610 Medizin, Gesundheit
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Institute
Background:
Etomidate is typically used as an induction agent in cardiac surgery because it has little impact on hemodynamics. It is a known suppressor of adrenocortical function and may increase the risk for post-operative infections, sepsis, and mortality. The aim of this study was to evaluate whether etomidate increases the risk of postoperative sepsis (primary outcome) and infections (secondary outcome) compared to propofol.
Methods:
This was a retrospective before–after trial (IRB EA1/143/20) performed at a tertiary medical center in Berlin, Germany, between 10/2012 and 01/2015. Patients undergoing cardiac surgery were investigated within two observation intervals, during which etomidate and propofol were the sole induction agents.
Results:
One-thousand, four-hundred, and sixty-two patients, and 622 matched pairs, after caliper propensity-score matching, were included in the final analysis. Sepsis rates did not differ in the matched cohort (etomidate: 11.5% vs. propofol: 8.2%, p = 0.052). Patients in the etomidate interval were more likely to develop hospital-acquired pneumonia (etomidate: 18.6% vs. propofol: 14.0%, p = 0.031).
Conclusion:
Our study showed that a single-dose of etomidate is not statistically associated with higher postoperative sepsis rates after cardiac surgery, but is associated with a higher incidence of hospital-acquired pneumonia. However, there is a notable trend towards a higher sepsis rate.
Background:
Cardiac surgery patients represent a high-risk cohort in intensive care units (ICUs). Central venous pressure (CVP) measurement seems to remain an integral part in hemodynamic monitoring, especially in cardio-surgical ICUs. However, its value as a prognostic marker for organ failure is still unclear. Therefore, we analyzed postoperative CVP values after adult cardiac surgery in a large cohort with regard to its prognostic value for morbidity and mortality.
Methods:
All adult patients admitted to our ICUs between 2006 and 2019 after cardiac surgery were eligible for inclusion in the study (n = 11,198). We calculated the median initial CVP (miCVP) after admission to the ICU, which returned valid values for 9802 patients. An ROC curve analysis for optimal cut-off miCVP to predict ICU mortality was conducted with consecutive patient allocation into a (a) low miCVP (LCVP) group (≤11 mmHg) and (b) high miCVP (HCVP) group (>11 mmHg). We analyzed the impact of high miCVP on morbidity and mortality by propensity score matching (PSM) and logistic regression.
Results:
ICU mortality was increased in HCVP patients. In addition, patients in the HCVP group required longer mechanical ventilation, had a higher incidence of acute kidney injury, were more frequently treated with renal replacement therapy, and showed a higher risk for postoperative liver dysfunction, parametrized by a postoperative rise of ≥ 10 in MELD Score. Multiple regression analysis confirmed HCVP has an effect on postoperative ICU-mortality and intrahospital mortality, which seems to be independent.
Conclusions:
A high initial CVP in the early postoperative ICU course after cardiac surgery is associated with worse patient outcome. Whether or not CVP, as a readily and constantly available hemodynamic parameter, should promote clinical efforts regarding diagnostics and/or treatment, warrants further investigations.
Preoperative medication use and development of postoperative delirium and cognitive dysfunction
(2021)
Postoperative delirium (POD) and postoperative (neuro-)cognitive disorder (POCD) are frequent and serious complications after operations. We aim to investigate the association between pre-operative polypharmacy and potentially inappropriate medications and the development of POD/POCD in elderly patients. This investigation is part of the European BioCog project (www.biocog.eu), a prospective multicenter observational study with elderly surgical patients. Patients with a Mini-Mental State Examination score less than or equal to 23 points were excluded. POD was assessed up to 7 days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method (for the intensive care unit [ICU]), and a patient chart review. POCD was assessed 3 months after surgery with a neuropsychological test battery. Pre-operative long-term medication was evaluated in terms of polypharmacy (≥5 agents) and potentially inappropriate medication (defined by the PRISCUS and European list of potentially inappropriate medications [EU(7)-PIM] lists), and associations with POD and POCD were analyzed using logistic regression analysis. Eight hundred thirty-seven participants were included for analysis of POD and 562 participants for POCD. Of these, 165 patients (19.7%) fulfilled the criteria of POD and 60 (10.7%) for POCD. After adjusting for confounders, pre-operative polypharmacy and intake of potentially inappropriate medications could not be shown to be associated with the development of POD nor POCD. We found no associations between pre-operative polypharmacy and potentially inappropriate medications and development of POD and POCD. Future studies should focus on the evaluation of drug interactions to determine whether patients benefit from a pre-operative adjustment.
The benzodiazepine, midazolam, is one of the most frequently used sedatives in intensive care medicine, but it has an unfavorable pharmacokinetic profile when continuously applied. As a consequence, patients are frequently prolonged and more deeply sedated than intended. Due to its distinct pharmacological features, including a cytochrome P450-independent metabolization, intravenous lormetazepam might be clinically advantageous compared to midazolam. In this retrospective cohort study, we compared patients who received either intravenous lormetazepam or midazolam with respect to their survival and sedation characteristics. The cohort included 3314 mechanically ventilated, critically ill patients that received one of the two drugs in a tertiary medical center in Germany between 2006 and 2018. A Cox proportional hazards model with mortality as outcome and APACHE II, age, gender, and admission mode as covariates revealed a hazard ratio of 1.75 [95% CI 1.46–2.09; p < 0.001] for in-hospital mortality associated with the use of midazolam. After additionally adjusting for sedation intensity, the HR became 1.04 [95% CI 0.83–1.31; p = 0.97]. Thus, we concluded that excessive sedation occurs more frequently in critically ill patients treated with midazolam than in patients treated with lormetazepam. These findings require further investigation in prospective trials to assess if lormetazepam, due to its ability to maintain light sedation, might be favorable over other benzodiazepines for sedation in the ICU.
Objective:
The cervical mucus plugs are enriched with proteins of known immunological functions. We aimed to characterize the anti-HIV-1 activity of the cervical mucus plugs against a panel of different HIV-1 strains in the contexts of cell-free and cell-associated virus.
Design:
A cohort of consenting HIV-1-negative and HIV-1-positive pregnant women in labour was recruited from Mthatha General Hospital in the Eastern Cape province of South Africa, from whom the cervical mucus plugs were collected in 6 M guanidinium chloride with protease inhibitors and transported to our laboratories at −80 °C.
Methods:
Samples were centrifuged to remove insoluble material and dialysed before freeze--drying and subjecting them to the cell viability assays. The antiviral activities of the samples were studied using luminometric reporter assays and flow cytometry. Time-of-addition and BlaM-Vpr virus-cell fusion assays were used to pin-point the antiviral mechanisms of the cervical mucus plugs, before proteomic profiling using liquid chromatography-tandem mass spectrometry.
Results:
The proteinaceous fraction of the cervical mucus plugs exhibited anti-HIV-1 activity with inter-individual variations and some degree of specificity among different HIV-1 strains. Cell-associated HIV-1 was less susceptible to inhibition by the potent samples whenever compared with the cell-free HIV-1. The samples with high antiviral potency exhibited a distinct proteomic profile when compared with the less potent samples.
Conclusion:
The crude cervical mucus plugs exhibit anti-HIV-1 activity, which is defined by a specific proteomic profile.
Background
In DNA methylation analyses like epigenome-wide association studies, effects in differentially methylated CpG sites are assessed. Two kinds of outcomes can be used for statistical analysis: Beta-values and M-values. M-values follow a normal distribution and help to detect differentially methylated CpG sites. As biological effect measures, differences of M-values are more or less meaningless. Beta-values are of more interest since they can be interpreted directly as differences in percentage of DNA methylation at a given CpG site, but they have poor statistical properties. Different frameworks are proposed for reporting estimands in DNA methylation analysis, relying on Beta-values, M-values, or both.
Results
We present and discuss four possible approaches of achieving estimands in DNA methylation analysis. In addition, we present the usage of M-values or Beta-values in the context of bioinformatical pipelines, which often demand a predefined outcome. We show the dependencies between the differences in M-values to differences in Beta-values in two data simulations: a analysis with and without confounder effect. Without present confounder effects, M-values can be used for the statistical analysis and Beta-values statistics for the reporting. If confounder effects exist, we demonstrate the deviations and correct the effects by the intercept method. Finally, we demonstrate the theoretical problem on two large human genome-wide DNA methylation datasets to verify the results.
Conclusions
The usage of M-values in the analysis of DNA methylation data will produce effect estimates, which cannot be biologically interpreted. The parallel usage of Beta-value statistics ignores possible confounder effects and can therefore not be recommended. Hence, if the differences in Beta-values are the focus of the study, the intercept method is recommendable. Hyper- or hypomethylated CpG sites must then be carefully evaluated. If an exploratory analysis of possible CpG sites is the aim of the study, M-values can be used for inference.
BACKGROUND:
Intraoperative electroencephalography (EEG) signatures related to the development of postoperative delirium (POD) in older patients are frequently studied. However, a broad analysis of the EEG dynamics including preoperative, postinduction, intraoperative and postoperative scenarios and its correlation to POD development is still lacking. We explored the relationship between perioperative EEG spectra-derived parameters and POD development, aiming to ascertain the diagnostic utility of these parameters to detect patients developing POD.
METHODS:
Patients aged ≥65 years undergoing elective surgeries that were expected to last more than 60 minutes were included in this prospective, observational single center study (Biomarker Development for Postoperative Cognitive Impairment [BioCog] study). Frontal EEGs were recorded, starting before induction of anesthesia and lasting until recovery of consciousness. EEG data were analyzed based on raw EEG files and downloaded excel data files. We performed multitaper spectral analyses of relevant EEG epochs and further used multitaper spectral estimate to calculate a corresponding spectral parameter. POD assessments were performed twice daily up to the seventh postoperative day. Our primary aim was to analyze the relation between the perioperative spectral edge frequency (SEF) and the development of POD.
RESULTS:
Of the 237 included patients, 41 (17%) patients developed POD. The preoperative EEG in POD patients was associated with lower values in both SEF (POD 13.1 ± 4.6 Hz versus no postoperative delirium [NoPOD] 17.4 ± 6.9 Hz; P = .002) and corresponding γ-band power (POD −24.33 ± 2.8 dB versus NoPOD −17.9 ± 4.81 dB), as well as reduced postinduction absolute α-band power (POD −7.37 ± 4.52 dB versus NoPOD −5 ± 5.03 dB). The ratio of SEF from the preoperative to postinduction state (SEF ratio) was ~1 in POD patients, whereas NoPOD patients showed a SEF ratio >1, thus indicating a slowing of EEG with loss of unconscious. Preoperative SEF, preoperative γ-band power, and SEF ratio were independently associated with POD (P = .025; odds ratio [OR] = 0.892, 95% confidence interval [CI], 0.808–0.986; P = .029; OR = 0.568, 95% CI, 0.342–0.944; and P = .009; OR = 0.108, 95% CI, 0.021–0.568, respectively).
CONCLUSIONS:
Lower preoperative SEF, absence of slowing in EEG while transitioning from preoperative state to unconscious state, and lower EEG power in relevant frequency bands in both these states are related to POD development. These findings may suggest an underlying pathophysiology and might be used as EEG-based marker for early identification of patients at risk to develop POD.
Background
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are frequent and serious complications after surgery. We aim to investigate the association between genetic variants in cholinergic candidate genes according to the Kyoto encyclopedia of genes and genomes - pathway: cholinergic neurotransmission with the development of POD or POCD in elderly patients.
Methods
This analysis is part of the European BioCog project (www.biocog.eu), a prospective multicenter observational study with elderly surgical patients. Patients with a Mini-Mental-State-Examination score ≤ 23 points were excluded. POD was assessed up to seven days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method and a patient chart review. POCD was assessed three months after surgery with a neuropsychological test battery. Genotyping was performed on the Illumina Infinium Global Screening Array. Associations with POD and POCD were analyzed using logistic regression analysis, adjusted for age, comorbidities and duration of anesthesia (for POCD analysis additionally for education). Odds ratios (OR) refer to minor allele counts (0, 1, 2).
Results
745 patients could be included in the POD analysis, and 452 in the POCD analysis. The rate of POD within this group was 20.8% (155 patients), and the rate of POCD was 10.2% (46 patients). In a candidate gene approach three genetic variants of the cholinergic genes CHRM2 and CHRM4 were associated with POD (OR [95% confidence interval], rs8191992: 0.61[0.46; 0.80]; rs8191992: 1.60[1.22; 2.09]; rs2067482: 1.64[1.10; 2.44]). No associations were found for POCD.
Conclusions
We found an association between genetic variants of CHRM2 and CHRM4 and POD. Further studies are needed to investigate whether disturbances in acetylcholine release and synaptic plasticity are involved in the development of POD.
Background
In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammation. Epigenetic modifications of the chromatin confer plasticity to the genetic information and give insight into how tissues use the genetic information to adapt to environmental factors. The oral mucosa is particularly exposed to environmental stressors such as a variable microbiota. Likewise, persistent oral inflammation is the most important intrinsic risk factor for the oral inflammatory disease periodontitis and has strong potential to alter DNA-methylation patterns. The aim of the current study was to identify epigenetic changes of the oral masticatory mucosa in response to long-term inflammation that resulted in periodontitis.
Methods and results
Genome-wide CpG methylation of both inflamed and clinically uninflamed solid gingival tissue biopsies of 60 periodontitis cases was analyzed using the Infinium MethylationEPIC BeadChip. We validated and performed cell-type deconvolution for infiltrated immune cells using the EpiDish algorithm. Effect sizes of DMPs in gingival epithelial and fibroblast cells were estimated and adjusted for confounding factors using our recently developed “intercept-method”. In the current EWAS, we identified various genes that showed significantly different methylation between periodontitis-inflamed and uninflamed oral mucosa in periodontitis patients. The strongest differences were observed for genes with roles in wound healing (ROBO2, PTP4A3), cell adhesion (LPXN) and innate immune response (CCL26, DNAJC1, BPI). Enrichment analyses implied a role of epigenetic changes for vesicle trafficking gene sets.
Conclusions
Our results imply specific adaptations of the oral mucosa to a persistent inflammatory environment that involve wound repair, barrier integrity, and innate immune defense.
A comparison study on modeling of clustered and overdispersed count data for multiple comparisons
(2021)
Data collected in various scientific fields are count data. One way to analyze such data is to compare the individual levels of the factor treatment using multiple comparisons. However, the measured individuals are often clustered – e.g. according to litter or rearing. This must be considered when estimating the parameters by a repeated measurement model. In addition, ignoring the overdispersion to which count data is prone leads to an increase of the type one error rate. We carry out simulation studies using several different data settings and compare different multiple contrast tests with parameter estimates from generalized estimation equations and generalized linear mixed models in order to observe coverage and rejection probabilities. We generate overdispersed, clustered count data in small samples as can be observed in many biological settings. We have found that the generalized estimation equations outperform generalized linear mixed models if the variance-sandwich estimator is correctly specified. Furthermore, generalized linear mixed models show problems with the convergence rate under certain data settings, but there are model implementations with lower implications exists. Finally, we use an example of genetic data to demonstrate the application of the multiple contrast test and the problems of ignoring strong overdispersion.
Objectives: To measure and assess the economic impact of adherence to a single quality indicator (QI) regarding weaning from invasive ventilation.
Design: Retrospective observational single-centre study, based on electronic medical and administrative records.
Setting: Intensive care unit (ICU) of a German university hospital, reference centre for acute respiratory distress syndrome.
Participants: Records of 3063 consecutive mechanically ventilated patients admitted to the ICU between 2012 and 2017 were extracted, of whom 583 were eligible adults for further analysis. Patients’ weaning protocols were evaluated for daily adherence to quality standards until ICU discharge. Patients with <65% compliance were assigned to the low adherence group (LAG), patients with ≥65% to the high adherence group (HAG).
Primary and secondary outcome measures: Economic healthcare costs, clinical outcomes and patients’ characteristics.
Results: The LAG consisted of 378 patients with a median negative economic results of −€3969, HAG of 205 (−€1030), respectively (p<0.001). Median duration of ventilation was 476 (248; 769) hours in the LAG and 389 (247; 608) hours in the HAG (p<0.001). Length of stay (LOS) in the LAG on ICU was 21 (12; 35) days and 16 (11; 25) days in the HAG (p<0.001). LOS in the hospital was 36 (22; 61) days in the LAG, and within the HAG, respectively, 26 (18; 48) days (p=0.001).
Conclusions: High adherence to this single QI is associated with better clinical outcome and improved economic returns. Therefore, the results support the adherence to QI. However, the examined QI does not influence economic outcome as the decisive factor.
During gestation, the most drastic change in oxygen supply occurs with the onset of ventilation after birth. As the too early exposure of premature infants to high arterial oxygen pressure leads to characteristic diseases, we studied the adaptation of the oxygen sensing system and its targets, the hypoxia-inducible factor- (HIF-) regulated genes (HRGs) in the developing lung. We draw a detailed picture of the oxygen sensing system by integrating information from qPCR, immunoblotting, in situ hybridization, and single-cell RNA sequencing data in ex vivo and in vivo models. HIF1α protein was completely destabilized with the onset of pulmonary ventilation, but did not coincide with expression changes in bona fide HRGs. We observed a modified composition of the HIF-PHD system from intrauterine to neonatal phases: Phd3 was significantly decreased, while Hif2a showed a strong increase and the Hif3a isoform Ipas exclusively peaked at P0. Colocalization studies point to the Hif1a-Phd1 axis as the main regulator of the HIF-PHD system in mouse lung development, complemented by the Hif3a-Phd3 axis during gestation. Hif3a isoform expression showed a stepwise adaptation during the periods of saccular and alveolar differentiation. With a strong hypoxic stimulus, lung ex vivo organ cultures displayed a functioning HIF system at every developmental stage. Approaches with systemic hypoxia or roxadustat treatment revealed only a limited in vivo response of HRGs. Understanding the interplay of the oxygen sensing system components during the transition from saccular to alveolar phases of lung development might help to counteract prematurity-associated diseases like bronchopulmonary dysplasia.
Background
A peripheral venous catheter (PVC) is the most widely used device for obtaining vascular access, allowing the administration of fluids and medication. Up to 25% of adult patients, and 50% of pediatric patients experience a first-attempt cannulation failure. In addition to patient and clinician characteristics, device features might affect the handling and success rates. The objective of the study was to compare the first-attempt cannulation success rate between PVCs with wings and a port access (Vasofix® Safety, B. Braun, abbreviated hereon in as VS) with those without (Introcan® Safety, B. Braun, abbreviated hereon in as IS) in an anesthesiological cohort.
Methods
An open label, multi-center, randomized trial was performed. First-attempt cannulation success rates were examined, along with relevant patient, clinician, and device characteristics with univariate and multivariate analyses. Information on handling and adherence to use instructions was gathered, and available catheters were assessed for damage.
Results
Two thousand three hundred four patients were included in the intention to treat analysis. First-attempt success rate was significantly higher with winged and ported catheters (VS) than with the non-winged, non-ported design (IS) (87.5% with VS vs. 78.2% with IS; PChi < .001). Operators rated the handling of VS as superior (rating of “good” or “very good: 86.1% VS vs. 20.8% IS, PChi < .001). Reinsertion of the needle into the catheter after partial withdrawal—prior or during the catheterization attempt—was associated with an increased risk of cannulation failure (7.909, CI 5.989–10.443, P < .001 and 23.023, CI 10.372–51.105, P < .001, respectively) and a twofold risk of catheter damage (OR 1.999, CI 1.347–2.967, P = .001).
Conclusions
First-attempt cannulation success of peripheral, ported, winged catheters was higher compared to non-ported, non-winged devices. The handling of the winged and ported design was better rated by the clinicians. Needle reinsertions are related to an increase in rates of catheter damage and cannulation failure.
Background: New ischaemic brain lesions on magnetic resonance imaging (MRI) are reported in up to 86% of patients after transcatheter edge-to-edge repair of the mitral valve (TEER-MV). Knowledge of the exact procedural step(s) that carry the highest risk for cerebral embolisation may help to further improve the procedure.
Aims: The aim of this study was to identify the procedural step(s) that are associated with an increased risk of cerebral embolisation during TEER-MV with the MitraClip system. Furthermore, the risk of overt stroke and silent brain ischaemia after TEER-MV was assessed.
Methods: In this prospective, pre-specified observational study, all patients underwent continuous transcranial Doppler examination during TEER-MV to detect microembolic signals (MES). MES were assigned to specific procedural steps: (1) transseptal puncture and placement of the guide, (2) advancing and adjustment of the clip in the left atrium, (3) device interaction with the MV, and (4) removal of the clip delivery system and the guide. Neurological examination using the National Institutes of Health Stroke Scale (NIHSS) and cerebral MRI were performed before and after TEER-MV.
Results: Fifty-four patients were included. The number of MES differed significantly between the procedural steps with the highest numbers observed during device interaction with the MV. Mild neurological deterioration (NIHSS ≤3) occurred in 9/54 patients. New ischaemic lesions were detected in 21/24 patients who underwent MRI. Larger infarct volume was significantly associated with neurological deterioration.
Conclusions: Cerebral embolisation is immanent to TEER-MV and predominantly occurs during device interaction with the MV. Improvements to the procedure may focus on this procedural step.
Background
To detect changes in biological processes, samples are often studied at several time points. We examined expression data measured at different developmental stages, or more broadly, historical data. Hence, the main assumption of our proposed methodology was the independence between the examined samples over time. In addition, however, the examinations were clustered at each time point by measuring littermates from relatively few mother mice at each developmental stage. As each examination was lethal, we had an independent data structure over the entire history, but a dependent data structure at a particular time point. Over the course of these historical data, we wanted to identify abrupt changes in the parameter of interest - change points.
Results
In this study, we demonstrated the application of generalized hypothesis testing using a linear mixed effects model as a possible method to detect change points. The coefficients from the linear mixed model were used in multiple contrast tests and the effect estimates were visualized with their respective simultaneous confidence intervals. The latter were used to determine the change point(s). In small simulation studies, we modelled different courses with abrupt changes and compared the influence of different contrast matrices. We found two contrasts, both capable of answering different research questions in change point detection: The Sequen contrast to detect individual change points and the McDermott contrast to find change points due to overall progression. We provide the R code for direct use with provided examples. The applicability of those tests for real experimental data was shown with in-vivo data from a preclinical study.
Conclusion
Simultaneous confidence intervals estimated by multiple contrast tests using the model fit from a linear mixed model were capable to determine change points in clustered expression data. The confidence intervals directly delivered interpretable effect estimates representing the strength of the potential change point. Hence, scientists can define biologically relevant threshold of effect strength depending on their research question. We found two rarely used contrasts best fitted for detection of a possible change point: the Sequen and McDermott contrasts.
BACKGROUND: Postoperative delirium (POD) is an acute and common complication after surgery that can increase morbidity and mortality. Few previous studies with inconsistent findings have examined the association of preoperative pain and POD. Our purpose is to investigate the association of preoperative chronic pain and POD.
METHODS: This prospective observational cohort study included 200 patients ≥ 18 years scheduled for elective surgery under general anaesthesia in a tertiary care hospital. POD was defined as meeting diagnostic criteria during the study visits (according to delirium screening tests and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition), or by diagnosis of the responsible physicians. Chronic pain was defined as pain lasting six months or longer. Features of chronic pain were assessed with the German Pain Questionnaire, including the Depression Anxiety and Stress Scale-21 (DASS-21). Associations with POD were assessed using logistic regression analysis adjusting for confounding factors.
RESULTS: Thirty-nine (22%) out of 176 patients developed POD. Chronic pain was not associated with POD after adjustment for ASA physical status, duration of anesthesia and DASS-21 Anxiety score (Odds ratio [OR], 95%-Confidence Interval [CI], 2.216 [0.968;5.070], P=0.060). A subgroup analysis of chronic pain patients revealed that current pain intensity was higher in patients with POD.
CONCLUSIONS: Preoperative chronic pain was no independent predictor for POD. Current pain intensity was higher in chronic pain patients with POD. This indicates that certain features of pain might be influential. Further research is needed to examine different forms of preoperative pain and their possible influence on POD.
Hintergrund
Die Anämie hat eine hohe Prävalenz bei Patienten vor Hüftgelenkrevisionsoperation und ist mit einer erhöhten Komplikationsrate assoziiert. Die vorliegende Arbeit untersucht erstmals den Zusammenhang von Kosten, realen DRG-Erlösen und Falldeckung der präoperativen Anämie bei elektiven Hüftgelenkrevisionsoperationen.
Methoden
Für alle Patienten, die sich von 2010 bis 2017 an 2 Campi der Charité – Universitätsmedizin Berlin einer Hüftgelenkrevisionsoperation unterzogen, wurden Daten zu Patienten sowie Transfusionen, Kosten und Erlösen gesammelt. Subgruppen- und lineare Regressionsanalysen untersuchten die Falldeckung anämischer und nichtanämischer Patienten.
Ergebnisse
Von 1187 eingeschlossenen Patienten waren 354 (29,8 %) präoperativ anämisch. Insgesamt wurden 565 (47,6 %) Patienten, mit einem deutlichen Überwiegen anämischer Patienten (72,6 % vs. 37,0 %, p < 0,001), transfundiert. Kosten (12.318 € [9027;20.044 €] vs. 8948 € [7501;11.339 €], p < 0,001) und Erlöse (11.788 € [8992;16.298 €] vs. 9611 € [8332;10.719 €], p < 0,001) waren für anämische Patienten höher, die Fallkostendeckung defizitär (−1170 € [−4467;1238 €] vs. 591 € [−1441;2103 €] €, p < 0,001). Bei anämischen Patienten nahm die Falldeckung mit zunehmender Transfusionsrate ab (p ≤ 0,001). Komorbiditäten hatten keinen signifikanten ökonomischen Einfluss.
Schlussfolgerung
Die präoperative Anämie und perioperative Transfusionen bei Hüftgelenkrevisionsoperationen sind mit erhöhten Behandlungskosten und einer finanziellen Unterdeckung für Kostenträger im Gesundheitswesen verbunden. Konzepte zur Behandlung der präoperativen Anämie (z. B. Patient Blood Management) könnten mittelfristig Behandlungskosten senken.
Intensive care units (ICU) are often overflooded with alarms from monitoring devices which constitutes a hazard to both staff and patients. To date, the suggested solutions to excessive monitoring alarms have remained on a research level. We aimed to identify patient characteristics that affect the ICU alarm rate with the goal of proposing a straightforward solution that can easily be implemented in ICUs. Alarm logs from eight adult ICUs of a tertiary care university-hospital in Berlin, Germany were retrospectively collected between September 2019 and March 2021. Adult patients admitted to the ICU with at least 24 h of continuous alarm logs were included in the study. The sum of alarms per patient per day was calculated. The median was 119. A total of 26,890 observations from 3205 patients were included. 23 variables were extracted from patients' electronic health records (EHR) and a multivariable logistic regression was performed to evaluate the association of patient characteristics and alarm rates. Invasive blood pressure monitoring (adjusted odds ratio (aOR) 4.68, 95%CI 4.15–5.29, p < 0.001), invasive mechanical ventilation (aOR 1.24, 95%CI 1.16–1.32, p < 0.001), heart failure (aOR 1.26, 95%CI 1.19–1.35, p < 0.001), chronic renal failure (aOR 1.18, 95%CI 1.10–1.27, p < 0.001), hypertension (aOR 1.19, 95%CI 1.13–1.26, p < 0.001), high RASS (aOR 1.22, 95%CI 1.18–1.25, p < 0.001) and scheduled surgical admission (aOR 1.22, 95%CI 1.13–1.32, p < 0.001) were significantly associated with a high alarm rate. Our study suggests that patient-specific alarm management should be integrated in the clinical routine of ICUs. To reduce the overall alarm load, particular attention regarding alarm management should be paid to patients with invasive blood pressure monitoring, invasive mechanical ventilation, heart failure, chronic renal failure, hypertension, high RASS or scheduled surgical admission since they are more likely to have a high contribution to noise pollution, alarm fatigue and hence compromised patient safety in ICUs.
The impact of Pulsed Electric Field (PEF) processing pre-treatment on the texture and kinetics of in vitro starch digestibility of French fries made from two potato cultivars (Solanum tuberosum L.) containing dry matter content ranging from 19 to 22% was investigated. Whole and steam-peeled potato tubers were treated with a pilot scale PEF unit (electric field strength of 1.1 and 1.9 kV/cm with energy input <10 kJ/kg or ∼50 kJ/kg). This trial was carried out in a commercial French-fry plant using an industrial scale cutter, blancher, fryer and blast-freezer to prepare the frozen par-fried French fry samples. After subsequent final batch frying of the frozen fries, at 180 °C for 3 min to mimic the typical preparation practice at restaurant, retail and household, the outer crust of the fries produced from PEF-treated potatoes was significantly harder (9.4–16.3 N) than crust produced from untreated potatoes (6.9–8.5 N). High intensity (1.9 kV/cm with energy input ∼50 kJ/kg) PEF processing was found to cause defects (i.e. hollowness in the internal core) in the fries. A fractional conversion model was a good fit for the starch digestion kinetics of all French fry samples during the small intestinal phase (based on standardised INFOGEST static in vitro digestion assay). A lower % of total starch hydrolysis was predicted for French fries produced from high dry matter (>21%) tubers pretreated with PEF at electric field strength of 1.9 kV/cm. The findings generated in this study demonstrate PEF pretreatment may influence the texture of French fries and the extent of starch digestion that occurs.
Shockwaves are mechanical pressure pulses generated in liquids and gases. Based on the principles of acoustics, shockwavescan propagate through fluids such as water. At interfaces of materials with different acoustic impedances, mechanical energy is dissipated, and disintegration of biological tissue can be achieved. Physical properties as well as technical requirements for shockwave generation by electrohydraulic, electromagnetic or piezoelectric energy conversion have been reported in the literature. The use of electrohydraulic shockwaves for food treatment is an emerging food processing technology, where a lack of scientific and technical knowledge has limited further advancements in process and equipment design. In scientific literature, single aspects required for process description are available, e.g., in metallurgy, mining, air purification or particle accelerators, but their combination toward a combined model is required to characterize underlying mechanisms of action. In food, most of the studies have focused on shockwave technology for treatment of meat cuts with the purpose of reducing aging time, softening of tissue and improving its tenderness. Other applications of the shockwave technology could expand to biological inactivation, targeted texture modifications and improving extractive and refining processes in agriculture industries. Total processing costs are estimated in a range of a few Euros per ton of product. Despite being a promising alternative to existing processes used for these purposes, the application of shockwave in the food industry is limited to date to research on pilot-scale prototypes.
This chapter presents the mechanism of the enhancement of freezing by means of ultrasound (US). It has been demonstrated that the effects of US are a rather complex issue. In theory, ultrasound creates cavitation bubbles throughout the volume of the product, which promotes nucleation of the ice and crushes the crystals already present in food. They can also enhance convective heat transfer to the cooling media, thereby accelerating freezing. Moreover, it has been shown that ultrasound reduces the degree of supercooling before nucleation in frozen food. Additionally, numerous experimental studies indicate that ultrasound assisted freezing is a good method to achieve homogenous crystallizations, reduce the deteriorating effect of freezing on food, and thus improve quality after thawing.
Among all nonthermal food processing technologies, high intensity pulsed electric fields (PEF) is one of the most appealing due to its short treatment times and reduced heating effects. Its capability to enhance extraction processes and to inactivate microorganisms at temperatures that do not cause any deleterious effect on flavor, color or nutrient value of foods opens interesting possibilities for the food processing industry.
This new and revised edition of Pulsed Electric Fields Technology for the Food Industry presents the information accumulated on PEF over the last decade by experienced microbiologists, biochemists, food technologists and electrical and food engineers. With insight into current applications of PEF across the food industry, this text offers a comprehensive and up to date resource on PEF application in the food industry from the scientific fundamentals to its use in various food types to environmental and regulatory aspects. For researchers and industry professionals seeking a single source containing all of the relevant and up to date information on PEF in foods, look no further than this essential text.
The influence of moderate electric fields (MEF) on thermally induced gelation and network structures of patatin enriched potato protein (PPI) was investigated. PPI solutions with 9 wt% protein (pH 7) and 25 mM NaCl were heated from 25 to 65 °C via OH (3–24 V/cm) or conventional heating (COV) at various come-up (240 s and 1200 s) and holding times (30 s and 600 s). Self-standing gels were produced but less proteins denatured when heated via OH. Further, SDS-PAGE and GPC measurements revealed more native patatin remaining after OH treatment. Scanning electron microscopy showed OH gels to have more gap-like structures and frayed areas than COV treated gels which resulted in lower water holding capacity. On molecular scale, less hydrophobic interactions were measured within the protein network and FTIR trials showed the MEF to affect beta-sheet structures. OH gels further showed lower rigidity and higher flexibility, thus, gelling functionality was affected via OH.
Novel foods by process are a special case in the catalogue of the ten novel food categories according to Article 3 (2) point (a) of the Novel Food Regulation (EU) 2015/2283, since the other nine categories derive their assessment as possible novel foods from their purely substantial properties. In the case of novel foods by process, the problem of dealing with the reference date of 15 May 1997, which is in the end a random reference date, is particularly significant. It would make more sense to have a dynamic reference date that ‘moves along the timeline’ or at least is reset from time to time and is more up-to-date. The characteristic that a process causes ‘significant changes in the composition or structure of the food, affecting its nutritional value, metabolism or level of undesirable substances’ must be understood in such a way that it is only a question of the generation of undesirable substances through the application of the process, but not their reduction, e.g. the reduction of undesirable microorganisms. Finally, the question also arises as to how the assessment of the process technology relates to the assessment of a food in the context of a novel food by composition category. This concerns the exemption for foods that have a history of use as safe foods, which, according to the view taken here, must also be interpreted into the category of novel foods by process.
Plant-based proteins are rapidly emerging, while novel technologies are explored to offer more efficient extraction processes. The current study aimed to evaluate the effects of pulsed electric fields (PEFs) and temperature on the extraction of soluble proteins from nettle leaves (Urtica dioica L.) and identify an optimal operational range for the highest yield of soluble proteins. Extractions and kinetic modeling were conducted with whole and ground dried leaves at different temperatures (30–70 °C) and specific energy of PEF (0–30 kJ kg−1) with extraction times of up to 60 min. The influence of temperature and specific energy on the soluble protein extraction yields was investigated and modeled using composite central design and response surface methodology. The experimental results were fitted to Peleg's kinetic model, which satisfactorily described the extraction process (R2 > 0.902), and PEF treated samples resulted in a higher soluble protein yield and shortened processing time. Response surface methodology showed that the linear effect of temperature and quadratic effect of PEF (p < 0.01) were highly significant for protein yield. In the optimized PEF-extraction region (specific energy between 10 and 24 kJ kg−1, and 70–78 °C), soluble protein yield was higher than 60% after 5 minutes of extraction. The achieved results are relevant for developing processes for PEF assisted extraction of soluble proteins from leaves. Understanding the effects of PEFs and process parameters is crucial to obtain high protein yields, while requiring low energy and short processing time.
Ohmic heating (OH) is an alternative sustainable heating technology that has demonstrated its potential to modify protein structures and aggregates. Furthermore, certain protein aggregates, namely amyloid fibrils (AF), are associated with an enhanced protein functionality, such as gelation. This study evaluates how Ohmic heating (OH) influences the formation of AF structures from ovalbumin source under two electric field strength levels, 8.5 to 10.5 and 24.0–31.0 V/cm, respectively. Hence, AF aggregate formation was assessed over holding times ranging from 30 to 1200 sunder various environmental conditions (3.45 and 67.95 mM NaCl, 80, 85 and 90 °C, pH = 7). AF were formed under all conditions. SDS-PAGE revealed that OH had a higher tendency to preserve native ovalbumin molecules. Furthermore, Congo Red and Thioflavin T stainings indicated that OH reduces the amount of AF structures. This finding was supported by FTIR measurements, which showed OH samples to contain lower amounts of beta-sheets. Field flow fractioning revealed smaller-sized aggregates or aggregate clusters occurred after OH treatment. In contrast, prolonged holding time or higher treatment temperatures increased ThT fluorescence, beta-sheet structures and aggregate as well as cluster sizes. Ionic strength was found to dominate the effects of electric field strength under different environmental conditions.
Olive oil holds significant importance in the European diet and is renowned globally for its sensory attributes and health benefits. The effectiveness of producing olive oil is greatly influenced by factors like the maturity and type of olives used, as well as the milling techniques employed. Generally, mechanical methods can extract approximately 80% of the oil contained in the olives. The rest 20% of the oil remains in the olive waste generated at the end of the process. Additionally, significant amounts of bioactive compounds like polyphenols are also lost in the olive pomace. Traditionally, heat treatment, enzymes, and other chemicals are used for the enhancement of oil extraction; however, this approach may impact the quality of olive oil. Therefore, new technology, such as pulsed electric field (PEF), is of great benefit for nonthermal yield and quality improvements.
Hintergrund
Die Anämie hat eine hohe Prävalenz bei Patienten vor Hüftgelenkrevisionsoperation und ist mit einer erhöhten Komplikationsrate assoziiert. Die vorliegende Arbeit untersucht erstmals den Zusammenhang von Kosten, realen DRG-Erlösen und Falldeckung der präoperativen Anämie bei elektiven Hüftgelenkrevisionsoperationen.
Methoden
Für alle Patienten, die sich von 2010 bis 2017 an 2 Campi der Charité – Universitätsmedizin Berlin einer Hüftgelenkrevisionsoperation unterzogen, wurden Daten zu Patienten sowie Transfusionen, Kosten und Erlösen gesammelt. Subgruppen- und lineare Regressionsanalysen untersuchten die Falldeckung anämischer und nichtanämischer Patienten.
Ergebnisse
Von 1187 eingeschlossenen Patienten waren 354 (29,8 %) präoperativ anämisch. Insgesamt wurden 565 (47,6 %) Patienten, mit einem deutlichen Überwiegen anämischer Patienten (72,6 % vs. 37,0 %, p < 0,001), transfundiert. Kosten (12.318 € [9027;20.044 €] vs. 8948 € [7501;11.339 €], p < 0,001) und Erlöse (11.788 € [8992;16.298 €] vs. 9611 € [8332;10.719 €], p < 0,001) waren für anämische Patienten höher, die Fallkostendeckung defizitär (−1170 € [−4467;1238 €] vs. 591 € [−1441;2103 €] €, p < 0,001). Bei anämischen Patienten nahm die Falldeckung mit zunehmender Transfusionsrate ab (p ≤ 0,001). Komorbiditäten hatten keinen signifikanten ökonomischen Einfluss.
Schlussfolgerung
Die präoperative Anämie und perioperative Transfusionen bei Hüftgelenkrevisionsoperationen sind mit erhöhten Behandlungskosten und einer finanziellen Unterdeckung für Kostenträger im Gesundheitswesen verbunden. Konzepte zur Behandlung der präoperativen Anämie (z. B. Patient Blood Management) könnten mittelfristig Behandlungskosten senken.
Introduction Postoperative delirium (POD) is seen in approximately 15% of elderly patients and is related to poorer outcomes. In 2017, the Federal Joint Committee (Gemeinsamer Bundesausschuss) introduced a ‘quality contract’ (QC) as a new instrument to improve healthcare in Germany. One of the four areas for improvement of in-patient care is the ‘Prevention of POD in the care of elderly patients’ (QC-POD), as a means to reduce the risk of developing POD and its complications.
The Institute for Quality Assurance and Transparency in Health Care identified gaps in the in-patient care of elderly patients related to the prevention, screening and treatment of POD, as required by consensus-based and evidence-based delirium guidelines. This paper introduces the QC-POD protocol, which aims to implement these guidelines into the clinical routine. There is an urgent need for well-structured, standardised and interdisciplinary pathways that enable the reliable screening and treatment of POD. Along with effective preventive measures, these concepts have a considerable potential to improve the care of elderly patients.
Methods and analysis The QC-POD study is a non-randomised, pre–post, monocentric, prospective trial with an interventional concept following a baseline control period. The QC-POD trial was initiated on 1 April 2020 between Charité-Universitätsmedizin Berlin and the German health insurance company BARMER and will end on 30 June 2023. Inclusion criteria: patients 70 years of age or older that are scheduled for a surgical procedure requiring anaesthesia and insurance with the QC partner (BARMER). Exclusion criteria included patients with a language barrier, moribund patients and those unwilling or unable to provide informed consent. The QC-POD protocol provides perioperative intervention at least two times per day, with delirium screening and non-pharmacological preventive measures.
Ethics and dissemination This protocol was approved by the ethics committee of the Charité-Universitätsmedizin, Berlin, Germany (EA1/054/20). The results will be published in a peer-reviewed scientific journal and presented at national and international conferences.
A brief questionnaire for measuring alarm fatigue in nurses and physicians in intensive care units
(2023)
When exposed to hundreds of medical device alarms per day, intensive care unit (ICU) staff can develop “alarm fatigue” (i.e., desensitisation to alarms). However, no standardised way of quantifying alarm fatigue exists. We aimed to develop a brief questionnaire for measuring alarm fatigue in nurses and physicians. After developing a list of initial items based on a literature review, we conducted 15 cognitive interviews with the target group (13 nurses and two physicians) to ensure that the items are face valid and comprehensible. We then asked 32 experts on alarm fatigue to judge whether the items are suited for measuring alarm fatigue. The resulting 27 items were sent to nurses and physicians from 15 ICUs of a large German hospital. We used exploratory factor analysis to further reduce the number of items and to identify scales. A total of 585 submissions from 707 participants could be analysed (of which 14% were physicians and 64% were nurses). The simple structure of a two-factor model was achieved within three rounds. The final questionnaire (called Charité Alarm Fatigue Questionnaire; CAFQa) consists of nine items along two scales (i.e., the “alarm stress scale” and the “alarm coping scale”). The CAFQa is a brief questionnaire that allows clinical alarm researchers to quantify the alarm fatigue of nurses and physicians. It should not take more than five minutes to administer.
Introduction: Patients undergoing revision total hip surgery (RTHS) have a high prevalence of mild and moderate preoperative anemia, associated with adverse outcomes. The aim of this study was to investigate the association of perioperative allogeneic blood transfusions (ABT) and postoperative complications in preoperatively mild compared to moderate anemic patients undergoing RTHS who did not receive a diagnostic anemia workup and treatment before surgery. Methods: We included 1,765 patients between 2007 and 2019 at a university hospital. Patients were categorized according to their severity of anemia using the WHO criteria of mild, moderate, and severe anemia in the first Hb level of the case. Patients were grouped as having received no ABT, 1–2 units of ABT, or more than 2 units of ABT. Need for intraoperative ABT was assessed in accordance with institutional standards. Primary endpoint was the compound incidence of postoperative complications. Secondary outcomes included major/minor complications and length of hospital and ICU stay. Results: Of the 1,765 patients, 31.0% were anemic of any cause before surgery. Transfusion rates were 81% in anemic patients and 41.2% in nonanemic patients. The adjusted risks for compound postoperative complication were significantly higher in patients with moderate anemia (OR 4.88, 95% CI: 1.54–13.15, p = 0.003) but not for patients with mild anemia (OR 1.93, 95% CI: 0.85–3.94, p < 0.090). Perioperative ABT was associated with significantly higher risks for complications in nonanemic patients and showed an increased risk for complications in all anemic patients. In RTHS, perioperative ABT as a treatment for moderate preoperative anemia of any cause was associated with a negative compound effect on postoperative complications, compared to anemia or ABT alone. Discussion: ABT is associated with adverse outcomes of patients with moderate preoperative anemia before RTHS. For this reason, medical treatment of moderate preoperative anemia may be considered.
Background
Beta-blocker (BB) therapy plays a central role in the treatment of cardiovascular diseases. An increasing number of patients with cardiovascular diseases undergoe noncardiac surgery, where opioids are an integral part of the anesthesiological management. There is evidence to suggest that short-term intravenous BB therapy may influence perioperative opioid requirements due to an assumed cross-talk between G-protein coupled beta-adrenergic and opioid receptors. Whether chronic BB therapy could also have an influence on perioperative opioid requirements is unclear.
Methods
A post hoc analysis of prospectively collected data from a multicenter observational (BioCog) study was performed. Inclusion criteria consisted of elderly patients (≥ 65 years) undergoing elective noncardiac surgery as well as total intravenous general anesthesia without the use of regional anesthesia and duration of anesthesia ≥ 60 min. Two groups were defined: patients with and without BB in their regular preopreative medication. The administered opioids were converted to their respective morphine equivalent doses. Multiple regression analysis was performed using the morphine-index to identify independent predictors.
Results
A total of 747 patients were included in the BioCog study in the study center Berlin. 106 patients fulfilled the inclusion criteria. Of these, 37 were on chronic BB. The latter were preoperatively significantly more likely to have arterial hypertension (94.6%), chronic renal failure (27%) and hyperlipoproteinemia (51.4%) compared to patients without BB. Both groups did not differ in terms of cumulative perioperative morphine equivalent dose (230.9 (BB group) vs. 214.8 mg (Non-BB group)). Predictive factors for increased morphine-index were older age, male sex, longer duration of anesthesia and surgery of the trunk. In a model with logarithmised morphine index, only gender (female) and duration of anesthesia remained predictive factors.
Conclusions
Chronic BB therapy was not associated with a reduced perioperative opioid consumption.
Die vollständig überarbeitete Neuauflage des Lehrbuchklassikers jetzt ergänzt durch ein zusätzliches Kapitel und mit neuem Layout.
Dieses Standardwerk umfasst sämtliche Themengebiete der Lebensmittelphysik und behandelt u. a. die thermischen, rheologischen, akustischen und elektrischen Eigenschaften sowie die Dichte und Textur von Lebensmitteln. Zudem wird ausführlich auf die Funktion von online-Sensoren und deren Bedeutung für die Prozessautomatisierung in der Lebensmittelindustrie eingegangen.
Für Studierende der Lebensmittelwissenschaften und der Lebensmitteltechnologie ist dieses Lehrbuch mit vielen vorgerechneten Beispielen die Basis für ein grundlegendes Verständnis der Lebensmittelphysik. Ingenieure, Technologen und Techniker in der Lebensmittelproduktion können die aufgelisteten Anwendungsbeispiele am Ende jedes Kapitels nutzen, um ihre Kenntnisse für zukünftige physikalische Verfahren zu vertiefen.
This textbook provides a comprehensive foundation of food physics by addressing the physical properties of food, food ingredients, and their measurements. Physical properties of food play a key role in all fields where modern technological processes are applied for the generation of food raw materials and the production of food. The determination of the physical properties of food and related products is a pre-requisite for product and process development, production engineering and automation in today’s food, pharmaceutical and cosmetics industries, as well as related quality control activities.
Following the success of its first edition published in 2007, the book has been updated to reflect recent industrial applications of novel physical food processing technologies. Each chapter begins with basic principles and progresses to a comprehensive coverage of the topic. The authors enriched this second edition with several didactic elements, including definition boxes, examples, and chapter-end summaries.
This textbook helps readers to build up their knowledge of the important aspects surrounding the physical properties of foods and food ingredients. It is also an essential resource for students of food science and technology to complement textbooks in food chemistry and food microbiology, as well as for food and chemical engineers, technologists, and technicians in the food industry.
Innovationen sind die stärksten Gestaltungsfaktoren für eine neue vielversprechende Zukunft, da sie die wichtigsten Treiber für Wachstum und Ertrag in unserer Wirtschaft sind. Die aktuelle Zeitenwende zeigt uns sehr deutlich, dass wir ohne Innovationen bzw. Veränderungen und Anpassungen kaum noch wettbewerbsfähig bleiben, sowohl als Nation bzw. als Gesellschaft und insbesondere als Unternehmen.
Die hohe Dynamik und Komplexität der wirtschaftlichen und sozialen Prozesse setzt neue Maßstäbe an die Innovationsstrategien von Institutionen und Unternehmen.
Neue Technologien, neue Märkte, neues Kundenverhalten und der stetige Wandel sowohl in der Arbeitswelt als auch in unserem gesellschaftlichen Umfeld, wie z.B. die Digitalisierung, zeigen uns, dass allein eine Produktinnovation als solche heute nicht mehr ausreicht. Unter den genannten Randbedingungen müssen Innovationen auch in der Gestaltung von Geschäftsprozessen und Realisierung der "Work-Life-Balance" neu erdacht bzw. überprüft werden.
Der Vorsprung innovativer Produkte im viralen Wettbewerb ist oft nur kurz. Ein ganzheitliches Innovationsmanagement hat alle Bereiche des Unternehmens einzubeziehen und führt zu neuen Geschäftsmodellen, die etablierte Geschäftspraktiken verdrängen, ebenso tauchen durch neue Technologien in immer stärkerem Maße neue Anbieter auf, die die Spielregeln in den Märkten verändern.
Der 1. Deutsche Innovations-Kongress will Impulse setzen, Best-Practice-Modelle als Vorbilder anbieten und im Austausch zwischen den Referent*innen und den Teilnehmer*innen neue Wege bzw. Perspektiven eröffnen.
Wir freuen uns auf alle Teilnehmer*innen und den Erfahrungsaustausch, um aktuelle und nachhaltige Innovations-Impulse zu setzen und neue Wege erfolgversprechende Wege zu beschreiben, womit die bereits fruchtbaren Kooperationen zwischen Wirtschaft und Wissenschaft im Großraum Osnabrück noch weiter belebt werden soll.
Aktuell tragen auch 8 Studierendengruppen des Masterstudiengangs "Entwicklung und Produktion" der Hochschule Osnabrück in der Fakultät I u. I im Rahmen des Moduls "Innovationsmanagement" in Kooperation mit Unternehmen aus der Region durch die Entwicklung neuer innovativer Produkte zum Erfolg des Kongresses bei. Die Zwischenergebnisse dazu werden in einer Poster-Ausstellung präsentiert. Die Innovationsprojekte werden unter der Leitung von Prof. Dr. Jens Schäfer durchgeführt.
Quo vadis Oecotrophologie?
(2021)
Die Entscheidung für eine Teilzeitbeschäftigung von examinierten Pflegekräften gewinnt in der Bundesrepublik Deutschland zunehmend an Bedeutung. Dieses Thema ist von zentraler Relevanz, da es zwangsläufig eine kritische Auseinandersetzung mit den Arbeitsbedingungen im Gesundheitswesen, der Sicherstellung des gesellschaftlichen Versorgungsauftrages sowie der Berücksichtigung der sich verändernden Lebensrealitäten der in der Pflege tätigen Fachkräfte erfordert. Ziel dieser Forschungsarbeit ist es, eine methodische Annäherung an das Phänomen der individuellen Entscheidungsprozesse von examinierten Pflegekräften in Bezug auf ein reduziertes Arbeitszeitmodell darzustellen. Zu diesem Zweck wird eine literaturgestützte empirische Untersuchung in Form von Experteninterviews mit beruflich Pflegenden durchgeführt. Besonderes Augenmerk wird dabei auf die subjektiven Erfahrungen und Sichtweisen der Interviewpartner gelegt. Die gewonnenen Erkenntnisse dienen dazu, eine vergleichende Analyse mit den Ergebnissen aus der einschlägigen Literatur durchzuführen. Abschließend erfolgt die Darstellung aktueller Entwicklungen innerhalb des Pflegeberufes sowie die Diskussion zukunftsfähiger Ansätze hinsichtlich der Arbeitsbedingungen.
Iron deficiency is still widespread as a major health problem even in countries with adequate food supply. It mainly affects women but also vegans, vegetarians, and athletes and can lead to various clinical pictures. Biofortification of vitamin C-rich vegetables with iron may be one new approach to face this nutritional challenge. However, so far, little is known about the consumer acceptance of iron-biofortified vegetables, particularly in developed countries. To address this issue, a quantitative survey of 1000 consumers in Germany was conducted. The results showed that depending on the type of vegetable, between 54% and 79% of the respondents were interested in iron-biofortified vegetables. Regression analysis showed a relationship between product acceptance, gender, and area of residence. In addition, relationships were found between consumer preferences for enjoyment, sustainability, and naturalness. Compared to functional food and dietary supplements, 77% of respondents would prefer fresh iron-rich vegetables to improve their iron intake. For a market launch, those iron-rich vegetables appear especially promising, which can additionally be advertised with claims for being rich in vitamin C and cultivated in an environmentally friendly way. Consumers were willing to pay EUR 0.10 to EUR 0.20 more for the iron-biofortified vegetables.
Hintergrund
Demografisch bedingt wird sich die Anzahl pflegebedürftiger Menschen weiter erhöhen. Tragende Säule der pflegerischen Versorgung sind ihre Angehörigen, die den Großteil der Pflegeaufgaben übernehmen. Dies hat jedoch oftmals Auswirkungen auf ihre eigene Gesundheit und ihr Wohlbefinden.
Methodisches Vorgehen
Mit dem Fragebogen zur Angehörigenresilienz und -belastung (FARBE) liegt ein Instrument vor, um sowohl die Resilienz als auch Belastung pflegender Angehöriger zu ermitteln. Der Fragebogen wurde im Rahmen der Pflegestudie des VdK-Sozialverbands genutzt und von 12.475 Angehörigen komplett ausgefüllt. Durch eine multiple lineare Regression wurden Einflüsse und ihre Wirkstärke auf die Resilienz und Belastung analysiert.
Ergebnisse
Angehörige von Menschen mit Demenz, Depression oder hohem Pflegegrad weisen eine stärkere Belastung auf. Demenz und Depression mindern zudem die Resilienz. Positiv wirkt sich die soziale Unterstützung aus. Ebenso bedingt ein höheres Alter eine stärkere Resilienz.
Schlussfolgerungen
Im Ergebnis dieser Arbeit gelang eine Identifikation von relevanten Einflussfaktoren. Dies ermöglicht, Unterstützungs- und Entlastungsangebote auf ihre Anwendung und Wirksamkeit zu überprüfen. Besondere Bedeutung haben Unterstützungsangebote für Angehörige von Menschen mit Demenz, Depression und/oder höheren Pflegegraden. Stressreduzierende Maßnahmen und das Bilden sozialer Netzwerke für Angehörige können weitere Maßnahmen zur Stärkung der Resilienz und Abschwächung von Belastung sein.
Der vorliegende Bericht fasst die Ergebnisse der durch den Sozialverband VdK in Auftrag gegebenen Pflegestudie „Wunsch und Wirklichkeit in der häuslichen Pflege“ zusammen. Viele Menschen haben dazu beigetragen, dass die Studie durchgeführt werden konnte. An erster Stelle und vor allem sei den Menschen herzlich gedankt, die sich an der Befragung beteiligt haben. Mehr als 50.000 Teilnehmerinnen und Teilnehmer haben jegliche Erwartung zur Teilnahme an der Studie deutlich übertroffen.
In Deutschland werden 80% der auf Pflege angewiesenen Menschen im häuslichen Umfeld versorgt, 56 % davon aufgrund sozialer Beziehungen ausschließlich von informell pflegenden Personen. Die Anzahl häuslicher Pflegearrangements steigt seit Jahren kontinuierlich bei bereits erreichter Kapazitätsgrenze existierender ambulanter Dienste. Um einen Beitrag zum wissenschaftlichen Verständnis pflegerischer Versorgung im häuslichen Setting zu leisten, wurden insgesamt 18 narrative Interviews zu Wunsch und Wirklichkeit häuslicher Pflege mit pflegebedürftigen und pflegenden Personen sowie zwei Expert*innen geführt und nach den Prinzipien der Grounded Theory ausgewertet. Die entwickelte Akzeptanztheorie bietet einen grundsätzlichen Erklärungsansatz informeller Pflege und verweist auf die dringliche und unabdingbar notwendige Weiterentwicklung ambulanter Versorgungsstrukturen, sollen Pflegearrangements in großer Anzahl weiterhin Bestand haben.
Einleitung
Die Prävalenz der über 80-jährigen bei Ulcus cruris venosum (VLU) beträgt 4-5 %, obwohl diese Altersgruppe nur 1 % der Gesamtbevölkerung ausmacht. Zusätzlich wird bei VLU-Patienten häufig eine Mangelernährung beobachtet. Insbesondere geriatrische Patienten leiden darunter. Dabei ist bekannt, dass Mangelernährung Einfluss auf die Wundheilung und somit auf die Lebensqualität der Patienten hat. Diverse Studien beschreiben erste erfolgreiche ernährungstherapeutische Ansätze für einen beschleunigten Wundheilungsprozess. Allerdings ist die Ernährungstherapie bei VLU-Patienten wenig erforscht. Ziel dieser Arbeit ist es einen Überblick über den ernährungsphysiologischen Einfluss zur VLU zu schaffen, um mögliche Ernährungsinterventionen für geriatrische Patienten zu erhalten.
Methods: The searches were conducted on five electronic databases. RCTs or CTs with patients over 18 years old of both sexes with OFP diagnoses were targeted. The intervention of interest was AE (i.e., walking, cycling, and running), compared to any other conservative and non-conservative therapy. The primary outcome was pain intensity. Risk of bias (RoB) was done with the Cochrane RoB tool (RoB 2). The overall certainty of the evidence was evaluated with GRADE.
Results: Out of 21,585 initial records found in the initial database search, only one study (reported on three manuscripts) was included. The diagnosis of interest was headache plus temporomandibular disorders (TMD). Three treatment groups (strengthening (Str) exercise + manual therapy (MT) (G1); AE + MT + Str exercises (G2); AE (G3)) were compared. The main outcome was pain; the secondary outcomes included disability, strength, anxiety, and quality of life. The combined treatment (AE+MT+Str exercises) had the strongest effect to decrease pain and headache intensity in patients with OFP (SMD: 9.99 [95%CI: 7.19, 12.80].
Conclusions: a multimodal treatment strategy achieved the greatest positive effects on pain and other outcomes in the short/medium term. AE seems to be an important component of this strategy. However, the scientific evidence supporting AE’s isolated effect is limited, indicating a research gap in this scientific field.
Sängerinnen und Sänger gehören zu der Gruppe der sogenannten „Professional Voice User“ bzw. der BerufssprecherInnen. Diese Gruppe ist den höchsten Anforderungen hinsichtlich der Stimmqualität und der Stimmbelastung ausgesetzt. Deshalb haben SängerInnen ein hohes Risiko eine Stimmstörung zu entwickeln, die wiederum ihre Arbeitsfähigkeit und Lebensqualität beeinträchtigen kann. Neben Stimmstörungen mit organischen Ursachen gibt es funktionelle Stimmstörungen, die z.B. durch ein ungünstiges Atemmuster oder Hypertonus der Schulter-, Nacken- und Halsmuskulatur verursacht werden können. In diesem Vortrag werden die unterschiedlichen Risikofaktoren für die Entwicklung einer Stimmstörung bei SängerInnen aufgezeigt. Anschließend werden physiotherapeutische Behandlungsansätze vorgestellt, die als Teil eines multidisziplinären Managements von funktionellen Stimmstörungen bei SängerInnen eingesetzt werden können.
Background: Singers belong to the group of professional voice users with the highest demands regarding voice quality and vocal load. Thus, they also have a high risk of developing a voice disorder, which in return has major impact on their ability to work. Besides voice disorders caused by organic changes, there are functional voice disorders caused by, e.g., a hypertonia of the larynx, shoulder and neck muscles or insufficient breathing patterns. In these cases, physiotherapy can be one component of a multidisciplinary approach to treatment.
The purpose of this presentation is, based on anatomical considerations and current evidence, to inform about and demonstrate physiotherapy techniques for treating singers with functional voice disorders.
Approach of Presentation: A case from a special physiotherapy outpatient clinic for vocalists will be described. Based on this example, information on the evidence of physiotherapy approaches for functional voice disorders will be provided. Afterwards, some practical hands-on techniques will be demonstrated for participants to try.
Content of Presentation: This workshop will focus on the physiotherapy treatment for a vocalist with functional voice disorders. The vocalist experienced changed pitch and hypertonia in both the muscles of the shoulder-neck region and the extrinsic laryngeal muscles. Paralaryngeal manual techniques, in addition to posture and breathing exercises, will be demonstrated with the purpose of mobilizing the larynx and relaxing the hypertonic muscles.
Conclusions and Practical Relevance: This workshop highlights the special potential of physical therapy in the treatment of functional voice disorders in singers.
Ziel des Workshops ist es, das besondere Potential der Physiotherapie im multidisziplinären Management von Sängerinnen und Sängern mit funktionellen Stimmstörungen aufzuzeigen. Anhand eines Fallbeispiels aus der physiotherapeutischen Musikersprechstunde wird der physiotherapeutische Behandlungsansatz vorgestellt. Die Sängerin mit ärztlich diagnostizierter hyperfunktioneller Stimmstörung zeigte Symptome wie ein sternales Atemmuster und Hypertonus der Nacken-, Kiefer- und der äußeren Kehlkopf-Muskulatur. Basierend auf der aktuellen Evidenzlage und der Anatomie werden die theoretischen Überlegungen der klinischen Urteilsbildung erläutert. Das Vorgehen im Behandlungsprozess wird beschrieben und einige praktische Beispiele von Behandlungstechniken, z.B. manualtherapeutische Techniken am Kehlkopf, werden demonstriert.
Körperhaltung und Muskelspannung beeinflussen den Klang der Stimme. Aber gibt es auch einen Zusammenhang zwischen der motorischen Kontrolle der Nacken-, Gesichts- und Kieferregion und der Stimme? Die Pilotstudie mit 12 Sängerinnen ging dieser Frage nach und zeigt: Es ist sinnvoll, die motorische Kontrolle zu testen, wenn Patient*innen mit Stimmproblemen zur Physiotherapie kommen.
Objectives:
The purpose of this study was to determine the motor function of the abdominal muscles in singers with and without functional voice disorders and to examine them for possible differences. Additionally, the breathing behaviour and posture control was investigated.
Study Design
Observational study.
Methods:
Female subjects (n = 20) with differing levels of professional competence were used to provide the data for analysis. By using the Singing Voice Handicap Index (SVHI) the grade of dysphonia could be measured, and the subjects were organized in groups. The change of muscle thickness of the M. transversus abdominis (TVA) and the M. obliquus internus abdominis (OIA) during different singing tasks was measured by using ultrasound. The subjects were then asked to perform the Abdominal Hollowing Test (AHT) with the STABILIZER. Finally, the subjects were all filmed while singing. The videos recordings of the singing sessions were analysed by an independent clinical expert regarding breathing and secondary motor activities (SMA). For the statistical analysis, the Mann-Whitney-U Test and the Chi-Square-Test was mainly used.
Results:
The results showed a significantly thinner TVA in the group with dysphonia in comparison to the group without dysphonia. Ultrasound measurements showed significantly higher changes of muscle thickness of the TVA during singing tasks in the group with dysphonia. Regarding the AHT there was a significant difference between the two groups. The group with dysphonia was not able to increase the pressure by 15mmHg. Furthermore, the healthy subjects demonstrated abdominal breathing, while the group with dysphonia present with thoracic breathing. Additionally, it was noted that the subjects with dysphonia showed a higher level of associated movements especially at and/or on the lumbar spine, cervical spine and the left arm and shoulder.
Conclusion:
Differences in TVA-recruitment, breathing behaviour and secondary motor activities while singing were found. This study sparks new ideas for neuromusculoskeletal assessments and therapy.
Key Words
Transversus abdominis, Abdominal muscles, Dysphonia, Ultrasound, Singing voice, Singers
rationale: Musculoskeletal problems are widespread in performing artists and are due to the special demands of instrument playing, singing or dancing. Additionally, various other factors might contribute to performance-related musculoskeletal problems. In order to provide a specific physiotherapeutic management for performing artists, it is important to gain information about the performing art, the individual (biomechanical) demands and contributing factors. The subjective examination is the basis of the clinical reasoning process and the hypothesis forming, which is important for goal setting in further clinical examination and biomechanical analysis. In the present protocol, the subjective examination consists of a questionnaire based section and an interview based section and is part of the evaluation process of the neuromusculoskeletal examination of a performing artist specific reference laboratory.
purpose: The aim of this study was to develop a standardized protocol for an interview based subjective examination of performing artists with musculoskeletal problems. The results of this section of the subjective examination will be combined with the results of the questionnaire based subjective examination , in order to gather as much relevant information as possible to specifically address the individual’s musculoskeletal health status.
methods: A common physiotherapeutic recording of findings which addresses the relevant questions of the subjective examination of musculoskeletal problems was used. In order to adapt the anamnesis to performing-related musculoskeletal problems, questions specific to instrument playing, singing and dancing were selected on the basis of a literature search and the expertise of the research group.
results: The protocol is based on the five aspects of clinical practice described by Maitland and the Musculoskeletal Clinical Translation Framework by Mitchell et al. (2017) .The performing art specific questions especially address (1) performing art specific considerations including style, genre, education and professional level, practice habits, repertoire, and external factors, e.g. concert conditions, (2) performing art specific physical and psychosocial contributing factors, and (3) performing art specific activities which trigger the musculoskeletal problems and help to form hypotheses for the following clinical examination. Individual tracks lead through the subjective examination so that irrelevant questions are skipped depending on the kind of musculoskeletal problem and the performing art practiced by the individual client.
conclusions: A pretest of this standardized anamnesis protocol is ongoing in a special physiotherapy clinic for performing artists since spring 2022. In an iterative approach, the protocol will be continuously improved based on patient feedback and clinical considerations.
The aim of this European interprofessional Health Informatics (HI) Summer School was (i) to make advanced healthcare students familiar with what HI can offer in terms of knowledge development for patient care and (ii) to give them an idea about the underlying technical and legal mechanisms. According to the students’ evaluation, interprofessional education was very well received, problem-based learning focussing on cases was rated positively and the learning goals were met. However, it was criticised that the online material provided was rather detailed and comprehensive and could have been a bit overcharging for beginners. These drawbacks were obviously compensated by the positive experience of working in international and interprofessional groups and a generally welcoming environment.
Background and Aims
Early identification of nerve lesions and associated neuropathic pain in spine-related pain disorders is important for tailored treatment. Management may consist of surgical intervention for compressive neural lesions.
With a growing waitlist for public surgical outpatient clinics in Western Australia and wait times exceeding the recommended wait time for initial assessment (Category 1 – assessment within 1 months, Category 2 within 3 months, category 3 within 12 months), a call to support new models of care has been made1, including the evaluation and expansion of workforce models supporting advanced skills in allied health.1
An Advanced Scope Physiotherapy (ASP) led Neurosurgery Spinal Clinic operates at Sir Charles Gairdner Hospital in Western Australia. The ASPs (2FTE) examine patients from the neurosurgery waitlist for their suitability for spinal surgery. Recommendation of either further investigation and possible assessment by a neurosurgeon or appropriate non-surgical management of the patients’ pain condition is suggested. Patient assessment is conducted either ‘in person’ at the hospital or via telehealth due to the remoteness of some rural patients. Patient cases are discussed with a neurosurgery consultant on a weekly basis. The aim of this project is to evaluate the ASP service in the year 2022.
Method
A retrospective descriptive analysis of patient data captured in 2022 was performed.
Results
In 2022, 1337 new patient referrals were managed plus 267 follow-ups from the previous year. Category 1 patients (n=81) waited on average 31 days for their first appointment, Category 2 patients (n=394) waited 76 days and Category 3 patients (n=854) waited 376 days.
287 (18%) referrals were discharged without physical assessment of the patient (DNA, cancellations, declined). Of the 1317 patients physically assessed by the ASPs (57%) were discharged directly after assessment, for 290 patients (22%) their outcome was still pending at time of analysis (March 2023) and 281 (22%) patients were referred for review with a neurosurgeon. Of the 229 patients assessed by a neurosurgeon (including patients from 2022), 103 patients (45%) were offered surgery, 52 (23%) were not offered surgery, 46 ( 20%) patients had to be reviewed, and for the remaining (n=18) their outcome was unknown.
Conclusion
Of the 1604 patients managed in the Neurosurgery Spinal Clinic, only 17% needed to see a neurosurgeon. The conversion rate to surgery of 45% is higher compared to an estimated 5%-10% in a non-triaged clinic.
The ASP model of care has proved invaluable to (i) provide access of patient care within the recommended wait times (ii) optimize neurosurgeons’ time, (iii) educate patients and, in case of non-suitability for surgery, advise and refer them for alternative appropriate management.
Relevance for Patient Care
The Advanced Scope Physiotherapy model of care at the Neurosurgery Spinal Clinic allows timely assessment of patients with spine-related disorders and supports targeted management of their condition.
Ethical Permissions
This project is registered as a Quality Improvement Project at Sir Charles Gairdner Hospital (QI35728) and as per the National Statement on Ethical Conduct in Human Research was exempt from review by the Sir Charles Gairdner Hospital Human Research and Ethics Committee
References
1Sustainable Health Review (2019). Sustainable Health Review: Final report to the Western Australian Government of Health, Western Australia
Workshop: “‘Sciatica’: neuropathic or not and does it matter? Outcomes from a NeuPSIG working group”
(2023)
The identification of neuropathic pain in persons with spine-related leg pain is important as this information guides treatment and management, including self-management. The NeuPSIG neuropathic pain grading system was developed to assist clinicians and researchers in determining whether patients have neuropathic pain and the level of confidence associated with that decision. Based on clinical and laboratory examination findings, patients are classified as having no neuropathic pain, possible, probable or definite neuropathic pain. Whereas this grading system works nicely in people with systemic neuropathies where sensory findings and diagnostic tests are mostly present, its application in patients with spine-related leg pain, particular in radicular pain, can be challenging. For example, in the absence of sensory changes and MRI findings, patients with radicular pain would at best reach a classification of possible neuropathic pain according to the current neuropathic pain grading system.
In this presentation I will explain the adaptations to the neuropathic pain grading system for spine-related leg pain recommended by the NeuPSIG working group. I will demonstrate its application in clinical practice using case studies and provide clarity for how the system can be incorporated in clinical trials. This will be an interactive session with audience participation.
Purpose
Sedentary behaviour (SED) and low level of physical activity (PA) might be associated with the development or worsening of pain. Still, studies assessing physical behaviours by accelerometry in individuals with orofacial pain are limited. This study aims to assess whether women with temporomandibular disorders (TMD) present different patterns of physical behaviours in days with (DWP) or without pain (DWoP).
Methods
Twenty-nine out of forty-four women (mean age 29.21 sd 7.96) were diagnosed with TMD and monitored over seven days using a thigh-worn accelerometer. DWP was determined when subjects presented pain in one of the craniocervical regions (head, jaw and neck) with intensity of at least 3 in the numerical rating scale. To be considered a DWoP, the individual presented less than 3 points in the three regions. Daily time-use compositions were described in terms of SED in short (<30 min) and long (≥30 min) bouts, light PA (LPA), moderate-to-vigorous PA (MVPA), and time-in-bed. Isometric log-ratios (ilr) were calculated to express the ratio of time-in-bed to time spent awake, SED relative to LPA and MVPA, SED in short relative to long bouts, and LPA relative to MVPA. Differences between DWP and DWoP were examined using MANOVA, followed by univariate post-hoc tests of pairwise differences.
Results
During DWP, women with TMD spent more time in SED in short (239 min) and long bouts (419 min), less time in LPA (245 min), MVPA (68 min), and in bed (468 min) compared with DWoP (235, 378, 263, 70 and 493 min, respectively). The MANOVA showed that all sets of ilrs did not differ statistically (ηp2 = 0.19, p = 0.25). Still, the post-hoc tests showed a trend that time spent SED relative to LPA and MVPA was larger in DWP than in DWoP (Cohen’s d = 0.36, p = 0.05).
Conclusions
Women with TMD did not show different patterns of physical behaviours in DWP or DWoP. However, there is a trend of more sedentary behaviour and less physical activity in DWP compared to DWoP. Future studies should consider other pain intensity cut-offs, isolated pain locations, and larger sample sizes to confirm these results.
Wie sieht die Essensversorgung von Senioren in der Zukunft aus? : Zukunftsstudie Menüservice 2025
(2016)
Der vorliegende Beitrag** überprüft anhand der Ergebnisse eines Discrete-ChoiceExperimentes die Wirkung eines noch unbekannten „Mykotoxin frei“-Zeichens auf die Kaufentscheidung des Verbrauchers bei Weizenmehl. Da anzunehmen ist, dass ein Großteil der Verbraucher mit der Mykotoxinproblematik wenig vertraut ist, wird weitergehend der Einfluss von Zusatzinformationen, die das Mykotoxinrisiko in verharmlosender oder verschlimmernder Weise darstellen, getestet. Um weitere Handlungsempfehlungen zur Etablierung eines „Mykotoxin frei“-Zeichens geben zu können, werden darüber hinaus Wechselwirkungen zwischen dem Label und verschiedenen Marken (Herstellermarke, Handelsmarke, BiolandMarke) untersucht.
Um die Ausgaben der gesetzlichen Krankenversicherung in Deutschland zu senken, wurde mit dem GKV-Finanzstabilisierungsgesetz neben anderen Maßnahmen die Aufhebung der Neupatientenregelung zum Jahresbeginn 2023 durchgesetzt. In politischen Kreisen wurde die Aufhebung der Regelung unter Verweis auf einen erschwerten Patientenzugang im ambulanten Sektor teils deutlich kritisiert. Um zu überprüfen, wie es um die Bereitschaft zur Aufnahme von Neupatienten nach Aufhebung der Neupatientenregelung bestellt ist, wurden im Rahmen einer randomisierten empirischen Feldstudie im Zeitraum von März bis April 2023 insgesamt 180 niedersächsische Hausärzte angerufen. Dabei gab sich der Studienautor als zugezogener Neupatient aus, der auf der Suche nach einem neuen Hausarzt sei. Da im Vorfeld eine schlechte telefonische Erreichbarkeit erwartet worden war, wurden jeder Arztpraxis bis zu drei Anrufversuche gewährt. Es zeigte sich, dass gut zwei Drittel der erreichten Praxen zur Aufnahme eines Neupatienten bereit sind. Außerdem konnte festgestellt werden, dass ein hoher regionaler Versorgungsgrad mit einer schlechten telefonischen Erreichbarkeit der Arztpraxen in Verbindung steht. Bezüglich der Organisationsformen und der Anzahl an Ärzten je Praxis konnten keine signifikanten Korrelationen festgestellt werden. Montags war die telefonische Erreichbarkeit der Praxen deutlich geringer als mittwochs und freitags. Die vorliegende Bachelorarbeit beschreibt die für die Studiendurchführung relevanten Grundlagen der hausärztlichen Versorgung in Deutschland, begründet die verwendete Methodik und diskutiert die Studienergebnisse.
Biomechanical analyses are capable of capturing and evaluating human motions. In addition to the major biomechanical fields of kinetics and kinematics, electromyography (EMG) provides a reliable way to analyse neuromuscular activities, e.g. inter- and intramuscular coordination or fatigue behavior. Based on these parameters it is possible to conclude to clinically relevant parameters such as motor control, muscular coordination or compensation strategies with different loads. In addition to this, EMG can be used in treatment itself, e.g. biofeedback-training with an EMG is an effective and evidenced based tool to improve neuromuscular control. The purpose of this workshop is to show the advantages of implementing EMG in performing artists´ health and to demonstrate additional therapy and diagnostic options.
This workshop briefly introduces the theoretical principles of EMG and the clinical applications in the context of performing artists´ health. It explains why EMG provides an additional value in the clinical reasoning process and supports the therapist, but decision making in the clinical reasoning process should never be based on EMG solely.
In the further course of the workshop the use of EMG in diagnostics and therapy (biofeedback) with performing artists is practically demonstrated and discussed with the participants.
Approach of Presentation:
1. Short presentation: introduction and understanding of EMG (educational objective 1)
2. Short case presentation of a performing artist to introduce EMG in the field of performing artists´ health and clinical reasoning (educational objective 2)
3. Interactive practical demonstration (diagnosis and biofeedback-training) as the central part of the workshop. Questions and comments will be discussed directly throughout the group (educational objective 3)
Clinical Significance:
EMG based functional neuromuscular diagnostics and biofeedback-training provides both the therapist as well as the performing artist with additional value in their clinical work.
Educational Objectives:
At the end of the workshop, the participants will be able to…
1. understand and describe the basic principles of EMG
2. understand and describe the importance of EMG in the context of performing artists´ health, physical therapy and clinical reasoning
3. use EMG on performing artists in the performance process
Hintergrund und Zielsetzung:
Instrumentalistinnen und Instrumentalisten sind beim Spielen erheblichen psychischen und Instrument-spezifischen körperlichen Belastungen ausgesetzt. Häufig kommt es dabei zu Überlastungen des neuromuskuloskelettalen Systems, insbesondere der oberen Extremität. Welchen Beitrag kann eine musikerspezifische Physiotherapie zum Management von körperlichen spielbedingten Beschwerden leisten?
Methodik:
Es wurde eine Literaturrecherche zu Art und Prävalenz neuromuskuloskelettaler Beschwerden der oberen Extremität bei Instrumentalist/innen durchgeführt. Zusätzlich wurden retrospektiv Patient/innen-Akten aus einer physiotherapeutischen Musiker/innen-Sprechstunde gesichtet, um das Vorgehen bei der Untersuchung und Behandlung spielbedingter Beschwerden zu beschreiben.
Ergebnisse:
Studien berichten von einer Prävalenz spielbedingter neuromuskuloskelettaler Beschwerden der oberen Extremität bei Instrumentalist/innen von 47-52,8%. Häufige Ursachen sind Überlastungssyndrome durch wiederkehrende Belastung derselben anatomischen Strukturen, Hypo- oder Hypermobilität sowie (periphere) Neuropathien. Bei der physiotherapeutischen Anamnese bei Instrumentalist/innen spielen sowohl Beschwerde-bezogene Fragen als auch spezifische Fragen zum Instrument, zur Spielerfahrung und zum Übeverhalten eine wichtige Rolle. Insbesondere die funktionelle Demonstration der beschwerdeauslösenden Bewegung und die Haltungs-/Bewegungsanalyse am Instrument geben wichtige Hinweise für das weitere Vorgehen in der physiotherapeutischen Diagnostik und Behandlung. Die klinische Untersuchung kann durch eine apparative Untersuchung z.B. der Muskelaktivität und von Bewegungsabläufen ergänzt werden. Die physiotherapeutischen Behandlungsansätze beinhalten Manuelle Therapie, (Instrument-)spezifische therapeutische Übungen, Haltungs-/Bewegungsschulung am Instrument, neurodynamische Techniken und Patient/innen-Edukation sowie ergonomische Anpassungen des Instruments.
Schlussfolgerung:
Eine musikerspezifische physiotherapeutische Versorgung kann einen entscheidenden Beitrag zum multidisziplinären Management spielbedingter neuromuskuloskelettaler Beschwerden der oberen Extremität bei Instrumentalist/innen leisten.
Hintergrund
Negatives Geburtserleben steht im Verdacht mit nachfolgender Sterilität, einem längeren Abstand zum nächsten Kind, sowie dem Wunsch nach einer primären Sectio bei einer weiteren Schwangerschaft assoziiert zu sein. Die derzeitige Datenlage ist kontrovers.
Methodisches Vorgehen
Das Design entspricht einer explorativen, qualitativen Querschnittsstudie. Dazu wurden zehn leitfadengestützte Interviews nach dem Prinzip des Problemzentrierten Interviews durchgeführt. Eingeschlossen wurden Primiparae, die vor dem 11.03.2020 (vor den Einschränkungen der Covid-19-Pandemie) geboren haben. Die Interviews wurden nach der inhaltlich strukturierenden qualitativen Inhaltsanalyse nach Kuckartz analysiert.
Ergebnisse
Insbesondere Frauen mit negativem Geburtserleben tendieren zu einer abgeschwächten Bereitschaft für eine weitere Schwangerschaft, dazu keine weitere Schwangerschaft zu planen sowie einen längeren Abstand zu einer weiteren Schwangerschaft zu wahren. Nur in Einzelfällen kann bei Frauen mit positiver Geburtserfahrung eine verstärkte Bereitschaft für eine weitere Schwangerschaft festgestellt werden. Die Entscheidung bezüglich der Planung einer Schwangerschaft ist multifaktoriell und sowohl vom Geburtserleben als auch von persönlichen, medizinischen, familiären und finanziellen Aspekten abhängig.
Diskussion
Besonders das Auftreten medizinischer Besonderheiten, das negative Erleben des Geburtsmodus, der peripartalen Schmerzen sowie der Betreuung und Versorgung scheinen Einflussfaktoren zu sein, welche die Bereitschaft für die Planung einer weiteren Schwangerschaft abschwächen. Es besteht weiterer Forschungsbedarf durch quantitative Arbeiten und in der Begriffsdefinition von Geburtserleben.
Fazit
Das individuelle Geburtserleben von Primiparae kann einen Einfluss auf die Planung einer weiteren Schwangerschaft haben.
Studies on nutrition have historically concentrated on food-shortages and over-nutrition. The physiological states of feeling hungry or being satiated and its dynamics in food choices, dietary patterns, and nutritional behavior, have not been the focus of many studies. Currently, visual analytic using easy-to-use tooling offers applicability in a wide-range of disciplines. In this interdisciplinary pilot-study we tested a novel visual analytic software to assess dietary patterns and food choices for greater understanding of nutritional behavior when hungry and when satiated. We developed software toolchain and tested the hypotheses that there is no difference between visual search patterns of dishes 1) when hungry and when satiated and 2) in being vegetarian and non-vegetarian. Results indicate that food choices can be deviant from dietary patterns but correlate slightly with dish-gazing. Further, scene perception probably could vary between being hungry and satiated. Understanding t he complicated relationship between scene perception and nutritional behavioral patterns and scaling up this pilot-study to a full-study using our introduced software approaches is indispensable.
Chitin is an abundant waste product from shrimp and mushroom industries and as such, an appropriate secondary feedstock for biotechnological processes. However, chitin is a crystalline substrate embedded in complex biological matrices, and, therefore, difficult to utilize, requiring an equally complex chitinolytic machinery. Following a bottom-up approach, we here describe the step-wise development of a mutualistic, non-competitive consortium in which a lysine-auxotrophic Escherichia coli substrate converter cleaves the chitin monomer N-acetylglucosamine (GlcNAc) into glucosamine (GlcN) and acetate, but uses only acetate while leaving GlcN for growth of the lysine-secreting Corynebacterium glutamicum producer strain. We first engineered the substrate converter strain for growth on acetate but not GlcN, and the producer strain for growth on GlcN but not acetate. Growth of the two strains in co-culture in the presence of a mixture of GlcN and acetate was stabilized through lysine cross-feeding. Addition of recombinant chitinase to cleave chitin into GlcNAc2, chitin deacetylase to convert GlcNAc2 into GlcN2 and acetate, and glucosaminidase to cleave GlcN2 into GlcN supported growth of the two strains in co-culture in the presence of colloidal chitin as sole carbon source. Substrate converter strains secreting a chitinase or a β-1,4-glucosaminidase degraded chitin to GlcNAc2 or GlcN2 to GlcN, respectively, but required glucose for growth. In contrast, by cleaving GlcNAc into GlcN and acetate, a chitin deacetylase-expressing substrate converter enabled growth of the producer strain in co-culture with GlcNAc as sole carbon source, providing proof-of-principle for a fully integrated co-culture for the biotechnological utilization of chitin.
High levels of meat consumption are increasingly being criticised for ethical, environmental, and social reasons. Plant-based meat substitutes have been with reservations identified as healthy sources of protein in comparison to meat. This alternative offers several social, environmental, and probably health benefits, and it may play a role in reducing meat consumption. However, there has been a lack of research on how specific meat substitute attributes can influence consumers to replace or partially replace meat in their diets. Research has demonstrated that, in many countries, consumers are highly attached to meat. They consider it to be an essential and integral element of their daily diet. For the consumers that are not interested in vegan or vegetarian alternatives to meat, so-called meathybrids could be a low-threshold option for a more sustainable food consumption behaviour. In meathybrids, only a fraction of the meat product (e.g., 20% to 50%) is replaced with plant-based proteins. In this paper, the results of an online survey with 500 German consumers are presented with a focus on preferences and attitudes relating to meathyrids. The results show that more than fifty percent of consumers substitute meat at least occasionally. Thus, approximately half of the respondents reveal an eligible consumption behaviour with respect to sustainability and healthiness to a certain degree. Regarding the determinants of choosing either meathybrid or meat, it becomes evident that the highest effect is exerted by the health perception. The healthier meathybrids are perceived, the higher is the choice probability. Thus, this egoistic motive seems to outperform altruistic motives, like animal welfare or environmental concerns, when it comes to choice for this new product category.
Current discussions about the concept of nutritional sustainability show a high complexity of this topic leading to many different definitions. Regarding communication issues of nutritional sustainability between actors of food chains this complexity should be reduced. One opportunity to tackle these challenges of reducing complexity might be the concept of ingredient branding. Therefore, the aim of this mini-review is the identification of conditions for ingredient branding application as a communication strategy for nutritional sustainability which might overcome challenges in communicating the complexity between the different stakeholders of supply chains. In doing so, the specific case of agrifood chains is discussed based on the selected characteristics of globalization, increasing consumer demands, foods incorporating credence attributes and price. Along the agrifood chain, a sourcing strategy reflecting nutritional and sustainable aspects might lead to an ingredient branding strategy implying a brand policy for a special ingredient within the final product which is an important component but cannot be clearly recognized by the user. A “nutritional sustainability inside” strategy should reflect the multifaceted information along the agrifood chain and should be based on standardized criteria for nutritional sustainability.
Integration of nutritional and sustainable aspects is a complex task tackled by a few scientific concepts. They include multiple dimensions and functions of food systems trying to provide solutions for harmonic co-evolution of humanity and planet Earth. “Nutritional Sustainability” is differentiated from other concepts which combine nutrition and sustainability as it not only sets environmental sustaining capacity as a baseline level for balanced nutrition, but also aims for the search of food system driving nodes. It does not aim for the support of solutions of producing enough or more food for increasing population (sustainable nutrition), neither does it contradict other similar concepts [sustainable nutrition security, nutritional life cycle assessment (LCA)]. However, it calls for more definite estimation of the carrying capacity of the environment on personal, local, and national levels for the development of more efficient solutions of nutrition balanced in the limits of environmental carrying capacity. The review is providing a few examples of advances in nutritional science (personalized nutrition, nutrigenetics), food technology (personalized food processing, food ecodesign), and food complex systems (artificial intelligence and gut microbiome), which have a great potential to progress sustainable food systems with Nutritional Sustainability set as a guiding concept.
Functional foods are still of increasing interest among the scientific community. Based on the extensive literature about functional foods, four main research areas can be identified: functional food innovation (1); the scientific background of the health benefits of functional foods (2); the regulation of functional foods (3); and consumer acceptance of functional foods (4). These research areas are not detached from each other, and each presents a consumer perspective. Although multifaceted studies focus on consumer acceptance of functional foods, literature regarding a structured framework of the determinants of functional food acceptance is limited. The aim of this review is to provide the reader with an overview of the recent literature on consumer attitudes towards functional foods and with an extensive structured framework of the determinants of functional food acceptance and their intertwined relationships. The scientific literature discusses a plethora of determinants of consumer acceptance of functional foods. These determinants can be categorized into consumer and market attributes, which show interwoven relationships with each other. On the one hand, consumer attributes are widely discussed in the literature, while on the other hand structured analyses of the market perspective are inadequately represented. Additionally, the ongoing development of new scientific findings regarding health benefits of different functional ingredients leads to a large amount of new functional food products in the market. Consequently, the research area of functional foods and in particular consumer acceptance of functional food innovation will remain an important research field in the coming years.
Convergence processes are based on the activity of distinct industry sectors showing cross-industry collaborations. The aim of this paper is to analyze cross-industry collaborations between the food and pharmaceutical sectors in the convergence area of functional foods. Selected companies from food (Nestlé/Danone) and pharmaceutical (Martek/Bayer HealthCare) sectors are analyzed using the determinants of motivation and industrial scope. The analysis shows that food companies are more active in cross-industry collaborations than pharmaceutical companies. The latter are more active at the front-end of the value chain focusing on research and development, and delivering their ingredients to food companies that due to their higher expertise in consumer marketing launch the products. While the first cross-industry collaborations were based on an exploration motivation, those that follow focus on exploitation. Acquisitions and licensing agreements are dominant in inside-out and outside-in processes, whereas strategic alliances and joint ventures are based on a coupled process between the food and pharmaceutical sectors.
The aim of this paper is to advance the research on innovation at the pharma-nutrition interface by analysing the three steps of science, technology and market convergence in the area of probiotics using a life cycle perspective. Results from a bibliometric analysis drawing upon 8245 scientific publications, 2082 patents and 1357 news reports focussing on product launch announcements from 1990 up to 2009 indicate that the proposed curve shapes of the life cycles in the theory based framework can be transferred to the case of probiotics. There is a time shift considering the life cycles showing the same activities of the industrial sectors at different moments of time. The food sector dominates the field of probiotics by driving science, technology and market convergence showing earlier activities in scientific publications, patents as well as product launches, while presenting a higher clockspeed between the different life cycle phases. While the food sector dominates product launches for food products containing probiotics, the pharmaceutical sector dominates the product launches of the supplement market. In addition, a clear trend towards industry convergence can be identified by the growing number of cross-industry activities.
The relevance of cross-industry innovation has increased in recent decades with a growing number of inter-industry fields emerging on the borderline between formerly distinct industries. The aim of this paper is to analyse industry convergence in four probiotics innovation value chains based on the following indicators: cross-industry relationships along the innovation value chain as well as knowledge, technological, regulatory and competence convergence. In so doing, the study delivers a framework of indicators for scrutinising industry convergence processes. In order to identify industry convergence, we analyse companies in the converging area of foods and drugs based on products containing the four bacteria strains: Lactobacillus caseii DN 114001, Bifidobacterium lactis Bb12, Lactobacillus acidophilus LA5 and Lactobacillus rhamnosus. Hence, the commercial availability of the strains on the market serves as a selection criterion. Altogether 12 companies stemming from four industrial backgrounds, food and agriculture (5), pharmaceutics (5), chemistry (1) and personal care (1), as well as one research organisation are identified. Cross-industry relationships occur along the innovation value chains of the four strains. Clear signs of knowledge and technological convergence are found as companies are not only publishing and patenting in the usual area of their own industrial field but also in the area of other industrial fields. Companies with different industrial backgrounds show activities in obtaining health claims indicating regulatory convergence. Companies' competence bases seem to converge as companies with different industrial backgrounds are involved in acquisitions, licencing agreements and strategic alliances (competence convergence). We contribute to the existing body of literature by assessing industry convergence from an innovation value chain perspective with a set of indicators reflecting the intensity of industry convergence. This framework of indicators stemming from literature has not yet been used in a combined comprehensive analysis. Furthermore, we tried to show the characteristics of strategic types driving industry convergence in probiotics.
What determines ingredient awareness of consumers? : A study on ten functional food ingredients
(2014)
Given the importance of consumer awareness of functional food ingredients for healthy food choices, the aim of this study is to explore consumers’ ingredient awareness and the determinants which influence the awareness about functional food ingredients.
A sample of 200 German consumers was interviewed via CATI (computer aided telephone interview) during September 2011. The participants have been asked about their specific awareness regarding to ten functional food ingredients. Likewise, determinants like health status and health motivation have been assessed and their influence on the construct “consumers’ ingredient awareness” has been tested by employing structural equation modeling.
The study shows that consumers’ ingredient awareness varies throughout the sample. Overall it can be stated, that 19% of consumer awareness about functional food ingredients is explained through the described model based on the following predictors: age, educational level, health status, health motivation and information strategies. Among these factors, consumers’ health motivation seems to have the highest relevance to explain consumer awareness. But also the determinants information strategies as well as the education show a significant influence on consumers’ ingredient awareness. As health motivation shows the highest impact on consumers’ ingredient awareness this study underlines the importance of prevention propensity for healthy food choices.
KLEE-Rechnung anwendungsorientiert erläutert
Nur wenn die Grundlagen der KLEE-Rechnung umgesetzt werden und ihre Wirkungen bekannt sind, können unternehmerische Entscheidungen fundiert getroffen werden. Dazu möchte dieses Buch beitragen.
Ausgangspunkt der Kosten-, Leistungs-, Erlös- und Ergebnisrechnung im Krankenhaus bildet die Einordnung der KLEE-Rechnung in das Rechnungswesen, bevor begriffliche und funktionale Grundlagen zur KLEE-Rechnung erörtert werden. Daran schließen sich Ausführungen zur Krankenhausbuchführungsverordnung und zum DRG-System an, da diese krankenhausspezifischen Besonderheiten einen wesentlichen Einfluss auf die Gestaltung der KLEE-Rechnung haben.
Im dritten Kapitel wird die Vorgehensweise der KLEE-Rechnung ausführlich behandelt. Ausgehend von der Darstellung, wie Kosten zu systematisieren sind, welche Prinzipien der Kostenerfassung und Regeln der Kostenzuordnung maßgeblich sind, werden die Inhalte der Kostenarten-, Kostenstellen- und Kostenträgerrechnung beschrieben. Zugleich wird dabei die Leistungs- und Erlösseite betrachtet. Die Kostenkontrolle mit der Kostenlenkung und dem Kostenmanagement rundet diesen Abschnitt ab.
Das vierte Kapitel stellt die Systeme der KLEE-Rechnung in den Mittelpunkt. Die Vorgehensweise der Prozesskostenrechnung als vollkostenbasiertes Rechnungssystem und die Deckungsbeitragsrechnung in ihrer unterschiedlichen Ausprägung als Teilkostenrechnungssystem werden beschrieben. Anwendungsorientierte Beispiele in Aufgabenform vertiefen das Verständnis der verschiedenen Rechnungssysteme.
Im anschließenden fünften Kapitel geht es um die Frage, in welcher Höhe die Ambulanzkosten des Krankenhauses auszugliedern sind. Diskutiert werden hier verschiedene Voll- und Teilkostenmethoden. Die modifizierte Vollkostenrechnung wird in ihrer praktischen Anwendung ausführlich mit Beispielrechnungen dargestellt.
Schließlich ist zu fragen, ob wirtschaftliche Überlegungen nur auf Kosten-, Leistungs-, Erlös- und Ergebnisbetrachtungen abstellen sollten oder ob bzw. welche anderen Parameter die Effektivität und Effizienz der Krankenhäuser erhöhen. Wenngleich auch die ökonomischen Ressourcen begrenzt sind und nach einem ökonomischen Prinzip verlangen, gilt es soziale und ethische Grundlagen zu beachten.
USA als Vorbild?
(2013)
Das Gesundheitswesen in den Vereinigten Staaten bekannt für Spitzenforschung und High-end-Medizin. Auch für das Krankenhausmanagement lohnt der Blick über den großen Teich. Unsere Autorin hat im Rahmen eines Forschungsaufenthalts in New York Interviews mit Geschäftsführern und Mitarbeitern an verschiedenen Kliniken geführt. Ergebnis: In puncto Kostenmanagement zeigt sich, dass die Ressourceneffizienz vergleichsweise wenig ausgeprägt ist, die Rahmenbedingungen für eine hohe Prozesseffizienz hingegen vielfach gegeben sind.
Um Managementaufgaben im Krankenhaus zielgerichteter wahrnehmen zu können, bedarf es der Bereitstellung von ziel- und problemrelevanten externen und internen Informationen durch das Controlling. In diesem Werk wird die spiegelbildliche Gestaltung von Management- und Controllingkonzepten in den Vordergrund gestellt. Es wird gezeigt, wie sich die Beziehungsdynamik zwischen Manager und Controller darstellt und welche Voraussetzungen aus betriebswirtschaftlicher, organisatorischer und verhaltensorientierter Sicht für ein integriertes Management- und Controllingkonzept geschaffen werden müssen.
Eine Woche vor Weihnachten 2008 startete die OMT-DVMT-Ausbildung 2008 – 2010 mit einem Kurswochenende und einer Supervision in München. Vor den 8 Studenten lagen 2 Jahre Ausbildung. Die Inhalte und die zu erbringenden Leistungen waren zwar bekannt, aber wie intensiv die Ausbildung sein sollte, zeigte sich erst im Laufe der Zeit. Da alle Teilnehmer im Berufsleben standen und durchaus auch ein Privatleben mit Kindern hatten, war die Fähigkeit zum Spagat zwischen der Weiterbildung und dem Rest des Lebens gefordert.
Langeweile kam nie auf, das Dozententeam lehrte und vertiefte übersichtlich wissenschaftliche und klinische Inhalte. Thomas Schöttker-Königer und Fiona Morrison referierten an mehreren Wochenenden über Evidence-based Medicine (EBM) und Statistik. Den Satz „Traue nur der Statistik, die du selber gefälscht hast”, kann mittlerweile jeder der Studenten gut nachvollziehen, zu viele Beispiele gibt es dazu in veröffentlichten Studien.
Ralf Schesser und Nina Gärtner-Tschacher vermittelten weiterführende und detaillierte Inhalte zum Schmerzmanagement und der Klassifikation von Rückenschmerzen. Abgerundet wurde die Ausbildung durch den ärztlichen Unterricht von Dr. Hans Knorr, einem Medical-Screening-Kurs von Debra Shirley von der University of Sydney und 4 intensiven Supervisionen, die Jan Herman van Minnen, Thomas Horre, Renate Wiesner, Trisha Davies-Knorr, Marc van Liebergen und John Langendoen-Sertel betreuten.
Ende Oktober fand dann die Abschlussprüfung in München statt. Die zu prüfenden Fächer Ärztlicher Unterricht, Verteidigung der Abschlussarbeit, Patientenbehandlung mit anschließender Diskussion und Technikprüfung verlangten den Studenten noch einmal hohe Konzentration und Geduld ab. Alle Prüfungen wurden am selben Tag von 8.00 bis 18.00 Uhr abgehalten. Schlussendlich konnte bei mehreren Gläsern alkoholhaltiger Erfrischungsgetränke ein überaus positives Resümee des mit Höhen und Tiefen gepflasterten Wegs zum OMT-Examen gezogen werden.
Die OMT-Ausbildung macht deutlich, wie wichtig und aktuell die Bedeutung der Verknüpfung von Wissenschaft und Klinik in der täglichen Arbeit ist. Sie sorgt für eine hochwertige Patientenversorgung und fördert die Qualität der Physiotherapie. Es ist zu hoffen, dass noch mehr Physiotherapeuten diesen Weg wählen und sich hochwertig weiterqualifizieren.
Der Beitrag analysiert den Umgang mit der Covid-19-Pandemie innerhalb der Krankenhäuser und leitet davon Handlungsempfehlungen für das Krankenhausmanagement ab. Dabei geht es sowohl um die Organisation und Ausgestaltung der Patienten- und Personalsteuerung (vorgelagerte Notaufnahmen, Aufnahmestationen, Triage, Covid-19-Testung etc.) als auch um die sich durch die Kontaktbeschränkung ergebene Herausforderung im Umgang mit Besuchern und Lieferanten. Des Weiteren wird auch die betriebswirtschaftliche Steuerung in einer – in allen Belangen – ungewohnten Situation beleuchtet.
Mit der Struktur des Krankenhausfinanzierungssystems werden geplante und nicht geplante Anreize für Krankenhäuser gesetzt, Kosten und Erlöse zu steuern. Mit einem Personalkostenanteil von über 60 % an den Gesamtkosten liegt dabei der Schwerpunkt auf den Personalkosten. Eine Folge davon kann eine kosten- und erlösbezogene Personalsteuerung und damit eine qualitative Veränderung der patientenbezogenen Versorgungsprozesse sein. Der Beitrag ordnet die Personalkostenvergütung in die G-DRG-Vergütungssystematik ein. Er beschreibt die Entwicklung des Personaleinsatzes bzw. der Personalkosten seit Einführung des fallbezogenen, preisbasierten Finanzierungssystems, die politischen Reaktionen auf die praktizierte erlösorientierte Personalsteuerung sowie die erwarteten Auswirkungen einer tagesbezogenen, kostenbasierten Pflegevergütung gemäß PpSG auf die Leistungen und Kosten der Versorgungsprozesse sowie auf die Erlössituation der Krankenhäuser. Davon abgeleitet wird der finanzierungssystemabhängige Handlungsbedarf des einzelnen Krankenhauses und es wird dargestellt, welche Rahmenbedingungen das Krankenhausmanagement für eine interne Personalsteuerung systemunabhängig schaffen muss, damit die Qualität der Versorgungsprozesse sichergestellt ist. Die datengestützte Diskussion greift die Erfahrungen in der Praxis mit auf.
Kreditfinanzierungen im Krankenhauswesen werden u. a. aufgrund bestehender Investitionsstaus und aktueller Herausforderungen aus dem Umgang mit der COVID-19-Pandemie weiter an Bedeutung gewinnen. Der folgende Beitrag fasst die Ergebnisse einer Anfang 2019 veröffentlichten Dissertation zusammen: eine Bestandsaufnahme und Analyse der heutigen Finanzkommunikation zwischen Krankenhaus und Kreditinstitut, die bestehende Problemfelder und kritische Faktoren der Finanzkommunikation identifiziert und Handlungsempfehlungen für beide Parteien zur Verbesserung der Finanzkommunikation und zur Begegnung der Herausforderungen zukünftiger Kreditfinanzierungen ableitet.
Insbesondere in wissensintensiven Unternehmen wie dem Krankenhaus birgt die Umstellung auf digitale Prozesse ein großes Innovations- und Produktivitätspotenzial. Der Beitrag erörtert und bewertet die Digitalisierungsfrage aus der betrieblichen Sicht des Krankenhausmanagements hinsichtlich der Voraussetzungen und der aktuell als realistisch einzuschätzenden Potenziale für das Unternehmen. Ausgehend von einer Begriffsklärung der Digitalisierung wird der Zusammenhang zwischen Digitalisierung und Krankenhausorganisation betrachtet. Daran knüpfen Ausführungen zu organisatorischen, personellen und finanziellen Voraussetzungen eines digitalen Krankenhauses an. Bei der Darstellung der Potenziale wird zwischen innerbetrieblichen und unternehmens- bzw. institutionenübergreifenden Aspekten eines digitalen Krankenhauses unterschieden. Ein besonderes Augenmerk wird auf die Elektronische Patientenakte (EPA) gelegt, da sie für den medizinisch-pflegerischen Kernprozess im Krankenhaus besonders wertvoll ist. Am Beispiel der Materialwirtschaft/Logistik werden die digitalen Anwendungsmöglichkeiten in den Unterstützungsprozessen des Krankenhauses erläutert.
Personalsicherung ist eine gesundheitspolitische und
krankenhausmanagementbezogene Aufgabe. Die Verbindung zwischen Politik und Management kann über geeignete externe, politische Rahmenbedingungen und interne, managementbezogene Struktur- und Steuerungsmaßnahmen hergestellt werden. Dabei stellt sich zur Zeit die Frage, inwieweit über Gesetze und Verordnungen Vorgaben zum Personalbedarf gemacht werden sollen. Aktuelle Diskussionen zum Spannungsfeld zwischen politischer Gestaltung und Freiräumen des Managements bis hin zur Frage, inwieweit der Personalbedarf in einem Preissystem adäquat abgebildet werden kann, bilden den Gegenstand dieses Beitrags.
Hintergrund und Ziele:
In der Physio- und Ergotherapie sowie in der Logopädie in Deutschland herrscht bereits seit mehreren Jahren ein Fachkräftemangel. Die Gründe für diesen Mangel sind vielschichtig, in vorhandenen Studien werden jedoch nur einzelne Ursachen genauer beleuchtet. Ziel dieser Arbeit ist es daher auf der einen Seite, die Einflussgrößen auf die Fachkräfteentwicklung zusammenzustellen. Da durch Diskussionen immer wieder die These aufgestellt wird, dass eine Vollakademisierung einen negativen Effekt auf die Fachkräfteentwicklung hat, sollen auf der anderen Seite die Veränderungen der Studierenden-, Absolventen- und Beschäftigtenzahlen in Österreich und der Schweiz vor und nach der Akademisierung untersucht und dargestellt werden.
Methode:
Zur Untersuchung der verschiedenen Gründe für den Fachkräftemangel in den Therapieberufen wurde eine systematische Literaturrecherche im Sinne eines Scoping Reviews durchgeführt. Die Daten zu Studierenden-, Absolventen- und Beschäftigtenzahlen in Österreich und der Schweiz wurden als Sekundärdatenanalyse erhoben und interpretiert.
Ergebnisse:
Die Gründe für den Fachkräftemangel in den Therapieberufen sind viel-schichtig. Als Kategorien wurden der demografische Wandel, die Bedingungen der Ausbildung sowie die Berufsflucht recherchiert. Die Ursachen zum Verlassen des Berufes findet man in finanziellen Aspekten, den Arbeitsbedingungen insgesamt und der fehlenden Anerkennung und Wertschätzung. Die erhobenen Daten aus Österreich und der Schweiz zeigen insgesamt einen positiven Trend in den letzten Jahren. Die Studierenden- und Absolventenzahlen sind in den genannten Ländern stetig gestiegen und führten daher auch zu einer Erhöhung der Beschäftigtenzahlen.
Schlussfolgerung:
Die verschiedenen Gründe für den Fachkräftemangel konzentrieren sich grundsätzlich darauf, dass die Attraktivität der Berufsfelder gesteigert werden muss, um Schulabsolventen für die Berufe zu gewinnen und Beschäftigte im Beruf zu halten. Als Lösungsmöglichkeit wird die Akademisierung gefordert, die zu einer Attraktivitätssteigerung führen könnte. Die Zahlen aus Österreich und der Schweiz zeigen, dass es durch die Akademisierung nicht zu einem Einbruch der Zahlen von Personen in Ausbildung in den untersuchten Berufsgruppen gekommen ist und weiterhin sehr viele junge Menschen an einer akademischen Ausbildung in den Heilmittelberufen interessiert sind.
Aims and Objectives:
Preventive home visits are a low-threshold counselling and support approach. They have been reported to achieve heterogeneous effects. However, preventive home visits have the potential to reduce the risk of becoming dependent on long-term care. The aim of this study is to investigate the effect of preventive home visits as a nursing intervention on health-related quality of life of older people in a longitudinal survey and to develop recommendations for which target groups preventive home visits have the highest benefit. The sample consisted of 75 people, aged between 65 and 85, who were able to understand and speak German, had not yet been eligible for benefits from the long-term care insurance and lived in the municipality under study.
Methodological Design and Justification:
A quantitative longitudinal study in order to investigate the effects of preventive home visits.
Ethical Issues and Approval:
There were no ethical concerns. Accordingly, ethical approval was granted.
Research Methods, Results and Conclusions:
The health-related quality of life was recorded four times between 01/2017 and 08/2020 with the Short-Form- Health- Survey- 12 and analysed using descriptive statistics. Results reveal that the physical health status cannot be easily influenced over a short period of time. The main effect, however, is that preventive home visits have a significant positive effect on the mental health status. The main topics during the home visits were mobility, nutrition and social participation. Increased knowledge and motivation for preventive behaviour extended the autonomy of older people. Accordingly, preventive home visits can support a self-determined life in a familiar environment. The results of the present study show that preventive home visits as a nursing intervention in rural areas are successful. In Germany, preventive home visits have not yet been implemented on a regular basis. In order to do so, a general definition of the concept is needed. Preventive home visits should be officially included in the regular health care services in Germany.
Aufgrund veränderter Rahmenbedingungen und Organisationsstrukturen sind die Mitarbeiter im Krankenhaus zunehmend hohen körperlichen und psychischen Belastungen ausgesetzt. Gesunde Mitarbeiter stellen jedoch eine Grundvoraussetzung für die Leistungserstellung im Krankenhaus dar. Mit der Einführung eines Betrieblichen Gesundheitsmanagements wird das Ziel verfolgt, die Gesundheit der Mitarbeiter zu fördern und zu erhalten. Dies kann jedoch nur gelingen in einer Unternehmenskultur, die das Kulturelement der Gesundheit tief in seinem Wertesystem verankert hat. Der folgende Beitrag liefert Grundlagen zur Unternehmenskultur und erläutert die diesbezüglichen Gestaltungsmöglichkeiten des Krankenhausmanagements.
Krankenhauskultur – eine Frage der Entscheidung : Warum gelebte Werte und Normen entscheidend sind
(2018)
This report summarizes and discusses the development, main achievements and overall progress of The Interprofessional European eHealth Programme in Higher Education (eHealth4all@EU) project. The project evolved through a strong partnership between members of the consortium, grounding its activities on previous initiatives like TIGER and taking them one step further while looking into the digital health competencies required by graduate students working in health and care and providing teaching approaches and other initiatives to extend further a set of core competencies: Health Information Systems Interoperability, Data Security and Privacy and Data Analytics. Although the project activities underwent during the pandemic period, a condition that forced reorganization and adaptation of the workplan, the main initiatives like the identification of significant areas of interest for digital health competencies and related relevant teaching methods that foster active learning paved the way for the construction of learning content structured around a syllabus aimed at distance learning and faceto- face learning moments developed with the intent for reuse and fostering the development of these set of competences in future Health Professionals. To this purpose, we are convinced that grounding steps have been taken with these eHealth4All@EU activities and initiatives.
IO6 is a report of the evaluation of the online courses and Summer School. The project plan of eHealth4all@EU guides the evaluation. The aim of the evaluation is to present the strengths and developing parts of the project. The main evaluation themes are eHealth, inter-professional education, and problem-based learning. For the funder’s perspective, evaluation focusing themes of digital support, lifelong learning, an active citizen, and the future. Evaluation of the project assign around all these themes and will find out students’ and teachers’ feelings of satisfaction, efficiency, and quality of the learning experience.
In September 2022, the interprofessional European Summer School on the topic “Information in Healthcare – From Data to Knowledge” was held at the University of Porto. This Summer School included the topics Interoperability, Data Protection and Security and Data Analytics and consisted of an online preparation phase and an attendance phase in Porto. The didactic concept involved problem-based learning using a case study. A variety of course materials were developed and used to achieve the learning objectives. There are plans to continue the Summer School concept at participating institutions in the future, starting with a Spring School 2023 in Osnabrück.
Interoperability, Data Protection and Security and Data Analytics are of high relevance for the future of eHealth and interprofessional care. Three online courses were therefore designed and delivered for these topics, all of which followed the same structure. A variety of materials were developed and different tools for knowledge transfer, communication and collaboration were used.
Problem-based learning (PBL) has become established as a successful didactic approach far beyond the field of medicine. Although there is no single concept of PBL, there is agreement on its objectives and implementation. Of central importance is the case that supports autonomous and reflective learning. Even before COVID-19, digital methods were used in traditional PBL. These served to support, for example, the provision of learning materials. As a result of university closures during the COVID-19 pandemic, technical solutions were made available at an unprecedented speed, which made it possible to implement the different requirements of traditional PBL in a digital PBL (DPBL). The present study results based on two scoping reviews demonstrated that PBL can be implemented digitally and that different digital methods, both asynchronous and synchronous, are available for the different steps. They show that DPBL not only leads to comparable student performance, but can also develop further competences, e.g. digital communication. With the findings, a concept for the implementation of DPBL as well as recommendations for the further development of DPBL are available.
The University of Eastern Finland was the responsible partner of IO1: European eHealth Education: Policy and Practice Review. The aim of this intellectual output was to customize and validate the already existing international health informatics recom-mendations. Based on that the aim was also to describe the priorities of core compe-tencies and learning outcomes particularly in the fields addressed by this project. The methods used were a scoping review and focus group interviews. The aim of the scoping review was to explore how education in health informatics (HI) has been taught by evaluating the existing international frameworks and reported ed-ucations in HI. The scoping review was conducted based on the instructions of Joanna Briggs Institute to find English language publications published between 2016 and 2020. All publications found in the bibliographical database MEDLINE via PubMed, Scopus and Web of Sciences were included. The results indicated that education in HI is essential to everyone, and everyone needs skills and knowledge in both technical and non-technical skills in HI. Education in HI should be introduced already in the first year of the education and with time increase the knowledge to a more advanced level. The teaching methods can vary between lectures in class to a more hybrid method. The aim of the online focus group interview was to investigate the needs of HI compe-tencies in health care. To achieve the answers, two main questions were used as a base of the interview. The first question focused on how knowledge and competencies in health informatics could contribute to improving health care. The second question focused on which HI competencies are seen as important to learn and how to achieve them. Online focus group interviews were conducted in each of the three countries. The interviews were done the own languages (German, Portuguese, and Finnish) and later summarized and translated to English. The focus group interviews concluded that there are challenges and possibilities in health informatics. It also highlighted the com-petencies seen as important to have in daily working life. For example, skills in appli-cations in patient care, knowledge in IT-background and IT related management are considered important.
Mit Medizinischen Versorgungszentren (MVZ) hat der Gesetzgeber im Jahr 2004 ein kooperatives Versorgungskonzept eingeführt, dass Krankenhäusern den Eintritt in den ambulanten Sektor erleichtert. Betreiben Krankenhäuser ein MVZ, sind sie in der Lage, an der vertragsärztlichen Versorgung der gesetzlichen Krankenversicherung teilzunehmen. Zusätzliche Einnahmequellen lassen sich erschließen. Hinzu treten strategische Überlegungen, die aus Sicht eines Krankenhauses für die Gründung eines MVZ sprechen. Der Beitrag systematisiert mögliche Erlösarten eines MVZ und erläutert deren Bedeutung. Zum Einstieg in die Thematik werden Grundlagen und Strukturmerkmale zum Betrieb eines MVZ beschrieben. Da eine reine Erlösbetrachtung aus betriebswirtschaftlicher Sicht zu kurz greifen würde, wird bei der abschließenden Diskussion die Kostenperspektive thematisiert und hier insbesondere auf die Problematik einer adäquaten Kostenverrechnung eingegangen und auf die Notwendigkeit eines sektorenübergreifenden Controllings hingewiesen. (Hinweis: Aus Gründen der Einfachheit wird in der Regel die männliche Form verwendet; es sind aber stets beide Geschlechter gemeint.)
Der Muster- und Kulturwandel von Krankenhäusern spiegelt sich in Managementansätzen sowie der Organisation und Führung wider. Das Krankenhausmanagement folgt dabei den Rahmenbedingungen der Politik. Fundierte und theoriegeleitete Managementkonzepte - in der Praxis erprobt - können eine Grundlage bilden, um die erforderlichen Rahmenbedingungen für Krankenhäuser zu beschreiben, zu strukturieren, zu argumentieren, von der Politik zu fordern und in der Praxis zu gestalten.
Dieses Werk präzisiert in der 2. Auflage eine Krankenhaus-Managementlehre in Theorie und Praxis. In zahlreichen Beiträgen zeigen Hochschulvertreter und Krankenhausmanager basierend auf dem St. Galler Managementkonzept Ansätze und Aspekte eines integrierten Krankenhausmanagements auf und liefern damit zukunftsorientierte Handlungsempfehlungen für die Krankenhauspraxis und Gesundheitspolitik.
Der Band bestimmt die Ausgangsdaten, um ein Rechnungswesen für Gesundheitseinrichtungen aufbauen zu können, beschreibt und analysiert die Begriffsbestimmungen, Anforderungen und Funktionen eines Rechnungswesens und stellt die gesetzlichen Grundlagen vor. Die Finanzierung von Krankenhäusern und Pflegeeinrichtungen wird herausgearbeitet. Es werden Bilanz, Gewinn- und Verlustrechnung erläutert und darauf aufbauend das interne Rechnungswesen mit seinen theoretischen Grundlagen dargestellt. Zeit- und umfangsbezogene Kostenrechnungssysteme und das Kostenmanagement runden die Ausführungen ab. Die theoretischen Abhandlungen werden praxisrelevant mit Fragen, Aufgaben und Beispiel-Rechnungen hinterlegt.