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Chitin is an abundant waste product from shrimp and mushroom industries and as such, an appropriate secondary feedstock for biotechnological processes. However, chitin is a crystalline substrate embedded in complex biological matrices, and, therefore, difficult to utilize, requiring an equally complex chitinolytic machinery. Following a bottom-up approach, we here describe the step-wise development of a mutualistic, non-competitive consortium in which a lysine-auxotrophic Escherichia coli substrate converter cleaves the chitin monomer N-acetylglucosamine (GlcNAc) into glucosamine (GlcN) and acetate, but uses only acetate while leaving GlcN for growth of the lysine-secreting Corynebacterium glutamicum producer strain. We first engineered the substrate converter strain for growth on acetate but not GlcN, and the producer strain for growth on GlcN but not acetate. Growth of the two strains in co-culture in the presence of a mixture of GlcN and acetate was stabilized through lysine cross-feeding. Addition of recombinant chitinase to cleave chitin into GlcNAc2, chitin deacetylase to convert GlcNAc2 into GlcN2 and acetate, and glucosaminidase to cleave GlcN2 into GlcN supported growth of the two strains in co-culture in the presence of colloidal chitin as sole carbon source. Substrate converter strains secreting a chitinase or a β-1,4-glucosaminidase degraded chitin to GlcNAc2 or GlcN2 to GlcN, respectively, but required glucose for growth. In contrast, by cleaving GlcNAc into GlcN and acetate, a chitin deacetylase-expressing substrate converter enabled growth of the producer strain in co-culture with GlcNAc as sole carbon source, providing proof-of-principle for a fully integrated co-culture for the biotechnological utilization of chitin.
A comparison study on modeling of clustered and overdispersed count data for multiple comparisons
(2021)
Data collected in various scientific fields are count data. One way to analyze such data is to compare the individual levels of the factor treatment using multiple comparisons. However, the measured individuals are often clustered – e.g. according to litter or rearing. This must be considered when estimating the parameters by a repeated measurement model. In addition, ignoring the overdispersion to which count data is prone leads to an increase of the type one error rate. We carry out simulation studies using several different data settings and compare different multiple contrast tests with parameter estimates from generalized estimation equations and generalized linear mixed models in order to observe coverage and rejection probabilities. We generate overdispersed, clustered count data in small samples as can be observed in many biological settings. We have found that the generalized estimation equations outperform generalized linear mixed models if the variance-sandwich estimator is correctly specified. Furthermore, generalized linear mixed models show problems with the convergence rate under certain data settings, but there are model implementations with lower implications exists. Finally, we use an example of genetic data to demonstrate the application of the multiple contrast test and the problems of ignoring strong overdispersion.
Urban greenspace has gained considerable attention during the last decades because of its relevance to wildlife conservation, human welfare, and climate change adaptation. Biodiversity loss and ecosystem degradation worldwide require the formation of new concepts of ecological restoration and rehabilitation aimed at improving ecosystem functions, services, and biodiversity conservation in cities. Although relict sites of natural and semi-natural ecosystems can be found in urban areas, environmental conditions and species composition of most urban ecosystems are highly modified, inducing the development of novel and hybrid ecosystems. A consequence of this ecological novelty is the lack of (semi-) natural reference systems available for defining restoration targets and assessing restoration success in urban areas. This hampers the implementation of ecological restoration in cities. In consideration of these challenges, we present a new conceptual framework that provides guidance and support for urban ecological restoration and rehabilitation by formulating restoration targets for different levels of ecological novelty (i.e., historic, hybrid, and novel ecosystems). To facilitate the restoration and rehabilitation of novel urban ecosystems, we recommend using established species-rich and well-functioning urban ecosystems as reference. Such urban reference systems are likely to be present in many cities. Highlighting their value in comparison to degraded ecosystems can stimulate and guide restoration initiatives. As urban restoration approaches must consider local history and site conditions, as well as citizens’ needs, it may also be advisable to focus the restoration of strongly altered urban ecosystems on selected ecosystem functions, services and/or biodiversity values. Ecosystem restoration and rehabilitation in cities can be either relatively inexpensive or costly, but even expensive measures can pay off when they effectively improve ecosystem services such as climate change mitigation or recreation. Successful re‐shaping and re-thinking of urban greenspace by involving citizens and other stakeholders will help to make our cities more sustainable in the future.
Currently, the treatment of musicians is an interprofessional approach. Playing-related health complaints may impact the performance of a musician. In Germany, a medical consulting hour for musicians exists, but those for athletes in sports medicine are not so common. The diagnosing and treatment procedure within the physiotherapy consultation for musicians follows a specific concept-b and requires knowledge of instruments and musician-specific complaints. Based on the consulting hour in a clinic in Osnabrueck, 614 case reports were part of this sample, of which 558 data sets were complete. The focus of the analysis is the instrument and the primary complaint. Also, the type of therapy is characterized, and the amount is calculated. Primary complaints of musicians, in general, are found most frequently in the spine and upper extremity. Musician complaints are different between instruments. Instrumentalists have a significantly higher chance to suffer from a primary complaint in the area of the upper extremity. Furthermore, the groups without an instrument (e.g., singing or dancing) are developing complaints in the anatomical area which they primarily use. Therefore, these types of therapy were used: physiotherapy, manual therapy, and osteopathy with an average of 5.9 treatment units. This study underpinned the importance of musician-specific physiotherapy as a profession to treat musicians. Also, an interdisciplinary approach is necessary to treat all aspects of complaints.
Transport operations are climate sensitive. Despite this, scientific literature and corporate practice present little evidence on how corporate actors use climate adaptation measures to prepare their transport operations for climate change. This paper explores two research questions: How can the acceptance among corporate decision-makers towards climate adaptation measures for their transport operations be explained? Based on the Theory of Planned Behavior and the Diffusion of Innovations we develop a theoretical framework for dealing with climate adaptation measures for transport operations (step 1). We support the use of this framework through a literature review (1989–2020) (step 2) and semi-structured interviews with German companies that have implemented best practice measures (step 3). The results show that the handling of climate adaptation measures for transport operations can be described in three acceptance phases: acceptance of attitude, action, and use. We conclude that these phases determine the approaches required for promoting climate change adaptation.
The increased consumption of reduced-fat or non-fat products leads to a reduced intake of fat-soluble bioactive substances, such as fat-soluble vitamins. Due to their natural role as transport systems for hydrophobic substances, casein micelles (CM) might depict a viable system. The structure of CM is characterized by a lipophilic core stabilized by an electric double layer-like structure. Modification allows accessibility of the core and, therefore, the inclusion of fat-soluble bioactive substances. Well-known modifications are pH reduction and use of rennet enzyme. A completely new procedure to modify CM structure is offered by pulsed electrical fields (PEF). The principle behind PEF is called electroporation and affects the electric double layer of CM so that it is interrupted. In this way, lipophilic substances can be incorporated into CM. In this work, we evaluated integration of β-carotene into native CM by an industry-compatible process to overcome disadvantages associated with the use of Na-caseinate and avoid great technical effort, e.g., due to treatment with high hydrostatic pressure. Our research has shown that PEF can be used for disintegration of CM and that significant amounts of β-carotene can be incorporated in CM. Furthermore, after disintegration using PEF, a combination of another PEF and thermal treatment was applied to restructure CM and trap significant amounts of β-carotene, permanently, ending up with an encapsulation efficiency of 78%.
Akzeptanz für Algorithmen
(2021)
Chronic illness can have a profound impact on couples’ relationships. In dealing with relational changes, new constructions and forms of relationships may arise. In the context of a larger grounded theory study on relational processes and practices in couples faced with chronic illness, this article focuses on concurrent relationships as an alternative form of relationship construction which embodies an additional relationship existing parallel to that of the couple confronted with chronic illness. Based on qualitative interviews with a subsample of five persons within the larger study, conditions for the development and characteristics of concurrent relationships are presented. From an individual and shared life questioned by chronic illness, concurrent relationships are formed in the attempt to be able to live on together in a new partner relationship and a continued care relationship. This can lead to new constructions of relationships, family life, and social relations in everyday life.
Background:
Contact tracing apps are potentially useful tools for supporting national COVID-19 containment strategies. Various national apps with different technical design features have been commissioned and issued by governments worldwide.
Objective:
Our goal was to develop and propose an item set that was suitable for describing and monitoring nationally issued COVID-19 contact tracing apps. This item set could provide a framework for describing the key technical features of such apps and monitoring their use based on widely available information.
Methods:
We used an open-source intelligence approach (OSINT) to access a multitude of publicly available sources and collect data and information regarding the development and use of contact tracing apps in different countries over several months (from June 2020 to January 2021). The collected documents were then iteratively analyzed via content analysis methods. During this process, an initial set of subject areas were refined into categories for evaluation (ie, coherent topics), which were then examined for individual features. These features were paraphrased as items in the form of questions and applied to information materials from a sample of countries (ie, Brazil, China, Finland, France, Germany, Italy, Singapore, South Korea, Spain, and the United Kingdom [England and Wales]). This sample was purposefully selected; our intention was to include the apps of different countries from around the world and to propose a valid item set that can be relatively easily applied by using an OSINT approach.
Results:
Our OSINT approach and subsequent analysis of the collected documents resulted in the definition of the following five main categories and associated subcategories: (1) background information (open-source code, public information, and collaborators); (2) purpose and workflow (secondary data use and warning process design); (3) technical information (protocol, tracing technology, exposure notification system, and interoperability); (4) privacy protection (the entity of trust and anonymity); and (5) availability and use (release date and the number of downloads). Based on this structure, a set of items that constituted the evaluation framework were specified. The application of these items to the 10 selected countries revealed differences, especially with regard to the centralization of the entity of trust and the overall transparency of the apps’ technical makeup.
Conclusions:
We provide a set of criteria for monitoring and evaluating COVID-19 tracing apps that can be easily applied to publicly issued information. The application of these criteria might help governments to identify design features that promote the successful, widespread adoption of COVID-19 tracing apps among target populations and across national boundaries.
Are natural floods accelerators for streambank vegetationdevelopment in floodplain restoration?
(2021)
Riverbanks are very dynamic habitats for riparian vegetation strongly influenced byfluvial and geomorphic processes. This habitat type was severely reduced in the pastby river straightening and bank stabilisation. Restoration and establishment of newfloodplain streams promote this habitat, but a directed succession to later stages wasobserved many times. Our study aimed to analyse whether the often observeddirected succession of the streambank vegetation after restoration implementationcould be reversed by a natural flood along a newly created floodplain stream. Weinvestigated the effects of a natural flood in 2013 and different prerestorationconditions on species development in the riparian zone. Vegetation was studiedalong 12 transects in four different sections from 2011 to 2014. Species composi-tion differed strongly between the sections. Species richness was lowest in a newlydug steep section with high morphological dynamics and highest on wider flatstreambanks. Changes during the years reflecting different hydrological eventsvaried between sections. The high natural flood in 2013 reduced the cover of theherb layer and increased bare ground, which led in most sections to a loss of non-target species. Total target species richness did not change due to the natural flood,while target species showed a high turnover rate. In the following year, however,the flood‐induced development of species composition, in general, was reversed.Natural floods changed abiotic and biotic conditions along the streambank, but theydid not accelerate ecological restoration towards predefined target ecosystems.However, they were necessary to preserve the needed dynamic vegetation changesand species turnover to hinder the succession to later stages dominated by a fewspecies. Our study shows that riparian vegetation near the streambank can bemonitored most effectively in cross‐profile transects, both in the long‐term andevent‐related.
Objectives:
The purpose of this study was to determine the motor function of the abdominal muscles in singers with and without functional voice disorders and to examine them for possible differences. Additionally, the breathing behaviour and posture control was investigated.
Study Design
Observational study.
Methods:
Female subjects (n = 20) with differing levels of professional competence were used to provide the data for analysis. By using the Singing Voice Handicap Index (SVHI) the grade of dysphonia could be measured, and the subjects were organized in groups. The change of muscle thickness of the M. transversus abdominis (TVA) and the M. obliquus internus abdominis (OIA) during different singing tasks was measured by using ultrasound. The subjects were then asked to perform the Abdominal Hollowing Test (AHT) with the STABILIZER. Finally, the subjects were all filmed while singing. The videos recordings of the singing sessions were analysed by an independent clinical expert regarding breathing and secondary motor activities (SMA). For the statistical analysis, the Mann-Whitney-U Test and the Chi-Square-Test was mainly used.
Results:
The results showed a significantly thinner TVA in the group with dysphonia in comparison to the group without dysphonia. Ultrasound measurements showed significantly higher changes of muscle thickness of the TVA during singing tasks in the group with dysphonia. Regarding the AHT there was a significant difference between the two groups. The group with dysphonia was not able to increase the pressure by 15mmHg. Furthermore, the healthy subjects demonstrated abdominal breathing, while the group with dysphonia present with thoracic breathing. Additionally, it was noted that the subjects with dysphonia showed a higher level of associated movements especially at and/or on the lumbar spine, cervical spine and the left arm and shoulder.
Conclusion:
Differences in TVA-recruitment, breathing behaviour and secondary motor activities while singing were found. This study sparks new ideas for neuromusculoskeletal assessments and therapy.
Key Words
Transversus abdominis, Abdominal muscles, Dysphonia, Ultrasound, Singing voice, Singers
Die Landwirtschaft ist ein Wirtschaftszweig mit massiven Auswirkungen auf die biologische und agrobiodiverse Vielfalt. Nachhaltige Ernährung ist ein entscheidender politischer Hebel und eine realistische Chance, die Umweltauswirkungen des Agrar- und Ernährungssektors zu verringern und gleichzeitig die menschliche Gesundheit zu verbessern. Auswärts essen ist für viele Verbraucher eine immer häufiger anzutreffende Gewohnheit, und indem sie nachhaltige Gerichte anbieten, können Catering-Unternehmen eine zentrale Rolle spielen. Dazu müssen sie die Nachhaltigkeit ihres Lebensmittelangebots verstehen und richtig einschätzen können, aber es gibt noch keine gut etablierten Bewertungsinstrumente. Im Rahmen des NAHGAST-Projekts, zu dem diese Studie gehörte, wurde ein Instrument zur Bewertung der Nachhaltigkeit für Catering-Unternehmen entwickelt und getestet, das auf konkreten, pro Mahlzeit definierten Zielen basiert. Diese Studie befasst sich mit dem Mangel an Methoden zur Bewertung der Auswirkungen von Lebensmitteln auf die biologische Vielfalt, wobei der Schwerpunkt auf der Agrobiodiversität liegt. Die Arbeit veranschaulicht eine kontextspezifische Anwendung eines erweiterten DPSIR-Modells zur Strukturierung von Informationen und Auswahl von Indikatoren und schlägt eine transdisziplinäre Nutzung bestehender Messgrößen vor. Weitere Forschungsarbeiten sind erforderlich, um wissenschaftlich fundierte Zielwerte oder Nachhaltigkeitsspannen für jeden Indikator pro Mahlzeit zu definieren, damit diese berechnet werden können.
Die Stärken und Grenzen der Studie werden diskutiert.
The management of patients experiencing chronic orofacial pain is a great challenge, due to the complexity of chronic pain itself, combined with an increased peripheral sensitization in the craniofacial itself. Therefore, patients with orofacial pain may present a clear distortion of the somatorepresentation after some time. In this review, the authors develop a neurophysiological explanation of orofacial distortion, as well as propose assessment and treatment options, based on scarcely available scientific evidence and their own clinical experience. The assessments of facial somatosensory, cognitive-affective and motor dysfunctions are crucial to establish the most accurate treatment; the assessment tools are described in the article. Two-point discrimination, laterality recognition and emotion recognition are altered in patients with orofacial pain. Other sensorimotor assessment tools, such as motor acuity and auditory acuity, are also explained. Finally, the authors review their treatment proposals, based on the integration of brain training techniques and biobehavioral interventions. Somatosensory reintegration (tactile acuity training), facial emotion recognition, movement representation techniques, orofacial motor training and therapeutic patient education are explained in detail, and this may challenge new directions in rehabilitation and research.
Beratung leistet einen wichtigen Beitrag zur Stärkung und Stabilisierung der häuslichen Pflege. Ein geeignetes Instrument zur Unterstützung einer systematischen Situationsanalyse und zur Erfassung des Beratungsbedarfes kann die Qualität der Beratung verbessern und auf ein einheitliches Niveau heben. Auf Basis einer systematischen Literaturrecherche werden in diesem Beitrag acht Assessmentinstrumente vorgestellt, die für die Beratungsangebote nach SGB XI in Frage kommen. Dabei zeigt sich Entwicklungsbedarf für ein Instrument, welches die Besonderheiten des intrapersonalen Beratungsprozesses berücksichtigt und unabhängig vom gesetzlich definierten Beratungsanlass zum Einsatz kommen kann.
Background
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are frequent and serious complications after surgery. We aim to investigate the association between genetic variants in cholinergic candidate genes according to the Kyoto encyclopedia of genes and genomes - pathway: cholinergic neurotransmission with the development of POD or POCD in elderly patients.
Methods
This analysis is part of the European BioCog project (www.biocog.eu), a prospective multicenter observational study with elderly surgical patients. Patients with a Mini-Mental-State-Examination score ≤ 23 points were excluded. POD was assessed up to seven days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method and a patient chart review. POCD was assessed three months after surgery with a neuropsychological test battery. Genotyping was performed on the Illumina Infinium Global Screening Array. Associations with POD and POCD were analyzed using logistic regression analysis, adjusted for age, comorbidities and duration of anesthesia (for POCD analysis additionally for education). Odds ratios (OR) refer to minor allele counts (0, 1, 2).
Results
745 patients could be included in the POD analysis, and 452 in the POCD analysis. The rate of POD within this group was 20.8% (155 patients), and the rate of POCD was 10.2% (46 patients). In a candidate gene approach three genetic variants of the cholinergic genes CHRM2 and CHRM4 were associated with POD (OR [95% confidence interval], rs8191992: 0.61[0.46; 0.80]; rs8191992: 1.60[1.22; 2.09]; rs2067482: 1.64[1.10; 2.44]). No associations were found for POCD.
Conclusions
We found an association between genetic variants of CHRM2 and CHRM4 and POD. Further studies are needed to investigate whether disturbances in acetylcholine release and synaptic plasticity are involved in the development of POD.
Aims
Understanding fine-grain diversity patterns across large spatial extents is fundamental for macroecological research and biodiversity conservation. Using the GrassPlot database, we provide benchmarks of fine-grain richness values of Palaearctic open habitats for vascular plants, bryophytes, lichens and complete vegetation (i.e., the sum of the former three groups).
Location
Palaearctic biogeographic realm.
Methods
We used 126,524 plots of eight standard grain sizes from the GrassPlot database: 0.0001, 0.001, 0.01, 0.1, 1, 10, 100 and 1,000 m2 and calculated the mean richness and standard deviations, as well as maximum, minimum, median, and first and third quartiles for each combination of grain size, taxonomic group, biome, region, vegetation type and phytosociological class.
Results
Patterns of plant diversity in vegetation types and biomes differ across grain sizes and taxonomic groups. Overall, secondary (mostly semi-natural) grasslands and natural grasslands are the richest vegetation type. The open-access file ”GrassPlot Diversity Benchmarks” and the web tool “GrassPlot Diversity Explorer” are now available online (https://edgg.org/databases/GrasslandDiversityExplorer) and provide more insights into species richness patterns in the Palaearctic open habitats.
Conclusions
The GrassPlot Diversity Benchmarks provide high-quality data on species richness in open habitat types across the Palaearctic. These benchmark data can be used in vegetation ecology, macroecology, biodiversity conservation and data quality checking. While the amount of data in the underlying GrassPlot database and their spatial coverage are smaller than in other extensive vegetation-plot databases, species recordings in GrassPlot are on average more complete, making it a valuable complementary data source in macroecology.
Das 23. gehölzkundliche Winterseminar der Arbeitsgruppe Junge Dendrologen in der DDG fand im Herzen Deutschlands in der Lutherstadt Wittenberg statt. Wie in den vergangenen Jahren war als Tagungsort eine Jugendherberge gewählt worden. Ursprünglich sollte Quartier in der Jugendherberge in der Bauhaus-Stadt Dessau bezogen werden. Da diese bereits ausgebucht war, wurde nach Wittenberg ausgewichen, was für die Programmgestaltung vorteilhaft war.
Bruxismus ist keine Krankheit, sondern ein Sammelbegriff für Parafunktionen wie Zähnepressen oder Knirschen. Um Begleitsymptome des Bruxismus zu beeinflussen, ist eine Untersuchung des orofazialen und kraniozervikalen Systems sinnvoll. Die gefundenen auffälligen Zeichen leiten die Therapeuten in der muskuloskelettalen Therapie, die aus Hands-on und -off-Techniken besteht.
Conceptualising event value co-destruction and developing a future agenda for events research
(2021)
Purpose
Value co-destruction has received little attention in an event-related context. This appears surprising, given that the interactions among actors at an event may also reduce the value for other participants, stakeholders and that of the entire event or the event's service ecosystem. This paper first aims to conceptualise value co-destruction and to provide an overview of related research in an event context. Second, a future research agenda for value co-destruction processes in an event context is developed.
Design/methodology/approach
Journals of the “Scimago Journal and Country Rank” were systematically reviewed for the keywords “value co-destruction”, “value destruction” and “negative value co-creation”. A second literature review specifically aimed at the events context extended the search scope to non-Scimago journals, Google Scholar and Google Web using the same keywords. All identified articles were qualitatively analysed concerning (1) the conceptualisation of value co-destruction and (2) reasons for value co-destruction.
Findings
The review of previous research highlights a limited scope of analysis, a focus on value co-destruction as an outcome and on interactions at the meso-level. Based on these findings, a holistic definition of value co-destruction is proposed. The paper identifies two major directions for future studies on value co-destruction at events and suggests specific examples.
Originality/value
The paper contributes to a more holistic understanding of value co-creation and co-destruction in an event setting. For example, a clearer understanding of the interactions that reduce the overall value of an event may assist to better design valuable events in the future.
Consumer Acceptance and Market Potential of Iodine-Biofortified Fruit and Vegetables in Germany
(2021)
Biofortification of food crops with iodine is a novel approach to preventing iodine deficiency in humans. The present study analyses the consumer target groups and the market potential of iodine-biofortified fruit and vegetables in Germany. For this purpose, an online survey of 1016 German fruit and vegetable consumers was conducted to investigate the acceptance of different product categories as well as relevant criteria for the market launch. The results show that io-dine-biofortified fruit and vegetables are particularly attractive to consumers who purchase at farmers’ markets, organic food shops, and farm stores. Out of this group, 39% of consumers rate such iodine-rich foods as very appealing. They attach importance to food that naturally contains iodine and prefer produce from integrated domestic cultivation. With their focus on sustainability and naturalness, this group of consumers clearly differs from typical users of dietary supplements, who are primarily concerned with health benefits. However, overall about 85% of respondents would prefer biofortified fruits and vegetables to supplements to improve their iodine supply. The greatest market potential for iodine-biofortified fruit and vegetables is to be expected in super-markets, as this is the preferred food shopping location for most consumers. A total of 28% of those who buy here rate the biofortified foods presented as very appealing. Nevertheless, a successful market launch requires that the benefits of the new products are communicated according to the potential consumer group needs.
Abstract: Thermal response curves that depict the probability of occurrence along a thermal gradient are used to derive various species’ thermal properties and abilities to cope with warming. However, different thermal responses can be expected for different portions of a species range. We focus on differences in thermal response curves (TRCs) and thermal niche requirements for four freshwater fishes (Coregonus sardinella, Pungitius pungitius, Rutilus rutilus, Salvelinus alpinus) native to Europe at (1) the global and (2) European continental scale. European ranges captured only a portion of the global thermal range with major differences in the minimum (Tmin), maximum (Tmax) and average temperature (Tav) of the respective distributions. Further investigations of the model-derived preferred temperature (Tpref), warming tolerance (WT = Tmax − Tpref), safety margin (SM = Tpref − Tav) and the future climatic impact showed substantially differing results. All considered thermal properties either were under- or overestimated at the European level. Our results highlight that, although continental analyses have an impressive spatial extent, they might deliver misleading estimates of species thermal niches and future climate change impacts, if they do not cover the full species ranges. Studies and management actions should therefore favor whole global range distribution data for analyzing species responses to environmental gradients.
Thermal response curves that depict the probability of occurrence along a thermal gradient are used to derive various species’ thermal properties and abilities to cope with warming. However, different thermal responses can be expected for different portions of a species range. We focus on differences in thermal response curves (TRCs) and thermal niche requirements for four freshwater fishes (Coregonus sardinella, Pungitius pungitius, Rutilus rutilus, Salvelinus alpinus) native to Europe at (1) the global and (2) European continental scale. European ranges captured only a portion of the global thermal range with major differences in the minimum (Tmin), maximum (Tmax) and average temperature (Tav) of the respective distributions. Further investigations of the model-derived preferred temperature (Tpref), warming tolerance (WT = Tmax − Tpref), safety margin (SM = Tpref − Tav) and the future climatic impact showed substantially differing results. All considered thermal properties either were under- or overestimated at the European level. Our results highlight that, although continental analyses have an impressive spatial extent, they might deliver misleading estimates of species thermal niches and future climate change impacts, if they do not cover the full species ranges. Studies and management actions should therefore favor whole global range distribution data for analyzing species responses to environmental gradients.
Background: In longitudinal studies, observations are made over time. Hence, the single observations at each time point are dependent, making them a repeated measurement. In this work, we explore a different, counterintuitive setting: At each developmental time point, a lethal observation is performed on the pregnant or nursing mother. Therefore, the single time points are independent. Furthermore, the observation in the offspring at each time point is correlated with each other because each litter consists of several (genetically linked) littermates. In addition, the observed time series is short from a statistical perspective as animal ethics prevent killing more mother mice than absolutely necessary, and murine development is short anyway. We solve these challenges by using multiple contrast tests and visualizing the change point by the use of confidence intervals.
Results: We used linear mixed models to model the variability of the mother. The estimates from the linear mixed model are then used in multiple contrast tests.There are a variety of contrasts and intuitively, we would use the Changepoint method. However, it does not deliver satisfying results. Interestingly, we found two other contrasts, both capable of answering different research questions in change point detection: i) Should a single point with change direction be found, or ii) Should the overall progression be determined? The Sequen contrast answers the first, the McDermott the second. Confidence intervals deliver effect estimates for the strength of the potential change point. Therefore, the scientist can define a biologically relevant limit of change depending on the research question.
Conclusion: We present a solution with effect estimates for short independent time series with observations nested at a given time point. Multiple contrast tests produce confidence intervals, which allow determining the position of change points or to visualize the expression course over time. We suggest to use McDermott’s method to determine if there is an overall significant change within the time frame, while Sequen is better in determining specific change points. In addition, we offer a short formula for the estimation of the maximal length of the time series.
BACKGROUND: The Craniofacial Pain and Disability Inventory (CF-PDI) is a cross-culturally adapted instrument designed from a biopsychosocial perspective to measure pain, disability, and function in orofacial head and neck pain with shown psychometric properties; however, the German cross-cultural adaption is lacking.
OBJECTIVES: To carry out a transcultural translation of CF-PDI into German and assess its psychometric properties in patients with painful temporomandibular disorders (TMD) with respect to construct and clinical validity, internal consistency and reproducibility.
STUDY DESIGN: Multicenter, prospective, cross-sectional design.
SETTING: Patients (n = 398) were recruited from dental and physical therapy clinics in middle and south Germany.
METHODS: Structural validity was assessed using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). We investigated know-group validity by means of the scale’s potential to discriminate between affected and unaffected subjects. Multiple linear regression analysis was used to estimate convergent validity. We tested test-retest reliability by the intraclass correlation coefficient and the Internal consistency by Cronbach’s alpha, or each dimension separately, and the total score. Multiple linear regression analysis was used to estimate convergent validity.
RESULTS: Two hundred forty-six heterogeneous chronic craniofacial pain patients and 152 patients without complaints were recruited from the middle and south of Germany. The German version CF-PDI-G presents 21 items, 4 factors, and adequate psychometric properties. The test-retest reliability and internal consistency of the CF-PDI-G were both excellent for the entire instrument and also for all sub-scales (intraclass correlation coefficient [ICC] > 0.90) except for the comorbidities and interference with work which was acceptable (ICC = 0.69). Standard error of the measurement (SEM) and minimal detectable change values are sufficiently low. Assessment of clinical validity shows good potential of discrimination and classification into categories “no,” “mild,” “moderate,” and “severe.” The multiple linear regression model showed a strong association between neck disability index, Visual Analog Scale, and anamnestic questionnaire (supporting the scale’s convergent validity).
LIMITATIONS: Our sample has a higher prevalence of women and the sample was not recruited consecutively, which may lead to a biased estimation of psychometric properties.
CONCLUSIONS: The CF-PDI-G represents valid and reliable instrument to assess pain and disability in patients with orofacial pain and headache suitable for research and clinical practice.
In diesem Beitrag setzten sich Vertreterinnen und Vertreter der Hamburger Schule der Demokratiebildung ausführlich mit dem 16. Kinder- und Jugendbericht auseinander. Ihre Beiträge zur Demokratiebildung waren in dem Bericht der Expertenkommission vielfach zitiert, aber nicht systematisch entfaltet worden. Rolf Ahlrichs, Stephan Maykus, Elisabeth Richter, Helmut Richter, Wibke Riekmann und Benedikt Sturzenhecker greifen die Denkanstöße aus dem 16. Kinder- und Jugendbericht auf, um das Konzept der Demokratiebildung in der Kinder- und Jugendarbeit aus der Perspektive eines demokratischen Partizipations- und kommunalen Raumbegriffs schärfer zu konturieren. Nach Vorklärungen zu den Begriffen Demokratie und Demokratiebildung definieren sie einen Raumbegriff, der Mitgliedschaft einschließt, hauptsächlich in der Kommune verortet und an Institutionen gebunden ist. Nach diesen theoretischen Vorklärungen wenden sich die Autorinnen und Autoren der Demokratiebildung in der Offenen Kinder- und Jugendarbeit zu. Sie attestieren dem 16. Kinder- und Jugendbericht, dass er ein Recht von Kindern und Jugendlichen auf Politische Bildung als Demokratiebildung feststellt, dass er aber nicht klärt, wie sie diese Regelungen der Lebensführung in sozialpädagogischen Einrichtungen demokratisch mitbestimmen können. Das Autor/inn/enteam argumentiert, Demokratiebildung gelinge erst dann, wenn Kinder und Jugendliche das Recht hätten, die Regeln der gemeinsamen Lebensführung mitzugestalten. Ihr Vorschlag ist, Macht und Einfluss von Kindern und Jugendlichen einerseits und von Mitarbeitenden andererseits in den Einrichtungen der Offenen Kinder- und Jugendarbeit nach dem Vereinsrecht aufzuteilen und Jugendarbeit so demokratisch zu gestalten. Allerdings fehle dazu bisher eine geklärte Mitgliedschaft und damit die gegenseitige Verbindlichkeit einer Entscheidungsgemeinschaft, stellt das Team fest. Das führe dazu, dass Einrichtungen der Offenen Kinder- und Jugendarbeit bisher oft paternalistisch strukturierte Konsumfamilien seien, in denen Jugendliche auf Entscheidungsmacht weitgehend verzichteten. So könne Demokratiebildung nicht als selbsttätige Aneignung von Demokratie praktisch umgesetzt werden. Im 16. Kinder- und Jugendbericht bleibe Demokratiebildung in der Offenen Kinder- und Jugendarbeit eine pädagogisch arrangierte Scheindemokratie. Das Team äußert sich ebenfalls zur verbandlichen Jugendarbeit bzw. Schule und ihrer Rolle in der Demokratie und zeigt auf, dass der Bericht demokratiebildende Potenziale auch hier nicht hinreichend benennt.
Der folgende Beitrag setzt sich mit dem Konzept parasozialer Meinungsführerschaft auseinander und nimmt die Corona-Pandemie als Anlass, sich dem Konzept sowie den Auswirkungen parasozialer Meinungsführerschaft auf Einstellungen und Handeln anzunähern. Im Jahr 2020 waren unterschiedliche Personen in den Medien
präsent, die sich zu der Situation der Corona-Pandemie in Deutschland geäußert haben. Aufgrund der theoretischen Grundlagen nach Leißner et al. (2014) werden die Vermutungen aufgestellt, dass einige dieser Medienpersonen als parasoziale Meinungsführer bezüglich der Pandemie fungierten und in unterschiedlicher Stärke Einstellungen und Handeln beeinflussen konnten. Der Grad der Einflussnahme hängt vermutlich sowohl mit den Eigenschaften der Meinungsführer selbst als auch mit den Merkmalen ihrer Rezipienten zusammen. Im Rahmen der Bachelorarbeit wurde eine quantitative, vollstandardisierte Befragung durchgeführt und parasoziale Meinungsführer zum Thema ‚Corona-Pandemie´ konnten identifiziert werden. Diese stammen aus unterschiedlichen gesellschaftlichen Bereichen. Die parasozialen Meinungsführer können bezüglich des thematischen Schwerpunkts der Pandemie unterschiedlich intensiven Einfluss auf die Probanden dieser Untersuchung nehmen. Außerdem gibt es einen Zusammenhang zwischen der Stärke der Einflussnahme durch die Meinungsführer und dem Alter ihrer Rezipienten.
Die Direktvermarktung von landwirtschaftlichen Erzeugnissen spielt in Niedersachsen eine bedeutende Rolle zur Einkommensaufwertung der landwirtschaftlichen Betriebe. Das Internet ist dabei mittlerweile ein entscheidendes Medium zur Kundenansprache. Diese Studie hat daher die Zielstellung, die Bildkommunikation der landwirtschaftlichen Direktvermarkter in Niedersachsen im Rahmen der klassischen Homepage zu untersuchen. Entsprechendes Bildmaterial der Erstansicht der Homepages von Direktvermarktungsbetrieben wurde dafür einer qualitativen und quantitativen Analyse unterzogen. 258 Homepages von niedersächsischen Direktvermarktern wurden in die Auswertung einbezogen. Die Auswertung zeigt: Mehr als jeder zweite niedersächsische Direktvermarkter stellt Gebäude auf der Erstansicht seiner Webseite dar. Es handelt sich hierbei überwiegend um historisch aussehende Gebäude. Weiterhin konnte ermittelt werden, dass neben Gebäuden auch Personen, Tiere, Obst, Gemüse, Pflanzen, Produkte sowie Landschaften auf den Erstansichten der Webseiten dargestellt werden.
Äpfel besitzen mehrere Allergene, die beim Essen innerhalb von 5–10 min zu Symptomen im Mundbereich führen – und deshalb von Apfelallergikern nicht gegessen werden können. In Deutschland haben rund 7,5 Mio. Menschen spezifische Antikörper gegen das Hauptallergen (Mal d 1) in Äpfeln entwickelt und sind damit sensibilisiert. Mindestens 3,5 Mio. von ihnen entwickeln die teilweise erheblichen allergischen Symptome als Ausdruck eines Oralen Allergie-Syndroms. Es gibt bisher keine medikamentöse Therapie gegen diese Allergie.
Apfelallergiker können daher nur auf Äpfel ganz verzichten, oder vorher erhitzte Äpfel essen oder Sorten suchen, die wenig Allergene enthalten und deshalb als allergikerfreundliche Apfelsorten bezeichnet werden können.
Alleinige Bestimmungen von Allergenen im Labor können nicht voraussagen, ob ein Apfel ohne allergische Symptome von Apfelallergikern gegessen werden kann; dazu bedarf es klinischer Prüfungen.
Wir beschreiben eine standardisierte klinische, orale Provokationstestung, die zur Charakterisierung eines allergenarmen, allergikerfreundlichen Apfels bzw. Apfelsorte benutzt werden kann.. Die Ergebnisse solcher mindestens dreijährigen Tests können zur Verleihung des ECARF-Siegels für allergikerfreundliche Produkte genutzt werden.
Extending assessments of climate change-induced range shifts via correlative species distribution models by including species traits is crucial for conservation planning. However, comprehensive assessments of future distribution scenarios incorporating responses of biotic factors are poorly investigated. Therefore, the aim of our study was to extend the understanding about the combined usage of species traits data and species distribution models for different life stages and distribution scenarios. We combine global model predictions for the 2050s and thermal performances of Salmo trutta and Salmo salar under consideration of different life stages (adults, juveniles, eggs), timeframes (monthly, seasonally, yearly), and dispersal scenarios (no dispersal, free dispersal, restricted dispersal). We demonstrate that thermal performances of different life stages will either increase or decrease for certain time periods. Model predictions and thermal performances imply range declines and poleward shifts. Dispersal to suitable habitats will be an important factor mitigating warming effects; however, dams may block paths to areas linked to high performances. Our results emphasize enhanced inclusion of critical periods for species and proper dispersal solutions in conservation planning.
Introduction
Observations show that foam rolling improves joint movements. Likewise, it can be stated that a vibration stimulation of the tissue leads to improved joint mobility.
Method
This study investigates whether the combination of foam rolling and vibrations (31 Hz) can influence the sliding of the thoracolumbar fascia more effectively than normal foam rolling. 45 subjects participated in the study and were divided into a foam roll with additional vibration group (FRV), a foam roll group (FR) and a control group (CG). The intervention groups rolled out the gluteal muscles, the lateral trunk and the upper and lower back. Mobility measures were taken pre and post the respective intervention. Subsequent cross correlation software analysis quantified the sliding of the fascia and calculated its shear strain mobility (SSM).
Results
The sliding of the thoracolumbar fascia improved significantly within the FRV by 2.83 mm (SD ± 1.08/p < .001), in the FR by 0.96 mm (SD ± 0.43/p < .001) and in the CG decreased the sliding by 0.1401 mm (SD ± 0.28/p = .076). The fascia/fascia SSM increased in the FRV by 22.61% (SD ± 15.64/p < .001), in the FR by 11.41% (SD ± 20.38/p = .056) and in the CG decreased the SSM by 0.9473% (SD ± 11.35/p < .751). The lumbar movement increased in both intervention groups, but showed no significant result.
Conclusion
The use of a foam roll with additional vibration and standard intervention have increased thoracolumbar fascia sliding and lumbar movements. The improved shear strain mobility can be attributed to the multi-activity of mechanoreceptors, such as Pacini- and Ruffini-Bodies.
Objectives: This study aimed at the construction of what the core of eHealth policy making is, offering new perspectives about high priority procedures along the policy making process
Methods: Following Grounded Theory methodology, 59 qualitative telephone interviews with a broad variety of stakeholders from Austria, Switzerland and Germany were conducted
Results: The findings hinted at five priorities of eHealth policy making: strategy, consensus-building, decision-making, implementation and evaluation that emerged from the stakeholders’ perception of the eHealth policy. Hereby strategy, consensus-building and implementation gained the highest attention
Conclusions: These findings suggest three high priorities in eHealth policy: 1) developing and pursuing a consistent eHealth strategy, 2) investing time and resources into consensus-building to clear up difficulties early on in the process, 3) governing implementation towards serving patient care through systems fit for practice.
Public Interest Summary: Digitalisation is playing an increasingly crucial role in providing high quality health care. However, different countries have pursued different political paths. In this study, we wanted to know how the stakeholders perceived the political process in their country to identify strengths and weaknesses. We, therefore, conducted interviews about digital health policy with experts from Austria, Switzerland and Germany covering the full spectrum of stakeholders. The findings suggest three political musts: 1) a convincing and coherent strategy followed throughout the entire process, 2) consensus- building among the stakeholders, 3) using “fit for practice” as the yardstick to measure political success.
PR- und Kommunikationsagenturen gelten als Frauendomäne, mit einer Ausnahme. In den obersten Führungsebenen sind immer noch wenige weibliche Führungskräfte vertreten. Der vorliegende Beitrag nimmt Frauen in Führungspositionen in deutschen Agenturen in den Blick. Die Forschungsfragen beziehen sich auf Faktoren, die Frauen auf einem vertikalen Karriereweg unterstützen, die Bedeutung des Faktors Geschlecht und die Führungsstile von Frauen in PR- und Kommunikationsagenturen.
Diese Thematiken finden derzeit im Forschungsbereich PR wenig Beachtung – anders als in anderen Bereichen. Um die Fragen zu beantworten, wurden im Rahmen einer Masterarbeit sieben leitfadengestützte Interviews mit Frauen im Management von großen PR- und Kommunikationsagenturen in Deutschland geführt. Die Ergebnisse zeigen, dass flexible, offene Organisationskulturen und unterstützende Mentor*innen insbesondere für Frauen mit Kindern für eine vertikale Karriere förderlich sind. Ein Herausstellen der wenigen Führungsfrauen in der Branche wird als nicht zielführend bewertet, um mehr Frauen für das Topmanagement zu gewinnen. Bezüglich des Führungsstils präferieren die Befragten einen Stil mit kooperativen und kollaborativen Elementen.
Im Rahmen eines Online-Experiments wird erstmals der Frage nachgegangen, welchen Einfluss die Selbstdarstellung im Anschreiben auf die Bewertung der Bewerber/innen nimmt. Verglichen werden zwei Varianten der Selbstdarstellung (einfach vs. differenziert) mit einer Kontrollgruppe ohne Anschreiben. Im Ergebnis zeigte sich, dass eine differenzierte Selbstdarstellung zu einer signifikant positiveren Bewertung führt. Bewerber/innen werden als leistungsstärker, sozial kompetenter und als geeigneter für die ausgeschriebene Stelle erlebt. Zudem werden sie mit größerer Wahrscheinlichkeit zum Einstellungsinterview eingeladen und es wird eine größere Erfolgswahrscheinlichkeit im gesamten Auswahlverfahren prognostiziert. Eine einfache Selbstdarstellung führt hingegen zu einer negativeren Bewertung als ein komplett fehlendes Anschreiben. Angesichts der bestenfalls fragwürdigen Validität des Anschreibens werden die Befunde als unerwünschte Urteilsverzerrung interpretiert. Die Erfahrung der Entscheidungsträger/innen nimmt keinen Einfluss auf das Ausmaß des Urteilsverzerrung.
In einem Online-Experiment wird untersucht, wie sich Arbeitgeberbewertungen im Internet auf die Wahrnehmung eines Arbeitgebers durch 219 potentielle Bewerberinnen und Bewerber auswirken. Verglichen werden drei Untersuchungsgruppen: 1. Selbstdarstellung eines Arbeitgebers auf der eigenen Website 2. Selbstdarstellung des Arbeitgebers zuzüglich positiver Bewertung des Arbeitgebers in einem Internetportal 3. Selbstdarstellung zuzüglich negativer Bewertung des Arbeitgebers im Internetportal. Als abhängige Variablen dienen Einschätzungen des Arbeitgeberi-mages, der wahrgenommenen Arbeitgeberattraktivität sowie der eigenen Beschäftigungsintention. Im Ergebnis zeigt sich, dass die negative Bewertung des Arbeitgebers im Internetportal auf allen abhängigen Variablen zu signifikant geringeren Werten führt, während die positive Bewertung keinen Unterschied zur Kontrollbedingung bewirkt. Zudem geht die wahrgenommene Glaubwürdigkeit der Arbeitgeberwebsite mit positiveren Ergebnissen auf allen abhängigen Variablen einher. Für die Praxis bedeutet dies, dass es Arbeitgebern wahrscheinlich wenig nützt, wenn sie sich gefälschte positive Bewertungen auf entsprechenden Portalen „kaufen“ bzw. diese selbst dort platzieren.
Am 16.12.2020 hat das Bundeskabinett den Entwurf eines Gesetzes zur Stärkung der Finanzmarktintegrität beschlossen. Dies ist eine Reaktion auf den Bilanzskandal beim ehemaligen DAX-Konzern Wirecard. Mit dem Gesetzentwurf werden eine Reduzierung von Schwachstellen bei der Kontrolle von Bilanzen, eine Stärkung der Unabhängigkeit der Abschlussprüfer sowie eine Verbesserung von internen Kontrollen in Unternehmen angestrebt. So sollen der Finanzplatz Deutschland an Integrität sowie Attraktivität gewinnen und verlorenes Vertrauen wieder aufgebaut werden. Der nachfolgende Beitrag beschäftigt sich mit der Entstehung und ausgewählten Inhalten des Gesetzentwurfs und gibt anschließend einen Überblick über die aktuelle Diskussion der Reformpläne in der Literatur.
Background
In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammation. Epigenetic modifications of the chromatin confer plasticity to the genetic information and give insight into how tissues use the genetic information to adapt to environmental factors. The oral mucosa is particularly exposed to environmental stressors such as a variable microbiota. Likewise, persistent oral inflammation is the most important intrinsic risk factor for the oral inflammatory disease periodontitis and has strong potential to alter DNA-methylation patterns. The aim of the current study was to identify epigenetic changes of the oral masticatory mucosa in response to long-term inflammation that resulted in periodontitis.
Methods and results
Genome-wide CpG methylation of both inflamed and clinically uninflamed solid gingival tissue biopsies of 60 periodontitis cases was analyzed using the Infinium MethylationEPIC BeadChip. We validated and performed cell-type deconvolution for infiltrated immune cells using the EpiDish algorithm. Effect sizes of DMPs in gingival epithelial and fibroblast cells were estimated and adjusted for confounding factors using our recently developed “intercept-method”. In the current EWAS, we identified various genes that showed significantly different methylation between periodontitis-inflamed and uninflamed oral mucosa in periodontitis patients. The strongest differences were observed for genes with roles in wound healing (ROBO2, PTP4A3), cell adhesion (LPXN) and innate immune response (CCL26, DNAJC1, BPI). Enrichment analyses implied a role of epigenetic changes for vesicle trafficking gene sets.
Conclusions
Our results imply specific adaptations of the oral mucosa to a persistent inflammatory environment that involve wound repair, barrier integrity, and innate immune defense.
Hintergrund
Das Bundesministerium für Bildung und Forschung (BMBF) initiierte 2016 die Open-Access-Initiative. Open Access bedeutet, Wissen online kostenlos freizugänglich zu machen. Dieser Anspruch setzt eine Digitalisierung voraus, die hochschulübergreifend professionelles Wissen öffentlich macht. Dazu passt die Etablierung einer entsprechenden Online-Datenbank.
Ziel
Mithilfe einer Online-Befragung die Erwartungen potentieller Nutzer an eine Volltextdatenbank zu untersuchen. Mittels eines Fragebogens sollen Nutzerverhalten, Bedürfnisse, Notwendigkeiten erforscht sowie Ideen, Anregungen, persönliche Einschätzungen und mögliche Vor- und Nachteile erfasst werden.
Methode
Durchführung einer Online-Befragung mit 20 Fragen, welche in vier Abschnitte eingeteilt wurden. Geschlossene Fragen wurden deskriptiv ausgewertet, offene Fragen wurden mit der Kernsatzmethode nach Leithäuser und Volmerg (1988) ausgewertet.
Ergebnisse
Insgesamt 84,87 % der 337 Befragten zeigten Interesse an einer Volltextdatenbank für Abschlussarbeiten aus den Therapiewissenschaften. Wünsche der Befragten konnten in den Anforderungskatalog für die zu entwickelnde Volltextdatenbank aufgenommen werden. 67,95 % der Befragten würden sich ein Profil in einer Volltextdatenbank anlegen. Die Vorstellung, eine Abschlussarbeit in einem Videoporträt anzulegen, wurde hingegen von 36,50 % als nicht nützlich bewertet.
Schlussfolgerung
Anhand der Online-Befragung konnten die Rechercheaktivität und die Wünsche an eine Volltextdatenbank abgefragt werden. Die Nutzerakzeptanz kann erst zu einem späteren Zeitpunkt hinreichend bewertet werden, mithilfe einer Evaluationsstudie.