TY  - RPRT
U1  - Arbeitspapier
A1  - Berkemeyer, Shoma Barbara
A1  - Lemke, Dorothea
A1  - Hense, Hans Werner
T1  - Incidence and Mortality Trends in German Women with Breast Cancer Using Age, Period and Cohort 1999 to 2008
T2  - PLoS ONE
N2  - Longitudinal analysis investigates period (P), often as years. Additional scales of time are age (A) and birth cohort (C) Aim of our study was to use ecological APC analysis for women breast cancer incidence and mortality in Germany. Nation-wide new cases and deaths were obtained from Robert Koch Institute and female population from federal statistics, 1999–2008. Data was stratified into ten 5-years age-groups starting 20–24 years, ten birth cohorts starting 1939–43, and two calendar periods 1999–2003 and 2004–2008. Annual incidence and mortality were calculated: cases to 100,000 women per year. Data was analyzed using glm and apc packages of R. Breast cancer incidence and mortality increased with age. Secular rise in breast cancer incidence and decline in mortality was observed for period1999-2008. Breast cancer incidence and mortality declined with cohorts; cohorts 1950s showed highest incidence and mortality. Age-cohort best explained incidence and mortality followed by age-period-cohort with overall declining trends. Declining age-cohort mortality could be probable. Declining age-cohort incidence would require future biological explanations or rendered statistical artefact. Cohorts 1949–1958 could be unique in having highest incidence and mortality in recent time or future period associations could emerge relatively stronger to cohort to provide additional explanation of temporal change over cohorts.
KW  - Epidemiology
KW  - Ecological study
KW  - Cancer registry
KW  - Public Health
KW  - Incidnece
KW  - Mortality
KW  - German women
KW  - Breast Cancer
KW  - Age Period Cohort Modelling
Y1  - 2016
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:959-opus-37755
SN  - 1932-6203
SS  - 1932-6203
U6  - https://doi.org/10.1371/journal.pone.0150723
DO  - https://doi.org/10.1371/journal.pone.0150723
SP  - 12
S1  - 12
ER  -