the low marsh was higher without grazing, while no differences were found in the high marsh. Our results indicate that grazing effects differ between spatial scales and that different spatial scales have to be considered for monitoring and evaluation of vegetation diversity in salt marshes. To conserve vegetation diversity on all scales, a large-scale mosaic of different management regimes should be maintained.
Niche-based species distribution models (SDMs) play a central role in studying species response to environmental change. Effective management and conservation plans for freshwater ecosystems require SDMs that accommodate hierarchical catchment ordering and provide clarity on the performance of such models across multiple scales. The scale-dependence components considered here are: (a) environment spatial structure, represented by hierarchical catchment ordering following the Strahler system; (b) analysis grain, that included 1st to 5th order catchments; and (c) response grain, the grain at which species respond most, represented by local and upstream catchment area effects. We used fish occurrence data from the Danube River Basin and various factors representing climate, land cover and anthropogenic pressures. Our results indicate that the choice of response grain – local vs. upstream area effects – and the choice of analysis grain, only marginally influence the performance of SDMs. Upstream effects tend to better predict fish distributions than corresponding local effects for anthropogenic and land cover factors, in particular for species sensitive to pollution. Key predictors and their relative importance are scale and species dependent. Consequently, choosing proper species dependent spatial scales and factors is imperative for effective river rehabilitation measures.
Niche-based species distribution models (SDMs) have become an essential tool in conservation and restoration planning. Given the current threats to freshwater biodiversity, it is of fundamental importance to address scale effects on the performance of niche-based SDMs of freshwater species’ distributions. The scale effects are addressed here in the context of hierarchical catchment ordering, considered as counterpart to coarsening grain-size by increasing grid-cell size. We combine fish occurrence data from the Danube River Basin, the hierarchical catchment ordering and multiple environmental factors representing topographic, climatic and anthropogenic effects to model fish occurrence probability across multiple scales. We focus on 1st to 5th order catchments. The spatial scale (hierarchical catchment order) only marginally influences the mean performance of SDMs, however the uncertainty of the estimates increases with scale. Key predictors and their relative importance are scale and species dependent. Our findings have useful implications for choosing proper species dependent spatial scales for river rehabilitation measures, and for conservation planning in areas where fine grain species data are unavailable.
Despite similar policy goals, the adoption of eHealth practices took different paths in Austria (AT), Switzerland (CH), and Germany (GER). We seek to provide a rigorous analysis of the current state of hospitals by focusing on three key eHealth areas: electronic patient records (EPR), health information exchange (HIE), electronic patient communication. For validation and in order to gain better contextual insight we applied a mixed method approach by combining survey results from clinical directors with qualitative interview data from eHealth experts of all three countries. Across countries, EPR adoption rates were reported highest (AT: 52%, CH: 78%, GER: 50%), HIE-rates were partly lower (AT: 52%, CH: 14%, GER: 17%), and electronic patient communication was reported lowest overall (AT: 17%, CH: 8%, GER: 19%). Amongst others, results indicate patient awareness about eHealth to be equally weak across countries, which thus may be an important focal point of future policy initiatives.
In modern times, closed-loop control systems (CLCSs) play a prominent role in a wide application range, from production machinery via automated vehicles to robots. CLCSs actively manipulate the actual values of a process to match predetermined setpoints, typically in real time and with remarkable precision. However, the development, modeling, tuning, and optimization of CLCSs barely exploit the potential of artificial intelligence (AI). This paper explores novel opportunities and research directions in CLCS engineering, presenting potential designs and methodologies incorporating AI. Combining these opportunities and directions makes it evident that employing AI in developing and implementing CLCSs is indeed feasible. Integrating AI into CLCS development or AI directly within CLCSs can lead to a significant improvement in stakeholder confidence. Integrating AI in CLCSs raises the question: How can AI in CLCSs be trusted so that its promising capabilities can be used safely? One does not trust AI in CLCSs due to its unknowable nature caused by its extensive set of parameters that defy complete testing. Consequently, developers working on AI-based CLCSs must be able to rate the impact of the trainable parameters on the system accurately. By following this path, this paper highlights two key aspects as essential research directions towards safe AI-based CLCSs: (I) the identification and elimination of unproductive layers in artificial neural networks (ANNs) for reducing the number of trainable parameters without influencing the overall outcome, and (II) the utilization of the solution space of an ANN to define the safety-critical scenarios of an AI-based CLCS.
Green roofs can mitigate negative environmental effects of urban densifcation to some extent, but they are often covered by species-poor Sedum mixtures with a low value for biodiversity. By combining a habitat template and a seedprovenance approach, we review the suitability of plant species from regionally occurring dry sandy grasslands (Koelerio-Corynophoretea) for extensive roof greening in northwestern Germany. Since 2015, we have studied the effects of species introduction on vegetation dynamics on experimental mini-roofs. Treatments included sowing seeds of regional native origin in two densities (1 g and 2 g/m2) and the transfer of raked material from an ancient dry grassland area classifed as Natura 2000 site. The applied raked material contained diaspores of 27 vascular plant species (including seven threatened species) and vegetative fragments of grasslandspecifc mosses and lichens. Since 2018, we have tested more species-rich seed mixtures in a large-scale experiment on a roof of 500 m2 with different engineered green-roof substrates and layering. In 2019, a green roof of 10,200 m2 was established in cooperation with a local enterprise to support regional native biodiversity.
In this chapter, we summarise the most important results of our studies and discuss how to support regional native biodiversity on green roofs.
Management of agricultural processes is often troubled by disconnections and data transfer failures. Limited cellular network coverage may prevent information exchange between mobile process participants.
The research projects KOMOBAR and ISOCom designed, implemented und field-tested a delay tolerant platform for robust communication in rural areas and challenging environments. An adaptable combination of infrastructure-based cellular networks and infrastructure-free multihop ad hoc communication (WLAN) leads to a variety of new communication opportunities. Temporal storage and forwarding of data on mobile farm machinery as well as dynamic platform configurations during process runtime strongly enhance reliability and robustness of data transfers.
We describe an automated approach, to easily track patients regaining their walking ability while recovering from neurological diseases like e.g. stroke. Based on captured gait data and objective measures derived out of it the rehabilitation process can be optimized and thus steered. In order to apply such system in clinical practice two key requirements have to be fulfilled: (i) the system needs to be applicable in terms of ease of use and performance; (ii) the derived measures need to be accurate.
Rationale:
Dance as an intense kind of performance is associated with high loads on the musculoskeletal system. In particular, the lower limb is exposed to these high loads, which is reported by a high prevalence. Most dancers are affected by injuries during their careers, most in the lower limb. Typical risk factors for dancers include the compensatory turnout, hypermobility, and core stability. The correlation between these factors and lower limb injuries is not fully understood.
Purpose:
The aim of this study was to evaluate the correlation between lower limb injuries and the risk factors compensated turnout, hypermobility and core stability. Based on these results, hypotheses can be generated for further studies.
Methods:
This explorative pilot study was conducted at Osnabrück University of Applied Sciences. All eligible participants were scheduled for a single research appointment if they fulfilled the inclusion criteria of dance experience (ballet, modern, contemporary or jazz) at least one year with dance lessons of at least 5 hours per week. Parameters for the correlation analysis were (1) core stability, measured by the motor control tests battery proposed by Luomajoki, (2) hypermobility, measured by the Beighton Score (3) compensated turnout, measured by the difference between functional turnout and external rotation of both hips, (4) dance hours per week, (5) dance experience in years, (6) professional dance experience in years and (7) dance style (ballet, modern, contemporary, jazz). These parameters were correlated with the numbers of lower limb injuries. Significance level was set at 90% because of the explorative character of the study with the purpose to generate hypotheses.
Results:
Sixteen female dancers with different levels of dance experience (mean 11.3 years) and dance lessons per week (mean 17.6 hours) fulfilled the inclusion criteria and participated in this study. Significant correlations with the numbers of lower limb injuries were found at core stability (rs=0.489, p=0.034, medium effect), dance hours per week (rs=0.459, p=0.048, medium effect) and professional dance experience in years (rs=0.396, p=0.093, medium effect). Two dance styles (modern dance: rs=0.388, p=0.101 and contemporary dance: rs=0.385, p=0.104) were close to the significance level.
Conclusions:
These results show correlations between core stability, dance hours per week, professional dance experience in years and lower limb injuries in dancers.
Due to the limitations of a small and heterogeneous sample size as well as the medium effects, these results should be interpreted with caution, but may provide a basis for further research to this topic in the field of dance research and can be helpful in generating research hypotheses.
Semi-solid metal alloys, as used in thixoforming, have a special microstructure of globular grains suspended in a liquid metal matrix. The material under investigation is a tin–lead alloy (Sn–15% Pb) which exhibits a similar microstructure as aluminum alloys. The experiments were performed with concentric cylinder rheometers. Initially, the liquid alloy is cooled down to the semi-solid range under constant shearing and then kept under isothermal conditions for further experimentation. The microstructure is characterized in dependence of the shearing time. The rheological techniques consisted of step change of shear rate and shear stress ramp experiments for different solid fractions (40–50%). Based on the experimental data a single phase model has been derived, where the semi-solid alloy is regarded as a homogeneous material with thixotropic properties and the microstructure is characterized by a structural parameter. The model consists of two parts: the equation of state, including a finite yield stress, and a rate equation for the structural parameter. The model equations are employed into numerical software and used for the simulation of a characteristic thixocasting process. The results are compared to real experiments.
Restricted Versus Unrestricted Search Space : Experience from Mining a Large Japanese Database
(2015)
The aim of this study was to investigate whether standard Big Data mining methods lead to clinically useful results. An association analysis was performed using the apriori algorithm to discover associations among co-morbidities of diabetes patients. Selected data were further analyzed by using k-means clustering with age, long-term blood sugar and cholesterol values. The association analysis led to a multitude of trivial rules. Cluster analysis detected clusters of well and badly managed diabetes patients both belonging to different age groups. The study suggests the usage of cluster analysis on a restricted space to come to meaningful results.
Species dispersal, establishment, and assembly are crucial stages of the life history of plants, and clear understanding ofthe governing forces and rules that shape species composition in a particular community is vital for successful ecologicalrestoration. In this article, we focus on five aspects of seed dispersal and plant establishment, which should be consideredduring habitat restoration actions. In the first two sections, we discuss the success of spontaneous dispersal and establishmenton restoration based on either spatial dispersal or local seed banks. In the third section, we assess the possibilities ofspecies introduction and assisted dispersal. In the fourth section, we introduce some possibilities for the improvement ofestablishment success of spontaneously dispersed or introduced species. Finally, we highlight issues influencing long-termpersistence and sustainability of restored habitats, related to the alteration of management type and intensity, climate change,and spread of non-native species. With the present article, we introduce the special issue entitled “Seed dispersal and soil seedbanks – promising sources for ecological restoration” containing 15 papers by 62 authors from 10 countries arranged in theabovementioned five topics.
Response of petunia to wood fibre amended peat substrate under ebb-and-flow irrigation (Abstract)
(2024)
The Internet of Things (IoT) is the enabler for new innovations in several domains. It allows the connection of digital services with physical entities in the real world. These entities are devices of different categories and sizes range from large machinery to tiny sensors. In the latter case, devices are typically characterized by limited resources in terms of computational power, available memory and sometimes limited power supply. As a consequence, the use of security algorithms requires of them to work within the limited resources. This means to find a suitable implementation and configuration for a security algorithm, that performs properly on the device, which may become a challenging task. On the other side, there is the desire to protect valuable assets as strong as possible. Usually, security goals are recorded in security policies, but they do not consider resource availability on the involved device and its power consumption while executing security algorithms. This paper presents an IoT security configuration tool that helps the designer of an IoT environment to experiment with the trade-off between maximizing security and extending the lifetime of a resource constrained IoT device. The tool is controlled with high-level description of security goals in the form of policies. It allows the designer to validate various (security) configurations for a single IoT device up to a large sensor network.
Process modeling languages help to define and execute processes and workflows. The Business Process Model and Notation (BPMN) 2.0 is used for business processes in commercial areas such as banks, shops, production and supply industry. Due to its flexible notation, BPMN is increasingly being used in non-traditional business process domains like Internet of Things (IoT) and agriculture. However, BPMN does not fit well to scenarios taking place in environments featuring limited, delayed, intermittent or broken connectivity. Communication just exists for BPMN - characteristics of message transfers, their priorities and connectivity parameters are not part of the model. No backup mechanism for communication issues exists, resulting in error-prone and failing processes. This paper introduces resilient BPMN (rBPMN), a valid BPMN extension for process modeling in unreliable communication environments. The meta model addition of opportunistic message flows with Quality of Service (QoS) parameters and connectivity characteristics allows to verify and enhance process robustness at design time. Modeling of explicit or implicit, decision-based alternatives ensures optimal process operation even when connectivity issues occur. In case of no connectivity, locally moved functionality guarantees stable process operation. Evaluation using an agricultural slurry application showed significant robustness enhancements and prevented process failures due to communication issues.
Health IT systems are employed to support continuity of care via information continuity, while management continuity is often neglected. This study aims at investigating issues of management continuity when developing a collaborative decision support system for chronic wounds. Thirty-three experts from a variety of professions and disciplines discussed problems and possible solutions in four workshops. The following topics emerged from the discussion: existing networks involving payers, responsibilities as well as good discharge management. These topics clearly address management continuity and are also relevant for the scenario of inter-professional wound care across different settings.
Despite the wealth of literature on requirements engineering, little is known about engineering very generic, innovative and emerging requirements, such as those for cross-sectional information chains. The IKM health project aims at building information chain reference models for the care of patients with chronic wounds, cancer-related pain and back pain. Our question therefore was how to appropriately capture information and process requirements that are both generally applicable and practically useful. To this end, we started with recommendations from clinical guidelines and put them up for discussion in Delphi surveys and expert interviews. Despite the heterogeneity we encountered in all three methods, it was possible to obtain requirements suitable for building reference models. We evaluated three modelling languages and then chose to write the models in UML (class and activity diagrams). On the basis of the current project results, the pros and cons of our approach are discussed.
Recent theoretical models suggest that repetitive negative thinking might be a key mechanism explaining the negative effects of maternal psychopathology on mother–infant relations. While an emerging body of research largely supports this idea, the relative importance of differences in the trajectory of repetitive negative thinking during and after pregnancy for mother–infant bonding as well as maternal depressive symptoms is currently unknown. Therefore, we investigated associations between the course of maternal repetitive negative thinking during pregnancy and after birth and mother–infant-bonding and maternal depressive symptoms in a longitudinal study. The overall level of repetitive negative thinking was a significant predictor of mother–infant bonding, maternal anxiety and rejection in dealing with her infant four months after birth. Furthermore, differences in the trajectory of repetitive negative thinking predicted bonding, but not anxiety or rejection. The overall levels of repetitive negative thinking as well as the differences in the trajectory of repetitive negative thinking were significant predictors of maternal depressive symptoms. These findings indicate that changes of repetitive negative thinking during and after pregnancy can increase the risk of postpartum depressive symptoms.
Within the consortium “Experimentation Field Agro-Nordwest”, a practical concept for knowledge and technology transfer of digital competence in agriculture was created. For this purpose, the web-based e-learning system “SensX” was set up, consisting of videos, presentations and instructions. In addition, the classical e-learning concept was extended by data sets, student experiments and sensor data of plants acquired by a remote phenotyping robot. This resulted in a massive open online course (MOOC), which was tested with agricultural and biotechnology students in higher education at the University of Applied Sciences Osnabrück over two years. The evaluation process of “SensX” included an empirical survey, qualitative interviews of the participating students by an external institution and an evaluation of the concept by the lecturers.
Relationship of QST measures between low back and leg sites in people with radicular leg pain
(2019)
Background and Aims
Clinicians and researchers often rely on altered neurological integrity tests in the leg to identify radicular pain, however neurological integrity is often not tested in the low back region even in the presence of pain in this region. There have been suggestions that the low back pain itself could be neuropathic in nature in some patients (Baron et al., 2016). This study aims to explore the relationship between quantitative sensory testing (QST) measures in the leg and low back in participants with radicular leg pain to consider if sensory testing should be performed in both areas in clinical practice.
Methods
13 participants (mean age 48.2 SD 13.8, gender (female) 8) with radicular leg pain were recruited from National Health Service spinal clinics in the UK. After assessment with the clinician, a full QST profile was taken from each participant’s affected leg and low back. Z scores were calculated using data from age matched healthy controls. Correlations using Pearson’s if the data was normally distributed or Kendall’s Tau-b if not, were undertaken between QST scores of the low back and leg. Paired t tests or Mann Whitney tests were performed to assess differences in QST scores between the leg and low back regions.
Results
There were no significant correlations (P>0.05) in any of the QST measures between the leg and the low back regions. However, only vibration detection threshold measures showed statistically significant differences between the leg and low back (p<0.001), with the low back region showing greater loss of function (mean -2.84) than the leg (mean -0.61).
Conclusions
Significantly lower vibration thresholds were found in the back compared to the leg. This may suggest some alteration in posterior primary ramus large diameter afferent nerve function, and indicate that the low back pain itself may indeed have a neuropathic component. Our findings suggest that sensory testing of the lumbar spine may be advisable in this group of individuals. The small sample size means that these results must be taken with some caution, however these results warrant further investigation in people with radicular leg pain.
Notable parts of the population in Europe suffer from allergies towards apples. To address this health problem, the analysis of the interactions of relevant allergens with other substances such as phenolic compounds is of particular importance. The aim of this study was to evaluate the correlations between the total phenolic content (TPC), polyphenol oxidase (PPO) activity, antioxidant activity (AOA), and the phenolic compound profile and the content of the allergenic protein Mal d 1 in six apple cultivars. It was found that the PPO activity and the content of individual phenolic compounds had an influence on the Mal d 1 content. With regard to the important constituents, flavan-3-ols and phenolic acids, it was found that apples with a higher content of chlorogenic acid and a low content of procyanidin trimers and/or epicatechin had a lower allergenic potential. This is probably based on the reaction of phenolic compounds (when oxidized by the endogenous PPO) with proteins, thus being able to change the conformation of the (allergenic) proteins, which further corresponds to a loss of antibody recognition. When apples were additionally biofortified with selenium, the composition of the apples, with regard to TPC, phenolic profile, AOA, and PPO, was significantly affected. Consequently, this innovative agronomic practice seems to be promising for reducing the allergenic potential of apples.
The energy transition can be mapped on four levels. While industry and the state should act on the national and international level, most of the energy transition is taking place at the regional and municipal levels. Here the small-scale and decentralized nature of the new energy world is reflected, where customized individual solutions are created.
Rationale:
Performing artists are exposed to high strains during their performance. These strains are similar to the ones of professional athletes, but in contrast to athletes there is a comprehensive undersupply of care regarding preventive and rehabilitative therapy offers.
Purpose:
The purpose of RefLabPerform is to develop a reference laboratory for the assessment of neuromusculoskeletal disorders using physiotherapeutic assessment methods in combination with biomechanical motion analysis. This includes the automatized integration of the physiotherapeutic assessments with the technical biomechanical analysis for an individual treatment recommendation with decentralized health care recommendations for a home-based therapy based on evidence-based prevention and rehabilitation strategies.
Methods:
Several work packages are processed systematically, whereby according to the requirements in the course of the project an overlapping of work packages occurs. First, the component planning of the innovative reference laboratory structure is carried out, on which the clinical and technical development of the reference laboratory is based. The next steps are the development of individual clinical assessment protocols, prevention and rehabilitation strategies as well as the setup of the laboratory and the development of technical routines. Parallel to this, various analysis tools are being developed for biomechanical data as well as for physiotherapeutic diagnostics and merged at the end of this work package for individual results for different groups of performing artists. Overlapping with the previous work packages, the reference laboratory will be tested for application and manageability. Clinical and technical data are brought together and checked by means of individual case trials on various groups of artists. In terms of an agile software development process, the results flow back into the previous work packages in order to optimize them and then test them again.
Results:
At the end of the project a functional and proven reference laboratory for the comprehensive analysis of performing artists will be developed.
Conclusions:
This reference laboratory is specialized to the diagnosis and treatment of playing- and performance-related dysfunctions with a focus on clinical findings and biomechanical movement analysis.
Educational Objectives:
At the end of the presentation, the participants will be able to…
1. describe the innovative content of the project RefLabPerform
2. understand the advantages of merged analysis strategies by physiotherapeutic and biomechanical examinations
3. understand the complex interdisciplinary process to develop a reference laboratory for performing artists
Rationale:
Performing artists are exposed to high strains during their performance. These strains are similar to the ones of professional athletes, but in contrast to athletes there is a comprehensive undersupply of care regarding preventive and rehabilitative therapy offers.
Purpose:
The purpose of RefLabPerform is to develop a reference laboratory for the assessment of neuromusculoskeletal disorders using physiotherapeutic assessment methods in combination with biomechanical motion analysis. This includes the automatized integration of the physiotherapeutic assessments with the technical biomechanical analysis for an individual treatment recommendation with decentralized health care recommendations for a home-based therapy based on evidence-based prevention and rehabilitation strategies.
Methods:
Several work packages are processed systematically, whereby according to the requirements in the course of the project an overlapping of work packages occurs. First, the component planning of the innovative reference laboratory structure is carried out, on which the clinical and technical development of the reference laboratory is based. The next steps are the development of individual clinical assessment protocols, prevention and rehabilitation strategies as well as the setup of the laboratory and the development of technical routines. Parallel to this, various analysis tools are being developed for biomechanical data as well as for physiotherapeutic diagnostics and merged at the end of this work package for individual results for different groups of performing artists. Overlapping with the previous work packages, the reference laboratory will be tested for application and manageability. Clinical and technical data are brought together and checked by means of individual case trials on various groups of artists. In terms of an agile software development process, the results flow back into the previous work packages in order to optimize them and then test them again.
Results:
At the end of the project a functional and proven reference laboratory for the comprehensive analysis of performing artists will be developed.
Conclusions:
This reference laboratory is specialized to the diagnosis and treatment of playing- and performance-related dysfunctions with a focus on clinical findings and biomechanical movement analysis.
Educational Objectives:
At the end of the presentation, the participants will be able to…
1. describe the innovative content of the project RefLabPerform
2. understand the advantages of merged analysis strategies by physiotherapeutic and biomechanical examinations
3. understand the complex interdisciplinary process to develop a reference laboratory for performing artists