TY - JOUR U1 - Wissenschaftlicher Artikel A1 - Heinrich, Maria A1 - Nottbrock, Anja A1 - Borchers, Friedrich A1 - Mörgeli, Rudolf A1 - Kruppa-Scheetz, Jochen A1 - Winterer, Georg A1 - Slooter, Arjen J. C. A1 - Spies, Claudia T1 - Preoperative medication use and development of postoperative delirium and cognitive dysfunction JF - Clinical and Translational Science (CTS) N2 - Postoperative delirium (POD) and postoperative (neuro-)cognitive disorder (POCD) are frequent and serious complications after operations. We aim to investigate the association between pre-operative polypharmacy and potentially inappropriate medications and the development of POD/POCD in elderly patients. This investigation is part of the European BioCog project (www.biocog.eu), a prospective multicenter observational study with elderly surgical patients. Patients with a Mini-Mental State Examination score less than or equal to 23 points were excluded. POD was assessed up to 7 days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method (for the intensive care unit [ICU]), and a patient chart review. POCD was assessed 3 months after surgery with a neuropsychological test battery. Pre-operative long-term medication was evaluated in terms of polypharmacy (≥5 agents) and potentially inappropriate medication (defined by the PRISCUS and European list of potentially inappropriate medications [EU(7)-PIM] lists), and associations with POD and POCD were analyzed using logistic regression analysis. Eight hundred thirty-seven participants were included for analysis of POD and 562 participants for POCD. Of these, 165 patients (19.7%) fulfilled the criteria of POD and 60 (10.7%) for POCD. After adjusting for confounders, pre-operative polypharmacy and intake of potentially inappropriate medications could not be shown to be associated with the development of POD nor POCD. We found no associations between pre-operative polypharmacy and potentially inappropriate medications and development of POD and POCD. Future studies should focus on the evaluation of drug interactions to determine whether patients benefit from a pre-operative adjustment. Y1 - 2021 UN - https://nbn-resolving.org/urn:nbn:de:bsz:959-opus-59015 SN - 1752-8062 SS - 1752-8062 SN - 1752-8054 SS - 1752-8054 U6 - https://doi.org/10.1111/cts.13031 DO - https://doi.org/10.1111/cts.13031 VL - 14 IS - 5 SP - 1830 EP - 1840 ER -