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Institute
The apple fruit (Malus domestica L. Borkh) is one of the most popular fruits worldwide. Beyond their beneficial properties, apples contain proteins that trigger allergic reactions in susceptible consumers. Mal d1 to d4 are allergens present in a variety of different isoforms in apples. In this study, we used proteomics to quantify all four Mal d proteins in 52 apple genotypes with varying allergenic potentials. A total of 195, 17, 14, and 18 peptides were found to be related to Mal d1, d2, d3, and d4 proteins, respectively of which 25 different Mal d proteins could be unambiguously identified. The allergenic potential of the Mal d isoforms was characterized by comparing the isoform abundance with the allergenic score of genotypes from oral challenge tests. The detected Mal d peptides presumably have different IgE binding properties and could be used as potential molecular markers to discriminate between hypoallergenic and hyperallergenic cultivars.
Objectives: To measure and assess the economic impact of adherence to a single quality indicator (QI) regarding weaning from invasive ventilation.
Design: Retrospective observational single-centre study, based on electronic medical and administrative records.
Setting: Intensive care unit (ICU) of a German university hospital, reference centre for acute respiratory distress syndrome.
Participants: Records of 3063 consecutive mechanically ventilated patients admitted to the ICU between 2012 and 2017 were extracted, of whom 583 were eligible adults for further analysis. Patients’ weaning protocols were evaluated for daily adherence to quality standards until ICU discharge. Patients with <65% compliance were assigned to the low adherence group (LAG), patients with ≥65% to the high adherence group (HAG).
Primary and secondary outcome measures: Economic healthcare costs, clinical outcomes and patients’ characteristics.
Results: The LAG consisted of 378 patients with a median negative economic results of −€3969, HAG of 205 (−€1030), respectively (p<0.001). Median duration of ventilation was 476 (248; 769) hours in the LAG and 389 (247; 608) hours in the HAG (p<0.001). Length of stay (LOS) in the LAG on ICU was 21 (12; 35) days and 16 (11; 25) days in the HAG (p<0.001). LOS in the hospital was 36 (22; 61) days in the LAG, and within the HAG, respectively, 26 (18; 48) days (p=0.001).
Conclusions: High adherence to this single QI is associated with better clinical outcome and improved economic returns. Therefore, the results support the adherence to QI. However, the examined QI does not influence economic outcome as the decisive factor.
During gestation, the most drastic change in oxygen supply occurs with the onset of ventilation after birth. As the too early exposure of premature infants to high arterial oxygen pressure leads to characteristic diseases, we studied the adaptation of the oxygen sensing system and its targets, the hypoxia-inducible factor- (HIF-) regulated genes (HRGs) in the developing lung. We draw a detailed picture of the oxygen sensing system by integrating information from qPCR, immunoblotting, in situ hybridization, and single-cell RNA sequencing data in ex vivo and in vivo models. HIF1α protein was completely destabilized with the onset of pulmonary ventilation, but did not coincide with expression changes in bona fide HRGs. We observed a modified composition of the HIF-PHD system from intrauterine to neonatal phases: Phd3 was significantly decreased, while Hif2a showed a strong increase and the Hif3a isoform Ipas exclusively peaked at P0. Colocalization studies point to the Hif1a-Phd1 axis as the main regulator of the HIF-PHD system in mouse lung development, complemented by the Hif3a-Phd3 axis during gestation. Hif3a isoform expression showed a stepwise adaptation during the periods of saccular and alveolar differentiation. With a strong hypoxic stimulus, lung ex vivo organ cultures displayed a functioning HIF system at every developmental stage. Approaches with systemic hypoxia or roxadustat treatment revealed only a limited in vivo response of HRGs. Understanding the interplay of the oxygen sensing system components during the transition from saccular to alveolar phases of lung development might help to counteract prematurity-associated diseases like bronchopulmonary dysplasia.
Background
A peripheral venous catheter (PVC) is the most widely used device for obtaining vascular access, allowing the administration of fluids and medication. Up to 25% of adult patients, and 50% of pediatric patients experience a first-attempt cannulation failure. In addition to patient and clinician characteristics, device features might affect the handling and success rates. The objective of the study was to compare the first-attempt cannulation success rate between PVCs with wings and a port access (Vasofix® Safety, B. Braun, abbreviated hereon in as VS) with those without (Introcan® Safety, B. Braun, abbreviated hereon in as IS) in an anesthesiological cohort.
Methods
An open label, multi-center, randomized trial was performed. First-attempt cannulation success rates were examined, along with relevant patient, clinician, and device characteristics with univariate and multivariate analyses. Information on handling and adherence to use instructions was gathered, and available catheters were assessed for damage.
Results
Two thousand three hundred four patients were included in the intention to treat analysis. First-attempt success rate was significantly higher with winged and ported catheters (VS) than with the non-winged, non-ported design (IS) (87.5% with VS vs. 78.2% with IS; PChi < .001). Operators rated the handling of VS as superior (rating of “good” or “very good: 86.1% VS vs. 20.8% IS, PChi < .001). Reinsertion of the needle into the catheter after partial withdrawal—prior or during the catheterization attempt—was associated with an increased risk of cannulation failure (7.909, CI 5.989–10.443, P < .001 and 23.023, CI 10.372–51.105, P < .001, respectively) and a twofold risk of catheter damage (OR 1.999, CI 1.347–2.967, P = .001).
Conclusions
First-attempt cannulation success of peripheral, ported, winged catheters was higher compared to non-ported, non-winged devices. The handling of the winged and ported design was better rated by the clinicians. Needle reinsertions are related to an increase in rates of catheter damage and cannulation failure.
Background
To detect changes in biological processes, samples are often studied at several time points. We examined expression data measured at different developmental stages, or more broadly, historical data. Hence, the main assumption of our proposed methodology was the independence between the examined samples over time. In addition, however, the examinations were clustered at each time point by measuring littermates from relatively few mother mice at each developmental stage. As each examination was lethal, we had an independent data structure over the entire history, but a dependent data structure at a particular time point. Over the course of these historical data, we wanted to identify abrupt changes in the parameter of interest - change points.
Results
In this study, we demonstrated the application of generalized hypothesis testing using a linear mixed effects model as a possible method to detect change points. The coefficients from the linear mixed model were used in multiple contrast tests and the effect estimates were visualized with their respective simultaneous confidence intervals. The latter were used to determine the change point(s). In small simulation studies, we modelled different courses with abrupt changes and compared the influence of different contrast matrices. We found two contrasts, both capable of answering different research questions in change point detection: The Sequen contrast to detect individual change points and the McDermott contrast to find change points due to overall progression. We provide the R code for direct use with provided examples. The applicability of those tests for real experimental data was shown with in-vivo data from a preclinical study.
Conclusion
Simultaneous confidence intervals estimated by multiple contrast tests using the model fit from a linear mixed model were capable to determine change points in clustered expression data. The confidence intervals directly delivered interpretable effect estimates representing the strength of the potential change point. Hence, scientists can define biologically relevant threshold of effect strength depending on their research question. We found two rarely used contrasts best fitted for detection of a possible change point: the Sequen and McDermott contrasts.
Intensive care units (ICU) are often overflooded with alarms from monitoring devices which constitutes a hazard to both staff and patients. To date, the suggested solutions to excessive monitoring alarms have remained on a research level. We aimed to identify patient characteristics that affect the ICU alarm rate with the goal of proposing a straightforward solution that can easily be implemented in ICUs. Alarm logs from eight adult ICUs of a tertiary care university-hospital in Berlin, Germany were retrospectively collected between September 2019 and March 2021. Adult patients admitted to the ICU with at least 24 h of continuous alarm logs were included in the study. The sum of alarms per patient per day was calculated. The median was 119. A total of 26,890 observations from 3205 patients were included. 23 variables were extracted from patients' electronic health records (EHR) and a multivariable logistic regression was performed to evaluate the association of patient characteristics and alarm rates. Invasive blood pressure monitoring (adjusted odds ratio (aOR) 4.68, 95%CI 4.15–5.29, p < 0.001), invasive mechanical ventilation (aOR 1.24, 95%CI 1.16–1.32, p < 0.001), heart failure (aOR 1.26, 95%CI 1.19–1.35, p < 0.001), chronic renal failure (aOR 1.18, 95%CI 1.10–1.27, p < 0.001), hypertension (aOR 1.19, 95%CI 1.13–1.26, p < 0.001), high RASS (aOR 1.22, 95%CI 1.18–1.25, p < 0.001) and scheduled surgical admission (aOR 1.22, 95%CI 1.13–1.32, p < 0.001) were significantly associated with a high alarm rate. Our study suggests that patient-specific alarm management should be integrated in the clinical routine of ICUs. To reduce the overall alarm load, particular attention regarding alarm management should be paid to patients with invasive blood pressure monitoring, invasive mechanical ventilation, heart failure, chronic renal failure, hypertension, high RASS or scheduled surgical admission since they are more likely to have a high contribution to noise pollution, alarm fatigue and hence compromised patient safety in ICUs.
The study aimed to investigate inactivation of naturally occurring microorganisms and quality of red pepper paste treated by high pressure processing (HPP). Central composite rotatable design was employed to determine the impacts of pressure (100–600 MPa) and holding time (30–600 s). HPP at 527 MPa for 517 s reduced aerobic mesophilic bacteria count by 4.5 log CFU/g. Yeasts and molds counts were reduced to 1 log CFU/g at 600 MPa for 315 s. Total phenols, carotenoids and antioxidants activity ranged from 0.28 to 0.33 g GAE/100 g, 96.0–98.4 mg βc/100 g and 8.70–8.95 μmol TE/g, respectively. Increase (2.5–6.7%) in these variables was observed with increasing pressure and holding time. Total color difference (ΔE∗) values (0.2–2.8) were within the ranges of ‘imperceptible’ to ‘noticeable’. Experimental results were fitted satisfactorily into quadratic model with higher R2 values (0.8619–0.9863). Optimization process suggested treatment of red pepper paste at 536 MPa for 125 s for maximum desirability (0.622). Validation experiments confirmed comparable percentage of relative errors. Overall, this technique could be considered as an efficient treatment for the inactivation of microorganisms that naturally occur in red pepper paste with minimal changes in its characteristics.
Повышение эффективности снятия покровной ткани с плодов томата импульсным электрическим полем
(2022)
Electrophysical technologies are a global trend of sustainable agriculture and food industry. Peeling is an energy-intensive procedure of fruit and vegetable processing. The research featured the effect of pulsed electric field (PEF) treatment on tomato peeling effectiveness. The assessment included such factors as specific effort, energy costs, and product losses in comparison with thermal and electrophysical methods. Tomatoes of Aurora variety underwent a PEF treatment at 1 kV/cm. The expended specific energy was 1, 5, and 10 kJ/kg. The tomatoes were visually evaluated with optical microscopy before and after processing. The peeling effectiveness and mass loss were measured with a texture analyzer and digital scales. The PEF treatment decreased the specific force of mechanical peel removal by 10% (P < 0.05). The mass loss decreased by 4% (P < 0.05) at 1 kJ/kg. The PEF method resulted in cell electroporation, which activated the internal mass transfer of moisture from the endocarp region between the mesocarp and the integumentary tissue. The hydrostatic pressure produced a layer of liquid, which facilitated the peeling. In comparison with thermal treatment (blanching), ohmic heating, and ultrasonic processing, the PEF technology had the lowest production losses and energy costs. The research proves the prospects of the PEF treatment in commercial tomato processing.
Applications of pulsed electric fields for processing potatoes: Examples and equipment design
(2022)
In the last two decades, pulsed electric fields (PEF) have successfully been introduced into the food industry, as one of the most promising and "game changing" technologies. This review is devoted to the recent applications of pulsed electric fields used in processing potatoes. The potato processing market size was estimated to be ca. USD 24.83 billion (2018) and with an annual growth rate of 5.2%. The physicochemical characteristics of potatoes and the specificity of potato processing lines makes a pulsed electric field very versatile and flexible allowing one to achieve different technological aims by its implementation into technological lines. In this paper, a short analysis of the potato structure and its nutritional properties, applications of moderate electric fields, ohmic heating, and pulsed electric fields are presented. Moreover, the basic electroporation effects, metabolic responses, texture modification and different PEF assisted processes applied to the potato are discussed. Finally, some examples of commercial applications and a brief description of the available equipment for the PEF processing of potatoes are presented.
The impact of Pulsed Electric Field (PEF) processing pre-treatment on the texture and kinetics of in vitro starch digestibility of French fries made from two potato cultivars (Solanum tuberosum L.) containing dry matter content ranging from 19 to 22% was investigated. Whole and steam-peeled potato tubers were treated with a pilot scale PEF unit (electric field strength of 1.1 and 1.9 kV/cm with energy input <10 kJ/kg or ∼50 kJ/kg). This trial was carried out in a commercial French-fry plant using an industrial scale cutter, blancher, fryer and blast-freezer to prepare the frozen par-fried French fry samples. After subsequent final batch frying of the frozen fries, at 180 °C for 3 min to mimic the typical preparation practice at restaurant, retail and household, the outer crust of the fries produced from PEF-treated potatoes was significantly harder (9.4–16.3 N) than crust produced from untreated potatoes (6.9–8.5 N). High intensity (1.9 kV/cm with energy input ∼50 kJ/kg) PEF processing was found to cause defects (i.e. hollowness in the internal core) in the fries. A fractional conversion model was a good fit for the starch digestion kinetics of all French fry samples during the small intestinal phase (based on standardised INFOGEST static in vitro digestion assay). A lower % of total starch hydrolysis was predicted for French fries produced from high dry matter (>21%) tubers pretreated with PEF at electric field strength of 1.9 kV/cm. The findings generated in this study demonstrate PEF pretreatment may influence the texture of French fries and the extent of starch digestion that occurs.
Over the past decade, the proliferation of entrepreneurial ventures and small firms with sustainable business models have pushed the sustainability agenda in the fashion industry. Despite prominent success stories, these companies often encounter significant operative challenges that hinder growth or even cause business failure. This paper adopts a qualitative research design and uses data gathered during 18 expert interviews with entrepreneurs and executive managers of 18 firms from 13 countries to identify and explore the dominant challenges that micro- and small-sized sustainable fashion companies struggle with. The results indicate that communicating with consumers is perceived as surprisingly difficult, especially because sustainable brands need to justify higher prices and explain the added benefits of their products. Second, resource constraints lead to operative friction and overburdening of the decision makers and their small management teams. Third, sustainable sourcing and production processes are economically difficult in an industry that continues to occupy a mass and low-cost logic. Against the background of these insights, a range of managerial recommendations are developed and contextualized in the framework of the Business Model Canvas. This novel approach makes the suggestions which are rooted in the resource-based view actionable and supports sustainable businesses to better manage their operations and achieve growth. For example, collaborative approaches with different stakeholders may mitigate constraints across all three identified problem areas.
Complete diets for laying hens are usually offered in meal form. This form initially promotes the laying hens’ natural feed intake behavior and allows them to satisfy their pecking behavior. At the same time, it can also cause difficulties, because it consists of different particles and is not a homogeneous unit. A homogeneous mixture is essential to ensure that each laying hen in the flock can meet its nutritional needs. If feed exhibits a wide particle size distribution, this can promote feed segregation during transport and selective feed intake behavior of laying hens. These two processes sometimes lead to significant differences between the composition of the feed produced and the composition of the feed that is finally ingested by the laying hens. Multi-stage sampling can be used to investigate progressing differences in feed composition. In this study, samples of different complete diets for laying hens (n = 76) were collected from ten organic farms in Germany to examine their particle size distributions (dry sieve analysis). Samples were taken at four different locations (V1 = loading, V2 = silo, V3 = at the beginning of the feed chain, V4 = at the end of the feed chain) in each farm. There was a tendency for V1 and V2 to be characterized by high proportions of particles between 1400 and 3150 µm (V1 = 61.2%, V2 = 43.5%). V3 and V4 consisted mainly of particles of size 500–800 µm and 200–400 µm, respectively. The lowest proportions across all variants were in the range above 3150 µm (V1 = 2.20%, V2 = 1.30%, V3 = 1.00%, V4 = 0.400%) and between 400 and 500 µm (V1 = 2.50%, V2 = 4.50%, V3 = 5.70%, V4 = 6.60%). The mean value comparison of the proportions of sieve mesh sizes from 200 to 1000 µm resulted in: V1 < V2 < V3 < V4; and of sieve mesh sizes between 1400 and 2000 µm in: V1 > V2 > V3 > V4. This observation can be explained by segregation of the feed during transport and a selective feeding behavior of the laying hens. However, trends were discontinuous and varied between the farms. Deviations from the guideline values were found in particular for particle sizes in the range of 1000 to 1400 µm.
25-hydroxycholecalciferol (25-OHD3) formed via hepatic hydroxylation from vitamin D, cholecalciferol, represents the precursor of the biologically active vitamin D hormone, 1,25-dihydroxyvitamin D. Due to a higher absorption rate and the omission of one hydroxylation, dietary supplementation of 25-OHD3 instead of vitamin D3 is considered to be more efficient as plasma concentrations of 25-OHD3 are increased more pronounced. The present review summarises studies investigating potential beneficial effects on mineral homeostasis, bone metabolism, health status and performance in sows, piglets and fattening pigs. Results are inconsistent. While most studies could not demonstrate any or only a slight impact of partial or total replacement of vitamin D3 by 25-OHD3, some experiments indicated that 25-OHD3 might alter physiological processes when animals are challenged, for example, by a restricted mineral supply.
To investigate the influence of two dietary sources of vitamin D on the vitamin D status, bone metabolism, welfare and birth progress of gestating and lactating sows, forty-nine multiparous sows were randomly assigned to one of two diets: “CON” (n = 25; 50 μg vitamin D3/kg feed) and “HYD” (n = 24; 50 μg 25-hydroxycholecalciferol/kg feed). The basal diets were protein- and phosphorus-reduced. The trial started on day 3 ante insemination of the sows and ended with weaning of the piglets on day 28 postpartum. Dietary supplementation of 25-hydroxycholecalciferol resulted in improved maternal vitamin D status (p < 0.001), fewer gait changes (p < 0.01) and longer standing time after feeding (day 5 ante partum; p < 0.05) compared to vitamin D3. However, the bone markers CrossLaps and osteocalcin were not affected. Overall, the present results suggest that sows fed 25-hydroxycholecalciferol instead of vitamin D3 showed improved locomotion and stance strength. However, this outcome is probably not related to altered bone metabolism. The underlying mechanisms must be investigated in further studies.
Duckweeds can be potentially used in human and animal nutrition, biotechnology or wastewater treatment. To cultivate large quantities of a defined product quality, a standardized production process is needed. A small-scale, re-circulating indoor vertical farm (IVF) with artificial lighting and a nutrient control and dosing system was used for this purpose. The influence of different light intensities (50, 100 and 150 µmol m−2 s−1) and spectral distributions (red/blue ratios: 70/30, 50/50 and 30/70%) on relative growth rate (RGR), crude protein content (CPC), relative protein yield (RPY) and chlorophyll a of the duckweed species Lemna minor and Wolffiella hyalina were investigated. Increasing light intensity increased RGR (by 67% and 76%) and RPY (by 50% and 89%) and decreased chlorophyll a (by 27% and 32%) for L. minor and W. hyalina, respectively. The spectral distributions had no significant impact on any investigated parameter. Wolffiella hyalina achieved higher values in all investigated parameters compared to L. minor. This investigation proved the successful cultivation of duckweed in a small-scale, re-circulating IVF with artificial lighting.
Duckweeds are fast-growing and nutritious plants, which are gaining increased attention in different fields of application. Especially for animal nutrition, alternative protein sources are needed to substitute soybean meal. The current bottleneck is the standardized production of biomass, which yields stable quantities of a defined product quality. To solve this problem, an indoor vertical farm (IVF) for duckweed biomass production was developed. It consists of nine vertically stacked basins with a total production area of 25.5 m2. The nutrient solution, a modified N-medium, re-circulated within the IVF with a maximum flow rate of 10 L min−1. Nutrients were automatically added based on electrical conductivity. In contrast, ammonium was continuously supplied. A water temperature of 23 °C and a light intensity of 105 μmol m−2 s−1 with a photoperiod of 12:12 h were applied. During a 40-day production phase, a total of 35.6 kg of fresh duckweed biomass (equals 2.1 kg of dried product) was harvested from the IVF. On average, 0.9 kg day−1 of fresh biomass was produced. The dried product contained 32% crude protein (CP) and high levels of proteinogenic amino acids (e.g. lysine: 5.42 g, threonine: 3.85 g and leucine: 7.59 g/100 g CP). Biomass of this quality could be used as a protein feed alternative to soybean meal. The described IVF represents a modular model system for duckweed biomass production in a controlled environment and further innovations and upscaling processes.
Dieser Artikel befasst sich mit dem bundesweiten Niveau der Treibhausgas (THG)-Emissionen und des Ressourcenverbrauchs in der deutschen Gemeinschaftsverpflegung im Segment "Business" und deren Einsparpotenziale durch verschiedene Szenarien der ungestützten und gestützten Rezeptüberarbeitung. Unter "ungestützt" verstehen wir in dieser Arbeit die intuitive Optimierung von Rezepten durch die Mitarbeiter von Betrieben der Gemeinschaftsverpflegung. Die "unterstützten" Ansätze mussten dagegen bestimmte Zielvorgaben erfüllen, zum Beispiel der Deutschen Gesellschaft für Ernährung; engl. Deutschen Gesellschaft für Ernährung oder das nachhaltige Niveau. Konkret Konkret wird getestet, wie sich (A) eine ungestützte Rezeptüberarbeitung, (B) eine Rezeptüberarbeitung auf Basis von Ernährungsempfehlungen und (C) eine Rezeptüberarbeitung mit wissenschaftlicher Begleitung die Umweltauswirkungen eines Gerichtes beeinflussen. Als methodischer Rahmen diente eine Online-Befragung von Unternehmen der Gemeinschaftsverpflegung sowie eine Szenarioanalyse auf Menüebene und auf nationaler Ebene durchgeführt. Die Ergebnisse basieren zum einen auf empirischen Daten und zum anderen auf Hochrechnungen. Die Ergebnisse zeigen, dass die die bundesweite Umsetzung der Rezepturüberarbeitung nach wissenschaftlichen Vorgaben - wie konkrete Zielvorgaben für die THG Emissionen pro Portion - bis zu 44% des Ressourcenverbrauchs in der deutschen Betriebsgastronomie einsparen kann (das entspricht 3,4 Millionen Tonnen Ressourcen pro Jahr) und bis zu 40 % der THG-Emissionen (0,6 Millionen Tonnen THG-Emissionen pro Jahr) einsparen.
Die Verschwendung von Lebensmitteln im Haushalt wird durch eine komplexe Reihe von routinemäßigen Verhaltensweisen bestimmt, und eine Unterbrechung dieser Routinen könnte zu einer Verringerung dieser enormen Menge an Lebensmittelabfällen führen. In der vorliegenden Studie wird eine solche Unterbrechung der Haushaltsroutinen untersucht: die Essensbox.
Das Potenzial von Essensboxen zur Verringerung verschiedener Arten von Lebensmittelabfällen in Haushalten wird zum ersten Mal in verschiedenen Ländern untersucht. Nachdem wir einen Rahmen für den Vergleich der Auswirkungen verschiedener Mahlzeitentypen auf die Lebensmittelverschwendung geschaffen haben, untersuchen wir anschließend die Auswirkungen einer abonnementbasierten Lebensmittelversorgung (d. h. Mahlzeitendosen) auf die gesamte Lebensmittelverschwendung sowie auf die verschiedenen Arten der Lebensmittelverschwendung: Zubereitung, Kochen und Tellerabfälle. Unser Datensatz enthält 8747 Beobachtungen von Mahlzeiten aus 955 Haushalten in sechs Ländern. Die Ergebnisse eines Bayes'schen Mehrebenen-Hurdle-Lognormal-Modells mit zufälligem Intercept zeigen, dass Essensboxen im Vergleich zu traditionell gekochten Mahlzeiten insgesamt zu einer Verringerung der gesamten Essensabfälle führen (38 % weniger). Mahlzeitendosen verringern vor allem das Auftreten und die Menge der verschwendeten Pfannen- und Topfgerichte (d. h. Kochabfälle) sowie die Menge der Mahlzeitenzubereitungsabfälle, führen jedoch im Vergleich zu herkömmlichen Mahlzeiten zu einem höheren Aufkommen von Zubereitungs- und Tellerabfällen. Dies zeigt, wie sich die Unterschiede zwischen den einzelnen Mahlzeiten auf die Lebensmittelabfälle in den Haushalten auswirken, ein Aspekt, der bisher in der Forschung wenig Beachtung gefunden hat. Während sich die meisten früheren Untersuchungen auf die gesamte Lebensmittelverschwendung in Haushalten konzentrierten, zeigt unsere Studie, dass die Unterscheidung zwischen verschiedenen Arten von Lebensmittelabfällen in Haushalten wichtige neue Erkenntnisse liefern kann.
Information systems (IS) play a central role in promoting corporate sustainability and pro-environmental behavior. This study explores the use of mobile apps for fostering sustainability-oriented corporate culture. It accentuates issues relating to sustainability-oriented corporate culture (RQ1), app meta-requirements as a strategic approach to addressing these issues (RQ2), as well as design and implementation principles (RQ3). Referring to the literature on sustainability apps, gamification, and nudging, our qualitative research design combines an analysis of four corporate apps intending to promote sustainable behavior and expert interviews (Grounded Theory). The proposed framework supports the planning, realization, and monitoring of this targeted app use. Single cultural dimensions inform seven issues in culture development. Five meta-requirements address this multi-dimensionality, challenges provided by new digital working environments, and principles of Green IT. Four design principles support, extend, and integrate current knowledge on app features, nudging, and gamification. Five variables determine the app intervention and maturity level. We conclude that this targeted app use should intend to foster the sustainability orientation within all dimensions of corporate culture instead of being limited to promoting sustainable behavior.
Oleamide is used as a lubricant in the manufacturing and application of polypropylene (PP) medical devices. Samples of PP were prepared with 0, 1500, and 15 000 ppm oleamide content as lubricant. The samples were either left non-sterile, sterilized with ethylene oxide (ETO), γ-radiation (γ) or autoclaved (A) and stored for up to 4 weeks. To determine the oleamide bulk-to-surface distribution depending on sterilization method and storage time an extraction method and a washing technique were applied. The oleamide content was determined by gas chromatography (GC-FID) and compared with the coefficient of friction (COF). The COF dependent on the measured lubricant content at the surface. The content of lubricant on the surface depends on the type of sterilization: ETO increased the lubricant content to some extent, γ-sterilization and autoclaving reduced it. After storage, no migration of the lubricant to the surface could be detected.
rationale: Musculoskeletal problems are widespread in performing artists and are due to the special demands of instrument playing, singing or dancing. Additionally, various other factors might contribute to performance-related musculoskeletal problems. In order to provide a specific physiotherapeutic management for performing artists, it is important to gain information about the performing art, the individual (biomechanical) demands and contributing factors. The subjective examination is the basis of the clinical reasoning process and the hypothesis forming, which is important for goal setting in further clinical examination and biomechanical analysis. In the present protocol, the subjective examination consists of a questionnaire based section and an interview based section and is part of the evaluation process of the neuromusculoskeletal examination of a performing artist specific reference laboratory.
purpose: The aim of this study was to develop a standardized protocol for an interview based subjective examination of performing artists with musculoskeletal problems. The results of this section of the subjective examination will be combined with the results of the questionnaire based subjective examination , in order to gather as much relevant information as possible to specifically address the individual’s musculoskeletal health status.
methods: A common physiotherapeutic recording of findings which addresses the relevant questions of the subjective examination of musculoskeletal problems was used. In order to adapt the anamnesis to performing-related musculoskeletal problems, questions specific to instrument playing, singing and dancing were selected on the basis of a literature search and the expertise of the research group.
results: The protocol is based on the five aspects of clinical practice described by Maitland and the Musculoskeletal Clinical Translation Framework by Mitchell et al. (2017) .The performing art specific questions especially address (1) performing art specific considerations including style, genre, education and professional level, practice habits, repertoire, and external factors, e.g. concert conditions, (2) performing art specific physical and psychosocial contributing factors, and (3) performing art specific activities which trigger the musculoskeletal problems and help to form hypotheses for the following clinical examination. Individual tracks lead through the subjective examination so that irrelevant questions are skipped depending on the kind of musculoskeletal problem and the performing art practiced by the individual client.
conclusions: A pretest of this standardized anamnesis protocol is ongoing in a special physiotherapy clinic for performing artists since spring 2022. In an iterative approach, the protocol will be continuously improved based on patient feedback and clinical considerations.
Hintergrund
Negatives Geburtserleben steht im Verdacht mit nachfolgender Sterilität, einem längeren Abstand zum nächsten Kind, sowie dem Wunsch nach einer primären Sectio bei einer weiteren Schwangerschaft assoziiert zu sein. Die derzeitige Datenlage ist kontrovers.
Methodisches Vorgehen
Das Design entspricht einer explorativen, qualitativen Querschnittsstudie. Dazu wurden zehn leitfadengestützte Interviews nach dem Prinzip des Problemzentrierten Interviews durchgeführt. Eingeschlossen wurden Primiparae, die vor dem 11.03.2020 (vor den Einschränkungen der Covid-19-Pandemie) geboren haben. Die Interviews wurden nach der inhaltlich strukturierenden qualitativen Inhaltsanalyse nach Kuckartz analysiert.
Ergebnisse
Insbesondere Frauen mit negativem Geburtserleben tendieren zu einer abgeschwächten Bereitschaft für eine weitere Schwangerschaft, dazu keine weitere Schwangerschaft zu planen sowie einen längeren Abstand zu einer weiteren Schwangerschaft zu wahren. Nur in Einzelfällen kann bei Frauen mit positiver Geburtserfahrung eine verstärkte Bereitschaft für eine weitere Schwangerschaft festgestellt werden. Die Entscheidung bezüglich der Planung einer Schwangerschaft ist multifaktoriell und sowohl vom Geburtserleben als auch von persönlichen, medizinischen, familiären und finanziellen Aspekten abhängig.
Diskussion
Besonders das Auftreten medizinischer Besonderheiten, das negative Erleben des Geburtsmodus, der peripartalen Schmerzen sowie der Betreuung und Versorgung scheinen Einflussfaktoren zu sein, welche die Bereitschaft für die Planung einer weiteren Schwangerschaft abschwächen. Es besteht weiterer Forschungsbedarf durch quantitative Arbeiten und in der Begriffsdefinition von Geburtserleben.
Fazit
Das individuelle Geburtserleben von Primiparae kann einen Einfluss auf die Planung einer weiteren Schwangerschaft haben.
Background
Spinach is a nitrogen (N) demanding crop with a weekly N uptake of up to 60 kg ha–1. Consequently, a high N supply is required, which can temporarily lead to high quantities of nitrate (NO3–) being at risk of leaching.
Aims
The objective of this study was to develop a N fertilization approach to reduce the risk of NO3– leaching in field-grown spinach production without adversely affecting crop yield and quality at an early and late harvest stage.
Methods
Ten fertilization trials were conducted to compare different base fertilization rates and splits of top dressings. For top dressings, granulated fertilizers or foliar sprays were used. In a further treatment, N supply was reduced by withholding the second top dressing of 50–70 kg ha−1.
Results
Nitrate concentration at risk of leaching was considerably reduced by decreasing the base fertilizer rate as well as by splitting the top dressing. However, at an early harvest stage, total aboveground dry mass was reduced by, on average, 6% by these measures across all seasons. In contrast, at a later harvest stage, spinach was less affected by the fertilizer schedule. Urea foliar sprays proved to be insufficient in promoting plant growth and caused leaf necrosis. A reduced N supply led to impaired plant growth and yellowish leaves in both spring and winter.
Conclusions
Base N fertilization of spinach is only required in spring, but not in other seasons. Despite slight yield reduction, the top dressing should be split to reduce the risk of NO3− leaching after an early harvest.
Currently, soil nutrient analysis involves two separate processes for soil sampling and nutrient analysis: 1. field soil sampling and 2. laboratory analysis. These two - separate - main work processes are combined and conceptualised for a mobile field laboratory so that soil sampling and analysis can be carried out simultaneously in the field. The module-based field laboratory "soil2data" can carry out these two main work processes in parallel and consists of 5 different task-specific modules that build on each other: app2field, field2soil, app2liquid, liquid2data and data2app. The individual modules were designed and built for the sub-process steps and adapted to the special features of the mobile field laboratory "soil2data". The biggest advantage is that the analysis results are available immediately, and a fertiliser recommendation can be generated instantly. For further analyses, the results are stored in the data cloud. The soil material remains in the field. In the ongoing project "Prototypes4soil2data", the mobile field laboratory soil2data is being further developed into a prototype with a modular structure.
Der Beitrag analysiert den Umgang mit der Covid-19-Pandemie innerhalb der Krankenhäuser und leitet davon Handlungsempfehlungen für das Krankenhausmanagement ab. Dabei geht es sowohl um die Organisation und Ausgestaltung der Patienten- und Personalsteuerung (vorgelagerte Notaufnahmen, Aufnahmestationen, Triage, Covid-19-Testung etc.) als auch um die sich durch die Kontaktbeschränkung ergebene Herausforderung im Umgang mit Besuchern und Lieferanten. Des Weiteren wird auch die betriebswirtschaftliche Steuerung in einer – in allen Belangen – ungewohnten Situation beleuchtet.
Knowledge of the small-scale nutrient status of a field is an important basis for decision-making when it comes to optimising the fertiliser use in crop production. Currently, the traditional method involves soil sampling in the field and soil sample analysis in the laboratory as two separate working processes.
The previous research project "soil2data" developed a mobile field laboratory for different carrier vehicles. In the follow-up project "prototypes4soil2data", the results of soil2data are further developed. A mixed soil sample is collected during the drive on the field. The soil sample is then wet-chemically prepared and analysed. The overall soil sampling and analysis process is divided into the following process steps: soil sampling planning, soil sampling, soil preparation, soil analysis and data management. The process steps are modified for the mobile field laboratory and the process steps run in parallel. The new soil extraction method is based on official German methods (VDLUFA) to ensure the interoperability of the analysis results with the VDLUFA fertiliser recommendations. An innovative key component is the NUTRISTAT analysis module (lab-on-chip with ISFET measurement technology). It can measure pH, the nutrients NO3-, H2PO4-, K+ and the electrical conductivity. In addition to the advantages of rapid data availability and no need to transport soil material to the laboratory, it provides a future basis for new application, e.g. verification of current results in the field during soil sampling with existing results or dynamic adjustment of soil sampling during work in the field.
Aufgrund der Folgen des Klimawandels bekommen klimaanpassende Maßnahmen immer mehr Bedeutung. Durch versiegelte Flächen und Starkregen können einerseits Überschwemmungen entstehen, anderseits führen Hitze und wenig Niederschlag zu Trockenheit und Wassermangel. Deswegen ist es wichtig, klimaanpassende Maßnahmen zu fördern und diese den Bürgern näher zu bringen.
Das Ziel dieser Bachelorarbeit ist, eine Webanwendung zu entwickeln, die die Bürger zur Nutzung von Regenwasser und zu Entsiegelungen als klimaanpassende Maßnahmen motiviert, indem Nutzern eine individuelle Berechnung der Kosten und des Nutzens angeboten wird. Dafür folgt die Entwicklung der Webanwendung dem menschzentrierten Gestaltungsprozess, um eine hohe Benutzerfreundlichkeit zu erreichen. Es werden Usability-Tests als Evaluation durchgeführt.
Die Ergebnisse der Evaluation zeigen, dass die entwickelte Webanwendung die Nutzer zufriedenstellt und die Anforderungen erfüllt. Der menschzentrierte Gestaltungsprozess ist für das betrachtete Themenfeld ein wirksames und zielführendes Vorgehen bei der Entwicklung interaktiver Systeme.
Flexibility in planning through frequent amendments. The practice of land use planning in Germany
(2022)
How can formal planning deal with uncertainty and rapid change while maintaining high standards of procedural certainty? This paper, using Germany as an example, examines how municipalities handle this dilemma within their existing planning systems. Municipalities use different approaches, ranging from regular redrafting to comprehensive changes or regular amendments. Amendments and complementary informal plans are important components of flexibility in planning. We argue that the choice to make frequent amendments instead of redrafting the preparatory land-use plan does not necessarily lead to a loss of a city-wide, long-term perspective, provided amendments are prepared and justified using informal concepts.
Die vorliegende Arbeit befasst sich mit ausgewählten, pädagogischen Werken der französischen Komponistin Mélanie Hélène Bonis (1858-1937). In der Hauptsache soll es dabei um eine systematische Einordnung in die, durch Anselm Ernst formulierten didaktischen Lernfelder gehen. Anhand historischer sowie aktueller Lehrpläne und Technikschulen für Tasteninstrumente soll die Frage nach didaktischen Qualitäten gestellt und vergleichend beantwortet werden. Hierfür sind drei Sammelbände mit Klavierliteratur der Unter- bis Mittelstufe entsprechend beschrieben, analysiert und ausgewertet worden. Es wird sich zeigen, dass die Kompositionen Mélanie Hélène Bonis‘ sowohl didaktischen Ansprüchen genügen, als auch eine Bereicherung musikalisch-kreativer Lernprozesse darstellen.
Freshwater ecosystems host disproportionately high numbers of species relative to their surface area yet are poorly protected globally. We used data on the distribution of 1631 species of aquatic plant, mollusc, odonate and fish in 18,816 river and lake catchments in Europe to establish spatial conservation priorities based on the occurrence of threatened, rangerestricted and endemic species using the Marxan systematic conservation planning tool. We found that priorities were highest for rivers and ancient lakes in S Europe, large rivers and lakes in E and N Europe, smaller lakes in NW Europe and karst/limestone areas in the Balkans, S France and central Europe. The a priori inclusion of well-protected catchments resulted in geographically more balanced priorities and better coverage of threatened (critically endangered, endangered and vulnerable) species. The a priori exclusion of well-protected catchments showed that priority areas that need further conservation interventions are in S and E Europe. We developed three ways to evaluate the correspondence between conservation priority and current protection by assessing whether a cathment has more (or less) priority given its protection level relative to all other catchments. Each method found that priority relative to protection was high in S and E Europe and generally low in NW Europe. The inclusion of hydrological connectivity had little influence on these patterns but decreased the coverage of threatened species, indicating a trade-off between connectivity and conservation of threatened species. Our results suggest that catchments in S and E Europe need urgent conservation attention (protected areas, restoration, management, species protection) in the face of imminent threats such as river regulation, dam construction, hydropower development and climate change. Our study presents continental-scale conservation priorities for freshwater ecosystems in ecologically meaningful planning units and will thus be important in freshwater biodiversity conservation policy and practice, and water management in Europe.
The production of food-grade substances and complex biocatalysts used as additives or active ingredients – mainly for food applications – can be achieved in the eukaryotic expression system of Aspergillus niger. Food proteins or food enzymes e.g., casein, ovalbumin, phytase or glucoamylase are highly complex polymers. Most of them could be used as nitrogen or energy source for animals and humans, while others are industrial relevant biomass-degrading enzymes used for biological waste processing and food production.
However, the successful production of novel recombinant proteins can be challenging, resource- and time consuming. Therefore, A. niger mutant libraries are needed to understand the “adjusting screws” to produce high yields of recombinant proteins, preferably even in a kind of generic, transferable system. In order to establish a universal and multipurpose expression platform, there is the need to overcome the lack of high throughput assays first.
To tackle this problem, we designed a modular, quantitative and feasible high-throughput screening system to express and screen recombinant proteins regarding their stability and functionality in A. niger. For this purpose a dual-luciferase reporter gene system, which is applicable in small scale will be established for A. niger. After the generation of an A. niger secretion mutant library, the system will be transferred and tested to other proteins of interest. The technology can be integrated into bio-regenerative life support systems for the autonomous production of e.g., food, food additives and food enzymes on earth as well as in deep-space.
Hintergrund: In Deutschland beginnen 96,6% der Frauen nach der Geburt ihr Kind zu stillen, nach den ersten vier Lebensmonate werden jedoch nur 55,8% der Neugeborenen ausschließlich gestillt (vgl. Kersting et al. 2020). Viele Mütter überwinden trotz hoher Stillmotivation die ersten Stillschwierigkeiten bei der Etablierung des Stillens nicht (vgl. Rasenack et al. 2012; Weissenborn et al. 2016). Es besteht also Forschungsbedarf, wie Mütter Stillschwierigkeiten erleben und überwinden, um zu ergründen, wie sie beim Stillen unterstützt werden können.
Zielsetzung & Methodik: Zur Beantwortung der Forschungsfrage „Wie werden Stillschwierigkeiten aus der Perspektive von erststillenden Müttern erlebt und bewältigt?“ wurde ein qualitativer Forschungsansatz gewählt. Über das Projekt „Stillförderung im Landkreis und der Stadt Osnabrück“ konnten 11 Frauen für ein halbstrukturiertes, problemzentriertes Interview nach Witzel gewonnen werden. Die Mütter wurden einzeln und retrospektiv 4 - 11 Monate nach der Geburt befragt. Ausgewertet wurden die erhobenen Daten wurden mit der qualitativen Inhaltsanalyse nach Mayring.
Ergebnisse: Das Erleben von Stillschwierigkeiten ist ein sehr emotionales und komplexes, teils widersprüchlich empfundenes Thema. Sie geht einher mit der Erfahrung nicht erfüllter Erwartungen, extremer Schmerzen und dem Aufkommen von teils konträren Gefühlen. Die Still- und Ernährungssituation des Kindes bestimmen den Alltag und werden als zeitaufwändig und unpraktisch erlebt. Beim Erreichen der emotionalen Belastungsgrenze machen sich Mütter Gedanken über das Abstillen. An diesem Punkt empfinden sie eine große Diskrepanz zwischen der eigenen hohen Stillmotivation und der selbst erlebten Stillunfähigkeit. Für die Bewältigung von Stillschwierigkeiten spielen eine hohe Stillmotivation und bestimmte Charaktereigenschaften wie Durchhaltevermögen eine wichtige Rolle. Mütter wenden in der Stillsituation verschiedene Bewältigungsstrategien an, um proaktiv und lösungsorientiert mit dieser umgehen zu können. Schmerzen werden ertragen und negative Gefühle überwunden durch eine innere Distanzierung.
Fazit: Die erhobenen Ergebnisse werden durch bereits vorhandene Studien belegt. Aus den Ergebnissen lassen sich konkrete Handlungsempfehlungen für Stillberatungen ableiten.
Background
The aim of this qualitative study was to identify a practice level model that could explain a sustained change in nutritional behavior.
Methods
The study used three data inputs from four interviewees, one merged input from a married couple, as narrative interviews. The interviews were analyzed using grounded theory.
Results
Coexistence of a certain suffering and a triggering episode lead to the decision to change nutritional life-style by all interviewed. Maintenance of the self-determined newly learned nutritional behavior was supported by subject-related intrinsic motivation, the ability to reflect, and a low expectation of success from the behavioral change. Environment-related factors were identified as support from life-partner and peers. Subjects reported that the sustained nutritional behavior change impacted their holistic health through subject-perceived improved life quality, increase in the number of social contacts, and a change in personal attitudes and perception. The analysis remains limited, and at best hypothesis generating, in that only three data inputs from four interviewees were used.
Conclusion
In this hypothesis-generating narrative interview study of four study subjects, volition, personal decision making, and long-term motivation (though not external determination) seemed to sustain a change in newly learned nutritional behavior.
Adventitious root (AR) formation is the basis of vegetative propagation in rose, be it via stem cuttings or via stenting. During this process, wounding plays a pivotal role since cell reprogramming takes place at the tissue adjacent to the wound. We investigated the effects of wounding on AR formation on leafy single-node stem cuttings of the rose rootstock R. canina ‘Pfänder’ (codes R02-3 and R02-6) and the cut rose cultivar Rosa ‘Tan09283’ (Registration name ‘Beluga’). Laser wounding treatments were based on the assisted removal of tissue layers located in the bark. The positioning of wounding was studied based on two marking directions: along the cutting base (strip pattern) and around the cutting base (ring pattern). Additionally, the effects of external supply of indole-butyric acid (IBA 1 mg L-1) on rootingwere analyzed. Results showedthat inorder toremovespecific tissue layers, the calculation of the laser energy density (J cm-2) in terms of cutting diameter was necessary. Interestingly, the application of energy densities from 2.5 J cm-2 up to approximately 8.5 J cm-2 were sufficient to expose the tissue layers of epidermis up to regions of phloem. Regarding AR formation for R. canina ‘Pfänder’, characterized by a low rooting response, an increase in the rooting percentage was registered when the laser treatment eliminated the tissue up to phloem proximities. Analysis of the nodal position showed that bud location was a preferential place for AR formation independently of wounding treatment. In case of Rosa ‘Tan09283’, laser treatments did not reduce its high rooting capacity, but an apparent reduction in rooting quality due to an investment in tissue healing was observed when wounding reached deeper layers such as parenchyma and sclerenchyma. Results also showeda strongARformation directly fromwounded regions in case of Rosa ‘Tan09283’ specifically when the woundwas located below the axillary bud. In conclusion, wounding by assisted-elimination of layers by laser can induce positive effects on AR formation of single-node stemcuttings of the rose if energy applied is able to expose phloemproximities,a longitudinalorientation, and relative position to the axillary bud are considered.
Der Ökologische Landbau hat als Ziel die Biodiversität, die vor allem durch die Flora beeinflusst wird, zu stärken. In Verbindung mit dem Ertragsziel der landwirtschaftlichen Produktion ergibt sich dadurch die Frage, mit welchen Maßnahmen sowohl eine höhere Beikrautbiodiversität als auch die Ertragssicherung kombiniert werden können.
Hierzu wurde in der Nähe von Osnabrück ein einjähriger Versuch mit ökologisch angebauter Wintertriticale angelegt. Der Versuch wurde als Split-Plot-Design mit 4 Blöcken und Variationen von Saattermin, Saatstärke und mechanischer Beikrautregulierung an zwei Terminen im Frühjahr, auch mit Hackvarianten in 25 cm Reihenabstand, angelegt und von März 2022 bis zur Ernte im Juli 2022 regelmäßig auf vegetative und später auch generative Triticaleparameter sowie auf das Auftreten verschiedener Beikrautarten und den Beikrautdeckungsgrad geprüft.
Durch den frühen Saattermin am 18.10.2021 konnte verglichen mit dem späten Saattermin am 01.11.2021 aufgrund der längeren Wachstumsphase ein erhöhtes vegetatives Wachstum der Triticale erreicht werden. Ebenso wurde die Zahl der Beikrautindividuen und -arten gefördert, da sich insbesondere Herbstkeimer durch die zeitige Aussaat besser etablieren konnten. Eine erhöhte Konkurrenzwirkung konnte aufgrund von indifferentem Beikrautdeckungsgrad und gleichbleibender Beikrautbiomasse nicht festgestellt werden. Der Kornertrag wurde nicht beeinflusst, aber der Proteingehalt stieg um etwa 0,5 Prozentpunkte an. Entsprechend kann geschlussfolgert werden, dass die Beikrautbiodiversität durch die frühere Aussaat gefördert wurde, während der Strohertrag stieg, der Kornertrag gleichblieb und der Proteingehalt marginal sank.
Die erhöhte Saatstärke führte wie zu erwarten zu einer höheren Bestandesdichte, die auch zu einem höheren Kulturdeckungsgrad führte. Die daraus resultierende höhere Konkurrenzkraft der Triticale führte zu weniger Beikrautbiomasse und weniger Beikrautindividuen sowie -arten. Allerdings konnte in puncto Kornertrag kein Einfluss der Saatstärke festgestellt werden, da die höhere Ährendichte bei höherer Saatstärke durch das Ährengewicht ausgeglichen wurde. Der Proteingehalt stieg sogar durch die reduzierte Saatstärke. Entsprechend kann die reduzierte Aussaatstärke empfohlen werden, da sie positiv für die Beikräuter, indifferent für Stroh- und Kornertrag und positiv für den Proteingehalt eingeschätzt wird. Darüber hinaus können Saatgutkosten eingespart werden.
Den stärksten Einfluss auf Beikräuter und Triticale hatte allerdings die mechanische Beikrautregulierung. Das vegetative und generative Wachstum der einfachen Hackvariante in 25 cm Reihenabstand hat im Vergleich zur Striegelvariante deutliche Vorteile gezeigt. Auch der Proteingehalt und -ertrag konnte erhöht werden. Die intensive Hackvariante mit zusätzlichem Einsatz einer Rotary Hoe verhielt sich intermediär, da sie vermutlich die Kulturpflanze geschädigt hat.
Dagegen wies die Striegelvariante im Vergleich zur intensiven Hackvariante die höchste Zahl an Beikrautarten auf, während allerdings auch Beikrautdeckungsgrad, -biomasse und -individuenzahl maximal waren. Die intensive Hackvariante wies dagegen das ausgeglichenste Beikrautartenverhältnis auf (geringe Dominanz, hohes SDI). Bezüglich der Beikrautparameter verhielt sich die normale Hackvariante intermediär. Bei der normalen Hackvariante konnten entsprechend sämtliche Ertragsparameter maximiert werden, während sich die Beikrautparameter nicht signifikant veränderten. Die Beikrautvielfalt und -abundanz tendierte zu sinken, während die Ausgeglichenheit der Beikrautarten zunahm und entsprechend dominante Arten, wie Acker-Frauenmantel (Aphanes arvensis L.) an Bedeutung verloren haben, was eine Zönose vorbeugt.
Background:
Neck pain is one of the most common musculoskeletal pains and among the fourth leading causes of years of life lost due to disability, following back pain, depression, and arthralgia. (1)
In the course of their lives, about 70% of all people will experience a clinically relevant episode of neck pain, (2) so finding a good therapy to treat it is of high interest. Aerobic exercise is associated with pain reduction in patients with different types of MSK pain. Recent studies have shown a positive impact of aerobic exercises on brain function, memory processing, cognition, and motor function. (3, 4)
Therefore, the influence of aerobic exercise on pain modulation seems to be of particular interest for individuals with chronic MSK pain, since brain imaging studies have shown that these patients have structural and functional changes, as well as abnormal brain features in various areas of the brain. The evidence regarding the effectiveness of aerobic exercise for neck pain seems limited and outdated.
Thus, a systematic review evaluating the effects of aerobic exercise in patients with neck pain is needed. Therefore, this review aims to investigate the effectiveness of aerobic exercise interventions when compared to other conservative and non-conservative interventions (e.g., localized exercises, medication, acupuncture, physical agents, manual therapy) to decrease pain intensity in people with neck pain.
Materials and methods:
Electronic literature searches were conducted in a total of six databases such as Medline, Embase, CINAHL, Cochrane Library, Web of Science, and Scopus. The review considered randomised controlled trials (RCTs) including patients over 18 years having musculoskeletal pain in the neck area. The Neck Pain Task Force's classification of pain severity describes four levels of neck pain, with the first three levels considered in this review. (5)These must be clinically diagnosed by a health care provider according to signs and symptoms or based on standardized criteria specific for each disease. Studies involving subjects with any pre-existing conditions, previous surgery, or pain not clearly related to the musculoskeletal system were excluded. No limits were applied in terms of sex, ethnicity, and living country. Data were extracted using a standardized data extraction form.
Methodological quality was determined using the Cochrane Collaboration Risk of Bias Tool (CCRBT) and the strength of the evidence with Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Data were extracted and evaluated by two independent reviewers.
Results:
A total of 21585 records were identified and screened independently for eligibility by two reviewers. A total of six unique studies, reported on ten manuscripts met the specified inclusion criteria. Different types of aerobic exercise were used in the studies. Studies included isolated and combined aerobic exercise using interventions such as cycling on an ergometer or walking outdoors at a moderate intensity. Comparison groups were for example strength training or education. The most common outcome was pain assessed with the Visual Analogue Scale (VAS) or the Nordic questionnaire.
The included studies had a high risk of bias and the overall quality of the evidence for this systematic review was considered low. There was high heterogeneity in the included studies regarding interventions applied and study results.
When looking at the effect of aerobic exercise versus control group or other intervention groups measured with VAS, it can be observed, that there was a great heterogeneity between studies results (different magnitudes and directions). Although none of the comparisons showed a statistically significant difference between aerobic exercise and control (MD 6.24 mm, 95% CI [-11.21; 23.96]) or active intervention groups (MD -9.52 mm, 95% CI [-18.48; -0.56]) on pain intensity; it seems that aerobic exercise is slightly better than a control group, and equally effective as other active treatments such as strength exercise or education.
In addition, when combined with other therapeutic modalities, aerobic exercise, could potentially help to reduce pain intensity (MD 7.71 mm, 95% CI [1.07; 14.35]). Especially in the long term, the combination of strength and aerobic exercise showed promising results. Statistically significant differences in favour of aerobic exercise for pre vs. three months follow up (MD 11.20 mm, 95% CI [2.85;19.55]) and pre vs. six moths follow up (MD 15.10 mm, 95% CI [6.99; 23.21]) were found.
Conclusions:
Although there is currently limited evidence on the effectiveness of aerobic exercise in individuals with chronic neck pain, aerobic exercise was found to not only reduce pain intensity, but also to improve disability as well as physical and emotional functioning. However, as the evidence is limited, low quality, and heterogeneous, further research is needed in this area to obtain more accurate results.
Das Business Model Canvas erfreut sich in der Praxis großer Beliebtheit. Esunterstützt bei der Entwicklung von innovativen Geschäftsmodellen beiNeugründung, kann aber auch zur Evaluation bestehender Geschäftsmodelleeingesetzt werden. Durch das Business Model Canvas ist esmöglich, dieSchlüsselfaktoren eines Geschäftsmodells auf intuitive Weise strukturiert zuvisualisieren. Der vorliegende Beitrag erläutert das Business Model Canvasund nimmt eine kritische Würdigung vor.
Who is more eager to use Gamification in Economic Disciplines? Comparison of Students and Educators
(2022)
Background: In this paper, the focus is on the application of digital and mobile technologies as supporting tools for the implementation of gamification in the field of education of future economists. Objectives: The paper's main objective is to explore whether educators and students are motivated and willing to apply additional technologies as main gamification components in their work and education. Moreover, the paper aims to assess how their more comprehensive application affects the quality of teaching, work flexibility, new learning opportunities, and outcomes. Methods/Approach: The survey method was used to collect answers from educators and students primarily interested in accounting, finance, trade and tourism from higher and secondary education institutions in Croatia, Poland, Serbia and Germany. Afterwards, the responses were compared using statistical methods. Results: Research results confirm that educators and students are willing to use gamification in teaching. Still, they also expressed the need for better administrative support in using particular e-learning tools. Surprisingly, educators are more eager to use gamification in their work than students. Conclusions: The study's general conclusion is that educators and students are both aware of the advantages of using e-learning tools provided through digital and mobile technologies and are eager to implement more gamification in the teaching process. However, continuous education in applying new digital technologies is needed on both sides.
Technological support options for the usage of Brazilian Açaí berries in the European Food Market
(2022)
The highly perishable fruit açaí grows on palm trees in northern Brazil and is colloquially known as a berry with high nutritional value. The seed of the drupe makes up around 85 percent of the fruits weight and only the pulp around the seed is used for human consumption. The manufacturing step after harvest includes the pulping and the preservation of the fruit. The preservation step is necessary, because the açaí pulp contains a high microbial load. There are several preservation processes including the use of chlorinated or ozonated water, alcoholic fermentation, pasteurization, freezing or dehydration. Those techniques are overall not very gentle and have the potential to leave residues in the final product, which can change its typical sensorial characteristics. Therefore, an experiment was conducted, to see if a relatively new gentle preservation method called PEF can reduce the microbial load in an açaí- smoothie.
For this purpose, a PEF-machine was built and verified based on the paper from HEINZ ET AL. [2003]. The self-built machine works efficiently, when there is a reduction of microorganisms like Escherichia coli in apple juice due to the induced Pulsed Electric Fields. If this is the case, the described experiment with açaí-smoothie can be carried out with the self-built PEF- machine. In this experiment the results of the validation of this PEF-machine were not comparable to those from the paper from HEINZ ET AL. [2003]. So, the self-built PEF-machine in Brazil did not work sufficiently. Hence, the experiment which should show that a reduction of microorganisms, such as Escherichia coli, in açaí-smoothie with PEF is possible, was performed in Germany. It was accrued out at ELEA with using the PEFPilotTM Dual. This experiment confirmed the assumption, that microorganisms can be reduced in açaí-smoothie with PEF. Escherichia coli was reduced by 2 logs, Saccharomyces cerevisiae by 3 logs and Lactobacillus plantarum by 6 logs. And a comparison between PEF and the known preservation methods for açaí showed that it can be a compatible alternative.
Moreover, the topic, how açaí fits into the European Food Market is answered within this paper. When offering açaí food products to the European population, ideas can be originated from the well-working Brazilian market. It can be helpful to mix açaí with known European fruits for a better acceptance by the people. Then açaí can help to meet the Europeans needs of the current time for fresh and healthy food, especially when preserved with PEF. Furthermore, it is important to work towards a sustainable supply chain system from the cultivation until the unloading at the destination in Europe. Sustainability is important for the integration in the European market, not only for environmental protection, but also in terms of social stability and marketing purposes. In addition, access requirements, further food-related regulations, and the seasonality of açaí present a major hurdle.
Building on this thesis, further papers shall be written, not only in the field of the preservation of the açaí pulp with PEF, but also in the direction of combined preservation methods for açaí, the sustainable usage of the açaí seeds, product innovations containing the Brazilian fruit or various market research.
Hintergrund: Instrumentalisten leiden häufig unter spielbedingten (neuro-) muskuloskelettalen Erkrankungen. Diese zeigen sich bei Streichern, wie Violinisten, Bratschisten und Cellisten, am häufigsten in Form von Beschwerden im Oberkörper – insbesondere im Schulter-Nacken-Bereich. Die apparative Bewegungsanalyse hat sich bereits als hilfreich bei der Beurteilung von muskuloskelettalen Erkrankungen und schädlichen Bewegungsmustern erwiesen und wird für die Diagnostik bei funktionellen Störungen empfohlen. Es wurde bereits gezeigt, dass die apparative biomechanische Bewegungsanalyse ein valides und klinisch praktikables Werkzeug für die genaue und objektive Untersuchung von Bewegungen bei Streichern ist, jedoch ist ihr Einsatz in der klinischen Konsultation immer noch sehr unüblich. Aus diesem Grund existiert ein Mangel an gut etablierten Bewegungsanalyse-Protokollen zur Untersuchung funktioneller Störungen bei Streichern unter Einsatz biomechanischer Instrumente in einem klinischen Umfeld wie der Physiotherapie.
Ziel ist es daher, die Entwicklung und Anwendung eines solchen Protokolls vorzustellen für die Beurteilung der funktionellen Spielbewegungen des Oberkörpers bei sowohl hohen als auch tiefen Streichern in einem physiotherapeutischen Umfeld.
Methode: Zunächst wurden auf Basis einer klinischen Fragestellung relevante Symptombereiche und Messparameter bestimmt. Anschließend wurden beteiligte Segmente, Gelenke und Muskeln selektiert. Darauf basierend wurde ein umfassendes (mechanisches) Modell des Oberkörpers sowie die dazugehörigen Koordinatensysteme und Rotationssequenzen definiert. Dies lenkte sowohl die Spezifikation eines speziell angefertigten Marker-Sets sowie fortgeschrittener Ansätze wie zur funktionellen Bestimmung von Gelenkzentren und -achsen, als auch die Auswahl und Platzierung von Oberflächenelektroden. Schließlich wurden Aktivitäten zur Kalibrierung und Untersuchung der Bewegungsfunktion sowie relevante Analyseparameter und deren Darstellungsformen festgelegt.
Die Protokolldurchführung beinhaltet zunächst die Auswahl der zu untersuchenden Segmente, Gelenke und Muskeln ausgehend von einer oder mehreren klinischen (Arbeits-)Hypothesen bzw. von den spezifischen Symptombereichen. Darauf basierend werden die benötigten Marker und Oberflächenelektroden konfiguriert und platziert. Anschließend werden die festgelegten Kalibrierungsmessungen und Bewegungsaufgaben durchgeführt. Schließlich werden die relevanten Ergebnisparameter zur Überprüfung der Hypothesen extrahiert.
Der klinische Einsatz der Methode wird exemplarisch anhand einer Violinistin mit spielbedingten Schmerzen erläutert.
Klinische Implikationen: Die potenzielle Anwendung des vorgestellten Vorgehens ist die intra-individuelle Evaluation von gleichzeitig der Gelenk- als auch der Muskelfunktion bei hohen und tiefen Streichern während der physiotherapeutischen Konsultation. Dies soll sowohl zur Diagnose funktioneller Erkrankungen des Bewegungsapparates in Form einer objektiven, umfassenden und dennoch klinisch praktikablen diagnostischen Untersuchung als auch zum prä-post-interventionellen Vergleich beitragen.
background: Musculoskeletal problems (MP) are widespread in performing artists and are due to the special demands of instrument playing, singing or dancing. Additionally, various other factors might contribute to performance-related MP. To provide a specific physiotherapeutic management for performing artists it is important to gain information about the performing art, the individual demands and contributing factors. The subjective examination (SE) is the basis of the clinical reasoning process and the hypothesis forming for further clinical examination and biomechanical analysis. In the present protocol, the SE consists of a questionnaire-based section and an interview-based section and is part of the evaluation process of the neuromusculoskeletal examination of a performing artist specific reference laboratory.
purpose: To develop a standardized SE protocol divided into a questionnaire-based section (Part 1) via web application and an interview-based SE (Part 2) to address MP of performing artists.
methods: The questionnaires for part 1 were selected based on the expertise of the research group and the psychometric properties of each possible questionnaire. A common physiotherapeutic recording of findings which addresses the relevant questions of the SE of MP was used. To adapt the anamnesis to performing-associated MP questions specific to instrument playing, singing and dancing were selected on the basis of a literature search and the expertise of the research group.
summary of content/results: Part 1 consists of three topics. (1) information about the performing art, professional level and sociodemographic data, (2) information about pain and pain processing, and (3) the anatomical location of the main MP including a body region-specific questionnaire. Part 2 is based on the five aspects of clinical practice described by Maitland and the Musculoskeletal Clinical Translation Framework by Mitchell et al. The performing arts specific part is particularly focused on performing art specific considerations, physical and psychosocial contributing factors and art-specific activities.
significance: This standardized SE protocol should help clinicians evaluating the musculoskeletal health of performing artists in a standardized and specific way.
Background: Musculoskeletal problems (MP) are widespread in performing artists and are due to the special demands of instrument playing, singing or dancing. In order to specifically evaluate these problems, a reference laboratory is under development. The evaluation covers 4 steps: a subjective examination (SE) including (1) a questionnaire-based online survey and (2) an interview-based anamnesis. On the basis of the results of the SE, hypotheses are formed for (3) an individual musculoskeletal clinical examination and a (4) biomechanical analysis. Here, the focus is on the clinical examination.
Purpose: to develop a standardized protocol for a clinical examination addressing especially musculoskeletal problems in performing artists.
Methods: A common physiotherapeutic clinical examination should be supplemented with techniques, which are specific to performance-related musculoskeletal problems and/or their risk factors. The development was based on a literature search and the clinical expertise of the physiotherapeutic research group.
Summary of content/Results: The performing arts specific clinical examination includes the common analysis of posture as well as passive/active movement capacities and specific differentiating tests in relation to the signs and symptoms of the individual artist. The examination is supplemented by a functional demonstration focusing on the special demands of playing the respective instrument, while singing or dancing. Common overuse risk factors like hypermobility, special anthropometric data or an examination of the motor control of different body regions are addressed. Optional, the various parts of the examination process could be skipped, if not relevant for the individual artist.
Significance: This clinical examination protocol should help clinicians evaluating the musculoskeletal health of performing artists in a standardized and specific way.
Die deutschen Kommunen stehen aktuell vor schweren Herausforderungen: der durch die Covid-19-Pandemie bedingte wirtschaftliche Abschwung hat zu massiven Einbrüchen in den kommunalen Steuereinnahmen geführt und gleichzeitig hohe außerplanmäßige Ausgaben bewirkt. Weitere zeitaktuelle Herausforderungen für den kommunalen Finanzhaushalt sind die drohende Energiekrise und die hohe Inflation. Daraus resultierend befinden sich die Kommunen in einer angespannten Haushaltslage und sind gezwungen, unpopuläre Sparmaßnahmen zwecks Haushaltsausgleich einzuleiten. Auch der Landkreis Osnabrück unterliegt einem enormen Konsolidierungsdruck. Die Verwaltungsführung und die politischen Gremien haben beschlossen, ein umfassendes Haushaltskonsolidierungskonzept durchführen zu lassen, im Rahmen dessen u. a. Aufgabenkritik ausgeübt werden soll. Hierbei unterliegen insb. freiwillige Aufgaben einer strengen Aufgabenkritik. Zu den freiwilligen Aufgaben gehört auch die Europaarbeit des ED. Das ED ist eine zentrale europäische Anlaufstelle für die Bevölkerung der Region Osnabrück, bei der sich die Bürger über die EU informieren und zu allerlei europabezogenen Anliegen beraten lassen können. Vor dem Hintergrund der geschilderten Situation steht der ED-Leiter nun vor der Herausforderung, die Europaarbeit des ED vor der Politik und Verwaltungsführung zu rechtfertigen. Aus diesem Anlass untersucht die Verfasserin in der vorliegenden Arbeit, welche Bedeutung dem ED des Landkreises Osnabrück aus Bürgersicht zukommt. Hierzu nimmt sie eine Betrachtung des ED aus aufgabenkritischer Perspektive vor. Im Rahmen der Betrachtung zieht sie die ihr zugrundeliegenden Informationen über das ED sowie Ergebnisse einer stichprobenartigen Umfrage heran.
Im Ergebnis stellt sich heraus, dass die ED-Europaarbeit beibehalten und weiterhin durch den Landkreis Osnabrück wahrgenommen werden sollte. Im Hinblick auf den Geschäftsprozess ergibt sich die Notwendigkeit zu einer Reduktion des Aufgabenumfangs und einer Umpriorisierung der Aufgaben. Insofern bestehen Optimierungspotentiale, die im Rahmen einer GPO näher analysiert werden müssten.
The expiry of national subsidies for biogas in Germany means that new business models are needed. Furthermore, hydrogen is expected to make a significant contribution to the energy transition in the future. Therefore, potentials for the production of hydrogen from biogas are identified in this study. A joint upgrading infrastructure is developed that models the collaborative upgrading of biogas to hydrogen for existing biogas plants with subsequent gas grid injection. Furthermore, regions are identified that are particularly suitable as pioneer regions in Germany due to a high potential for green hydrogen production and comparatively low costs for hydrogen production. The modeling shows that collaborative upgrading achieves significant cost savings compared to single-farm upgrading. Furthermore, the potential for hydrogen production from biogas and the costs of upgrading differ significantly within the administrative districts in Germany.
The increasing diversity of cultural backgrounds offers potential for a more elaborated information processing, yet has been shown to be challenging for individuals, due to intergroup hostility, prejudices, and difficulties of intercultural communication. Current research thus focusses on the interaction of employees with different cultural heritages, as well as on their intergroup attitudes and competences. Thereby, leaders have been shown to shape the way diversity is considered in their teams in a top-down process. However, their perception of diversity as well as related challenges and chances are poorly investigated. The current paper thus aims to contribute to the understanding of leader’s perspective on and role in diversity-management by building on a comparative qualitative study with sixteen employees and twenty-two leaders. Research questions are how employees and leaders perceive cultural diversity from their specific point of view, which experiences are likely to contribute to their opinion on and perception of diversity and in how far do employees and leaders differ in these aspects. The results show that employees are aware of the topic of diversity in general but have poor competences in dealing with diversity in their daily working life. This seems to be associated with lack of experience with intercultural interaction and a lack of support from the respective organizations/leaders. Leaders are rarely aware of this lack of support. The results indicate that leaders’ experiences with cultural and age diversity, their identification with the company and previous diversity measures in the context of the companies’ policy towards diversity seem to be relevant for the formation of leaders’ attitudes. As a consequence, most participants focus on the question whether they do or do not want diversity within their teams and companies, while they actually fail to perceive the diversity that is already there.
The Corona pandemic confronted societies with several unexpected constraints that had the effect of making certain goods much scarcer than before. Withdrawal from Russian oil and gas supplies has a similar effect. Carbon abatement can also be seen as a deliberate choice to make certain goods scarc-er than they actually are. These parallels suggests that it may be worthwhile to take a close look at societies’ responses to all three challenges. This paper makes an attempt to synthetize empirical and theoretical insights regarding these scarcity shocks from a well-being perspective, i.e. replacing the prevalent welfare economic focus on production and consumption with a focus on sustainable well-being.
Taking the case of Germany, it will be argued that the observed responses to all three challenges reflect a focus on maintaining incomes and production and that therefore these responses risk being detrimental to sustainable wellbeing and even to economic stability. This is particularly relevant if carbon abatement requires not only transient material sacrifices but lasting and significant reduc-tions of consumption.
It will be argued that the impact of these new scarcities will be much less problematic in a society that acknowledges the priority of sustainable wellbeing over production and consumption measures. Such a society would still need to incur material sacrifices, but these need not translate into a loss of wellbeing if economic conditions and social norms adapt. This will also be more sustainable not only in terms of ecological impact, but also in terms of debt, inflation and inequality.
The contribution follows the hypothesis that the concept of transformative resilience can be a driver in transdisciplinary processes bringing together landscape planning and landscape design. Combining processes of generating, structuring and spatializing knowledge on landscape functions and designing visions for sustainable landscapes on different scales benefits from the creative use of mappings.
Taking the transdisciplinary research study “Green fingers for a climate resilient city”, funded by the German Ministry of education and research (BMBF), as an example, this paper follows the hypothesis that processes of landscape planning and designing multifunctional green spaces and processes of co-creation need to be combined to stimulate climate resilient city transformation. The findings are that efforts to combine these processes benefit from making complex climate-resilient city planning accessible for people of different professional backgrounds. The paper showcases how storytelling (Schmidt 2019), mapping (Langner 2009) and guided walks (Schultz 2019) are means to mutually engage with, perceive and understand multifunctional green spaces, inspire ownership, and build capacity for the city’s climate-resilient transformation.
When the ECLAS Conference took place in 1972 western societies were undergoing profound change: They transformed from industrial to postindustrial societies – the so-called service societies. 50 years later, the knowledge society is emerging: Knowledge is considered the key resource of this era. Digitalization and widespread dissemination of ICT allow information to be obtained anywhere anytime. This has severe implications for individual lifestyles and everyday practices. Different aspects of living, learning and working are no longer bound to physical limitations but can be enhanced by or even transferred to the virtual space. So being on the move today means travelling in hybrid spaces. We call this the space and practice “en route”.
At the University of Applied Sciences Osnabrück we explore the following questions:
What does “en route” mean and look like in landscapes of higher education?
How is it perceived individually?
(How) can landscape architecture shape it?
Our transdisciplinary research project EN ROUTE aims to meet current challenges at universities (e.g. digitalisation, sustainable development) with a comprehensive understanding of space and practices “en route”. In a transdisciplinary process, researchers from various disciplines – landscape architecture, geography, urban planning, business administrations and marketing, energy technology and computer science – develop concepts and strategies for sustainable and digital mobility in the higher education sector. New “EN ROUTE” types provide insights into the individual production and utilization of spaces “en route”.
The campuses of the University of Applied Science Osnabrück as well as the virtual and physical space network of its members serve as research example. Initial findings will be presented at the conference. While the ECLAS conference in 1972 focused on physical scales, landscape architecture has to reflect them critically and ask: What could be an innovative understanding of spaces “en route”?